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Active clinical trials for "Diabetic Nephropathies"

Results 181-190 of 427

Dietary Interventions on Glycocalyx Dimensions in South Asian Patients With Diabetic Nephropathy....

Diabetic Nephropathy Type 2Albuminuria8 more

Evaluate the effect of a fasting mimicking diet and a food supplement on the microvascular health and urinary heparanase levels in South Asian type 2 diabetic patients with albuminuria.

Completed20 enrollment criteria

Vascular Endothelial Growth Factor-B (VEGF-B) Blockade With the Monoclonal Antibody CSL346 in Subjects...

Diabetic Kidney Disease (DKD)

This phase 2a, double-blind, randomized, placebo-controlled study will assess the efficacy, safety, tolerability, and pharmacokinetics (PK), of repeat doses of CSL346 in subjects with diabetic kidney disease (DKD) and albuminuria receiving standard of care treatment.

Completed11 enrollment criteria

Gemigliptin and Biomarkers of Kidney Injury and Vascular Calcification

Diabetic Nephropathies

Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control and contain pleiotropic actions on kidney injury, albuminuria and vascular inflammation especially in animal models. We plan to evaluate the efficacy of potent DPP4-inhibitors (gemigliptin) in response to these aspects in diabetic nephropathy patients.

Completed8 enrollment criteria

Effect of Turmeric on Diabetic Nephropathy

Diabetic NephropathyProteinuria

The purpose of this study is to investigate whether turmeric is effective in improvement of diabetic nephropathy and in decrease in the amount of proteinuria and cytokine levels.

Completed4 enrollment criteria

Effect of Pyridorin in Patients With Diabetic Nephropathy

Diabetic Nephropathy

The primary objective of the study is to evaluate the safety and tolerability of Pyridorin (pyridoxamine dihydrochloride) 50 mg given orally twice daily in patients with diabetic kidney disease.

Completed13 enrollment criteria

(ACORD Study) - A Study of NeoRecormon (Epoetin Beta) in Patients With Early Diabetic Nephropathy...

Anemia

This study will assess the effect of anemia correction with NeoRecormon on cardiac structure and function in patients with early diabetic nephropathy. The anticipated time on study treatment is 1-2 years and the target sample size is 100-500 individuals.

Completed9 enrollment criteria

Multiple Dose Trial of Anti-glycation Agent GLY-230 in Healthy and Diabetic Subjects

Diabetic Nephropathy

A dose-ranging study evaluating safety, metabolism and therapeutic dosing of three multiple dose levels of GLY-230 in healthy and diabetic subjects

Completed2 enrollment criteria

Glucose in Dialysis Water in Diabetics With Chronic Renal Failure

Renal FailureChronic1 more

The purposes are 1. to measure the effect of dialysis with glucose in dialysis water on blood pressure, pulse rate, plasma concentration of glucose, plasma concentrations og insulin, glucagon, growth hormone, renin, angiotensin II, endothelin and body temperature, and 2. to analyse the relationship between the changes in blood pressure and changes in vasoactive hormones

Completed10 enrollment criteria

Effect of Enalapril and Losartan Association Therapy on Proteinuria and Inflammatory Biomarkers...

Macroalbuminuric Diabetic Nephropathy

Chronic kidney disease (CKD)has become a significant health problem worldwide. Strategies to decrease the rate of progression of this disease and reduce the number of patients needing dialysis or renal transplantation are urgently needed. In this study we wish to compare the effect of dual blockade of renin-angiotensin system (ACE inhibitors plus angiotensin II receptor blocker) compared to the effect of ACE inhibitor monotherapy in patients with diabetic chronic nephropathy.

Completed10 enrollment criteria

The Effect of Paricalcitol Capsules on Reducing Albuminuria in Patients With Type 2 Diabetic Nephropathy...

Diabetic NephropathyChronic Kidney Disease

The study objective was to evaluate the safety of paricalcitol capsules and the efficacy of paricalcitol capsules for albuminuria reduction in patients with Chronic Kidney Disease (CKD) who have Type 2 diabetic nephropathy and are receiving optimal angiotensin converting enzyme (ACE) inhibitor and/or angiotensin II receptor blocker (ARB) therapy.

Completed28 enrollment criteria
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