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Active clinical trials for "Diabetic Neuropathies"

Results 501-510 of 525

Diffusion Tensor Imaging of Median Nerve in Diabetic Peripheral Neuropathy

Diabetic PolyneuropathyMagnetic Resonance Imaging

This study is a diagnostic accuracy study that aims to evaluate the role of DTI in evaluation of DPN in comparison to clinical scores and nerve conduction studies (NCS). The study included 30 patients with diabetes mellitus complaining of neuropathy symptoms and 15 healthy volunteers. All subjects underwent evaluation using 1.5T DTI of median nerves and NCS. Patients underwent clinical evaluation using Neuropathy Deficit Score (NDS), Neuropathy Impairment Score in the Lower Limbs (NIS-LL) and Diabetic Neuropathy Examination (DNE) score. The values of these tests were compared and correlated and diagnostic accuracy tests were performed together with identification of cut-off score for abnormal diffusion tensor imaging parameters in diabetic neuropathy

Completed2 enrollment criteria

Preclinical Cardiomyopathy and Autonomic Function in Type 1 Diabetes

Diabetes MellitusType 13 more

Type 1 diabetes mellitus is a chronic autoimmune disease, associated with an increased risk of cardiovascular diseases. The development of cardiomyopathy in type 1 diabetes, independent of hypertension and coronary heart disease, is still controversial. A possible mechanism for diabetic cardiomyopathy is autonomic dysfunction. This study aims to evaluate cardiac function and structure, and to relate them with autonomic dysfunction in type 1 diabetes.

Completed8 enrollment criteria

NIR- and Multifrequent Impedance Spectroscopy on the Skin in Type 1 Diabetes

Diabetic Neuropathy

The aim of the study is to examine the suitability to detect diabetic neuropathy using NIR and impedance.

Completed7 enrollment criteria

Nerve Decompression for Ulcer Recurrence Avoidance (DURA)

Diabetic Ulcer of Plantar Aspect of Left FootDiabetic Ulcer of Plantar Aspect of Right Foot1 more

Anecdotal reports and scientific literature suggest that the risk of recurrence of diabetic foot ulcers can be minimized by nerve decompression procedures at anatomic sites of nerve pinching and entrapment. Historical risk of 25% annually has been reported to decrease by >80% to under 5% yearly. Since an open wound precedes the large majority (85%) of amputations in diabetes, avoidance of ulcer recurrences is important. This study tests the current academic opinion that nerve decompression will not decrease ulcer recurrence risk. Null hypothesis: nerve decompression will not decrease diabetic foot ulcer recurrence risk.

Unknown status17 enrollment criteria

Methods of Early Detection and Grading Of Diabetic Peripheral Neuropathy (MEDON)

NeuropathyDiabetic2 more

MEDON aims to examine new methods for early detection and grading of diabetic peripheral neuropathy focusing on both small- and large nerve fibers. Furthermore, MEDON aims to describe differences between people with classic diabetic peripheral neuropathy and those with painful diabetic neuropathy.

Completed9 enrollment criteria

Pain Diabetic Peripheral Neuropathy(DPN) in China

Diabetic Neuropathies

To understand the clinical characteristics of DPN patients in China; To investigate the distribution of DPN patients with depression and anxiety symptoms; To investigate the related factors of moderate and severe pain in DPN patients; To investigate the treatment of pain and depression and/or anxiety in DPN patients.

Completed7 enrollment criteria

Fall Risk Assessment in People With Diabetic Neuropathy

Diabetic Peripheral Neuropathy

Fall risk is increased in people with diabetic peripheral neuropathy (DPN) and yet, minimal research has been conducted to identify appropriate fall risk assessment tools and improve our understanding of falls in these individuals. Purpose: The primary purpose of this study is to establish a foundation of knowledge needed to address falls in people with DPN. This will be accomplished through 1) comparing the validity of 4 fall risk assessment tools, 2) identifying risk factors for falls and 3) determining how quality of life is influenced by factors related to falls in people with DPN.

Completed8 enrollment criteria

Becaplermin Use and Cancer Risk in a Patient Population of U.S. Veterans With Diabetes

Diabetes MellitusFoot Ulcer2 more

The purpose of this study is to evaluate risk of cancer incidence and mortality associated with the use of REGRANEX (becaplermin) in patients with diabetes who are members of a U.S. Veterans Health Administration.

Completed2 enrollment criteria

Complementary and Integrative Therapy for Diabetic Neuropathy

Diabetes MellitusType 21 more

Despite the long tradition of complementary and alternative medicine (CAM) therapies there are hardly any interventional trials on type 2 diabetes mellitus. Hence this pilot study aims to investigate the influence of a two weeks integrative inpatient therapy on the quality of life in 50 patients suffering from diabetic neuropathy. Integrative treatment includes aspects of conventional and traditional European and Chinese medicine, mind-body medicine, physical therapy and lifestyle modification (nutrition advices, stress management and exercise training). The observational design intends four measurement points: tree months before (T0), directly before (T1), directly after treatment (T2) and three months follow-up (T3). The subjective evaluation of the neuropathy-related quality of life was combined with neurophysiologic instruments (QST), to measure neuropathic symptoms. Also pain intensity, locus of control, interpretation of illness, coping style, anxiety/depression, life satisfaction and several biomarkers (HbA1c, ABI, WHR and BMI) are measured. In addition a qualitative interview should give a view to patient perspective of therapy process.

Completed8 enrollment criteria

Understanding Risk Factors and Determinants for Neuropathic Pain

Diabetic Neuropathy

Understanding risk factors and determinants for neuropathic pain.

Completed10 enrollment criteria
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