Michigan Early Disease Progression Cohort
COPDThe aim of this project is to develop a disease progression cohort within the University of Michigan Health System to capture pulmonary function, symptom assessments and quantitative imaging among patients at risk for or with an established diagnosis of COPD, focusing however on "early" COPD (age 30-55 and GOLD stage 0,1, 2, and prism).
Managing Fear of Cancer Progression Metacognition-based Vs Supportive-expressive Based Approaches...
Advanced or Metastatic CancerFear of Cancer Progression3 moreThe present study aims to conduct a randomized controlled trial to assess the effect of CALM intervention and ConquerFear intervention on fear of cancer progression among Chinese patients diagnosed with advanced cancer.
Genomic Predictors of Papillary Microcarcinoma Disease Progression
Papillary MicrocarcinomaThe study is being done to answer the following question: What are the specific clinical and molecular features that will help us predict which small thyroid cancers are likely to grow and be problematic? Therefore, the purpose of this study is to identify specific clinical and molecular characteristics that are predictive of tumor progression in small thyroid cancers.
To Evaluate the Efficacy of Alirocumab for Neoatherosclerosis by Using OCT, in Comparison With Standard...
Coronary Artery Disease ProgressionThe aim of this study is to evaluate the efficacy of alirocumab for in-stent neoatherosclerosis by using optical coherence tomography, in comparison with standard statin therapy.
Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression...
Parkinson's DiseaseAt present, no drug therapy has been proven to delay the progression of Parkinson's disease (PD). rTMS, as a non-invasive neuromodulation method, can regulate Slow-wave sleep (SWS). SWS is recognized closely related to neurodegeneration. However, there has been no clinical studies on if rTMS could delay the progression of PD by regulating SWS. The main purpose of this study is to explore the changes of SWS in non-rapid eye movement (NREM) sleep period in PD patients by using rTMS, and the relationship with potential improvements of SWS and motor symptom delay. The study aims to find a potential new treatment strategy to delay the neurodegenerative process in PD patients by modulating SWS by rTMS.
ctDNA Analysis to Monitor the Risk of Progression After First-line Immunotherapy in Patients With...
Advanced Lung Non-Small Cell CarcinomaThis study aims to explore the correlation of circulating tumor DNA(ctDNA) and the risk of progression in patients with advanced NSCLC who have long-term benefit from first-line immunotherapy (PFS 12 months)
Social-environmental, Psychosocial, Behavioral, Clinical and Biological Drivers of Disparities in...
Chronic Viral HepatitisHepatitis B InfectionThis study explores how psychosocial factors (e.g., chronic stress, depression) may lead to liver disease progression such as liver cirrhosis or liver cancer among Korean American chronic hepatitis B infection patients. Gathering health information over time from Korean Americans with chronic hepatitis B infection may help doctors find better methods of treatment and on-going care.
Proteomics and Genomics Combined With CT to Predict CVD
Coronary Artery Disease ProgressionThis study evaluates plaque progression and characteristics in patients with coronary atherosclerosis.
Incidence of Bleeding on Probing as an Indicator of Peri-Implant Disease Progression
Peri-ImplantitisBleeding of Subgingival SpaceThe primary goal of the present prospective cohort study is to evaluate the effect of varying incidences of BOP at implant sites across 15 months of maintenance visits on the probability of peri-implant disease progression. Over 15 months, participants will attend 6 visits where clinical measurements and maintenance care will be performed every 3 months.
Neuromelanin MRI: A Progression Marker in Early PD
Parkinson DiseaseProgression1 moreProspective observational study to qualify NM-MRI as progression marker in early Parkinson's.