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Active clinical trials for "Dilatation, Pathologic"

Results 81-90 of 238

Gabapentin for Pain Management During Dilation and Evacuation

Pain

Justification. Pain control is still an issue for women undergoing second trimester abortion procedures. The investigators propose a randomized controlled double-blinded trial evaluating the use of adjunct gabapentin versus placebo in addition to moderate sedation during D&E. The investigators hypothesize that 600 mg oral gabapentin administered pre-operatively at the time of cervical preparation initiation will improve intra-operative pain control. The investigators also hypothesize that it will improve pre- and post-operative pain, anxiety, nausea, vomiting, and overall satisfaction with pain management during D&E. To test the hypotheses the investigators plan to enroll 130 participants who will be randomized 1 to 1 to receive either 600 mg gabapentin or placebo at the initiation of cervical preparation.

Completed9 enrollment criteria

Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Control During Cervical Dilator Placement...

Pain Management

This study evaluates the use of Transcutaneous Electrical Nerve Stimulation (TENS) as a method of pain control during osmotic dilator insertion prior to dilation and evacuation. Half the group will have an active TENS unit and half will have a sham or placebo TENS unit.

Completed10 enrollment criteria

A Study to EXhibit Percutaneous Coronary Artery Dilatation With Non-Slip Element Balloon

Coronary StenosisCoronary Artery Stenosis1 more

The objective of this study is to evaluate safety and effectiveness of the Lacrosse NSE ALPHA coronary dilatation catheter during PCI in subjects with stenotic coronary arteries.

Completed45 enrollment criteria

Effect of Chewing Gum on Abdominal Distension in Patients After Lumbar Spine Surgery

Lumbar Spondylosis

According to chewing gum can promote the recovery of gastrointestinal function, it is used as an intervention measure for patients after lumbar surgery to evaluate the effect of chewing gum on improving abdominal distension of patients after lumbar surgery, so as to provide basis for the application and promotion of chewing gum in lumbar postoperative nursing

Completed7 enrollment criteria

Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia

KeratoconusPost-Refractive Ectasia

The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.

Completed16 enrollment criteria

Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia...

Progressive KeratoconusCorneal Ectasia

Prospective, randomized, single site study to determine the safety and effectiveness of performing corneal collagen cross-linking (CCCL)using riboflavin and UVA light in eyes with corneal ectasia or progressive keratoconus.

Completed5 enrollment criteria

Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation

AbortionDilation and Evacuation2 more

Prophylactic tranexamic acid has shown been shown to reduce maternal mortality from postpartum hemorrhage with no adverse effects, but has not been studied to reduce bleeding complications with dilation and evacuation (D&E). We propose a randomized, double-blinded, placebo-controlled pilot study to determine whether routine use of intravenous (IV) tranexamic acid will decrease the need for interventions to control bleeding at the time of D&E at 16 to 24 weeks gestation.

Completed4 enrollment criteria

Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasis...

MydriasisDilation

The objectives of this study are: To evaluate the efficacy of Nyxol (phentolamine mesylate ophthalmic solution 1%) to expedite the reversal of pharmacologic mydriasis To evaluate the safety of Nyxol To evaluate the effect of Lumify® to suppress conjunctival hyperemia (redness) potentially associated with administration of Nyxol

Completed20 enrollment criteria

Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients

KeratoconusCorneal Ectasia

We investigated the use of a copper sulfate eye drop (IVMED-80) for the treatment of keratoconus. Preliminary laboratory data shows that the addition of copper sulfate increase crosslinking of the structural proteins of the cornea thereby halting the progressing corneal thinning and bulging seen in keratoconus. We conducted a Phase 1/2a study to evaluate the safety and preliminary efficacy of a 6-week and a 16-week regimen using IVMED-80 and studied its impact on ocular safety and the change/progression in patients' vision and clinical measurements.

Completed20 enrollment criteria

Drug-eluting PTA Balloon Dilatation Catheter in the Treatment of Peripheral Artery Stenosis or Occlusion...

Peripheral Arterial DiseaseIliac Artery Stenosis5 more

Clinical study on safety and efficacy of ZENFlow™ drug-eluting PTA balloon dilatation catheter in the treatment of iliac, femoral and popliteal artery stenosis or occlusion

Completed5 enrollment criteria
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