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Active clinical trials for "Scleroderma, Diffuse"

Results 431-440 of 491

A Systematic Review of Factors Associated With Pulmonary Arterial Hypertension in Systemic Sclerosis...

Pulmonary Arterial HypertensionSystemic Sclerosis

This protocol is of a systematic review for risk factors of pulmonary arterial hypertension in systemic sclerosis.

Completed2 enrollment criteria

Evaluation of Aesthetic Impact in Patients With Systemic Sclerosis

Systemic Sclerosis

The primary objective is to assess the burden of aesthetic complication in systemic sclerosis. Systemic sclerosis is associated with changes in skin aspect which can impact the appearance. Aesthetic burden will be assessed through several scales and compared to a control group of health subjects.

Completed3 enrollment criteria

Is a History of Pre-eclampsia a Risk Factor for Vascular Phenotype in Women With Systemic Sclerosis?...

Systemic SclerosisPreeclampsia1 more

Background: Pre-eclampsia, defined by the association of an arterial hypertension and significant proteinuria after 20 weeks of gestation, complicates 1 to 2% of pregnancies in France. Its pathophysiology involves angiogenesis impairment, upregulated maternal systemic inflammatory response, activation of oxidative stress and endothelial dysfunction. In a recent Danish nation-wide cohort study, pre-eclampsia was associated with a 69% increased risk of later developing scleroderma. Type of study: prospective observational case-control study. Primary objective of the study: to determine if a history of pre-eclampsia before systemic sclerosis diagnosis is an independent risk factor for vascular phenotype in sclerodermic women. Secondary objective: to describe all risk factors for vascular phenotype in sclerodermic women with a previous pregnancy longer than 6 months before scleroderma diagnosis.

Completed17 enrollment criteria

The Impact of Illness Perceptions on Health Related Outcomes in Patients With Lupus and Systemic...

Lupus ErythematosusSystemic2 more

This research project has the overall objective to investigate the direction of the associations between illness perceptions, their influencing factors and health-related outcomes. Moreover, the investigators want to look at the direction of the associations between illness perceptions and health related outcomes such as psychological and physical functioning in patients with Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc). The investigators want to know whether the outcome variables anxiety, depression, physical (dis) functioning are influenced by illness perceptions or vice versa. Not only the patients' illness perceptions but also the illness perceptions of the General Practitioners (GP) and rheumatologists will be investigated. The researchers want to know if the doctors' perceptions have an impact on the physical and psychological functioning of the patient or vice versa. Much research in the field of illness perceptions is cross-sectional in nature which means that the direction of the relationships between variables is not known.

Completed5 enrollment criteria

Digital Ulceration

Systemic SclerosisDigital Ulcers

The CAP study is a multicenter, observational, clinical study in patients with systemic sclerosis. The study aims at determining the usefulness of nailfold videocapillaroscopy and patient-specific disease-related factors in predicting the occurrence of digital ulcers within a 6-month observation period. Patients with cutaneous forms of systemic sclerosis (limited or diffuse), with or without history of digital ulceration are eligible. The study will enroll 500 patients at 70 centers.

Completed10 enrollment criteria

Sleep Disturbances and Pulmonary Artery/Aorta Diameter in Scleroderma Patient

SclerodermaPulmonary Hypertension

To determine sleep disturbance, pulmonary function test, 6 minute walk, echocardiogram abnormality, arterial blood gas, ventilation/perfusion scan of the chest in Scleroderma patient with Pulmonary Hypertension.

Completed2 enrollment criteria

Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 Controls...

Scleroderma

Scleroderma is an autoimmune disease of unknown origin. Recently, the role of environmental factors, and particularly toxic drug exposure, in the genesis of scleroderma has been suggested. This prompted us to conduct this prospective, case-control, multicentric study, including 2 groups of subjects: 100 patients with scleroderma 300 sex- and age-matched healthy controls. The aim of our study is to determine whether exposure to toxics is higher in patients with scleroderma compared with healthy controls.

Completed7 enrollment criteria

Morbidity and Mortality Follow Up for the Scleroderma Lung Study

Scleroderma

The primary intent of this study is to add to the body of knowledge on scleroderma patients with interstitial lung disease. While lung disease is recognized as the leading cause of death amongst patients with scleroderma, there is not a large body of literature describing the long-term morbidity and mortality rate of these scleroderma patients. For this reason, the investigators are following participants of the Scleroderma Lung Study (NCT00004563) after their participation in that study was concluded. In addition, the investigators will assess if the subjects who received one year of oral cyclophosphamide in the Scleroderma Lung Study experienced progression of their scleroderma-related lung disease following the end of the study.

Completed1 enrollment criteria

Scleroderma Lung: Role of Gastroesophageal Reflux, Microaspiration and Cough

Scleroderma Lung

This is a mechanistic research study to evaluate the relationship between cough, reflux, and aspiration in patients with systemic sclerosis (scleroderma).

Completed24 enrollment criteria

Clinical and Paraclinical Characteristics of the Systemic Scleroderma Cohort According to the Criteria...

Systemic Scleroderma

The aim of the study is to compare the exposure to environmental and professional toxics by patients with systemic scleroderma and by patients not achieved by this pathology.

Completed2 enrollment criteria
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