Efficacy, Safety, and Tolerability of Aclidinium Bromide in the Treatment of Moderate-to-severe...
Chronic Obstructive Pulmonary DiseaseThe purpose of this study is to evaluate the efficacy, safety and tolerability of aclidinium bromide doses compared with placebo in the treatment of moderate to severe, stable chronic obstructive pulmonary disease. The study will be 56 weeks in duration; a 2-week run-in period followed by a 12-week double-blind, placebo-controlled treatment period. This will be followed by an open-label 40-week treatment period and a 2-week follow up phone call. All patients will receive the higher Aclidinium Bromide during the 40-week open label treatment period.
Formoterol-HFA 3-month Study in Chronic Obstructive Pulmonary Disease (COPD) Patients
Chronic Obstructive Pulmonary DiseaseThe purpose of this study is to demonstrate the clinical equivalence of formoterol-HFA pMDI 12µg/actuation administered twice daily to formoterol DPI 12µg/capsule delivered by the Aerolizer inhaler and administered twice daily in patients with COPD.
Long Term Safety and Tolerability of NVA237 Versus Tiotropium in Japanese Patients
Chronic Obstructive Pulmonary DiseaseThis is a 52-week, multi-center, randomized, open label, parallel group study to assess the long term safety and tolerability of once-daily NVA237, using tiotropium as an active control, in Japanese patients with moderate to severe chronic obstructive pulmonary disease (COPD) .
Mindfulness Based Stress Reduction in COPD
Chronic Obstructive Pulmonary DiseaseCOPDThe objective of this study is to test the efficacy of a Mindfulness Based Stress Reduction program in COPD on quality of life, dyspnea, daily physical activity and mindfulness during daily life.
AeriSeal System for Lung Volume Reduction
EmphysemaChronic Obstructive Pulmonary Disease (COPD)2 moreThe purpose of this study is to evaluate the safety and efficacy of AeriSeal treatment in patients with advanced emphysema.
A Phase IIa Study Assessing the Effects of AZD1236 on Biomarkers in Chronic Obstructive Pulmonary...
Chronic Obstructive Pulmonary DiseaseThe primary aim of this study is to investigate the effects of AZD1236 compared with placebo ("inactive substance") in COPD patients by analysing biomarkers for inflammation and tissue degradation in blood, urine and sputum.
High Frequency Chest Wall Oscillation in Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary DiseasePatients with Chronic obstructive pulmonary disease (COPD) tend to have cough, excess mucus production and breathlessness as cardinal features. The excess mucus production often leads to frequent infections, exacerbations and poor quality of life. Mucociliary clearance may have an impact on improving symptoms, exercise tolerance, quality of life and reduce exacerbations. High frequency chest wall oscillation(HFCWO) devices use percussion to the chest wall delivered from a pump through a close fitting inflatable vest. This technique has been shown to enhance mucus clearance in patients with cystic fibrosis and Bronchiectasis. This pilot study was designed to explore the feasibility, tolerance and effectiveness of the HFCWO in patients with advanced COPD.
Does Pulmonary Rehabilitation Improve Balance in People With Respiratory Disease?
Lung DiseasesThe purpose of this study is to determine whether participation in pulmonary rehabilitation improves balance in people with respiratory disease.
Clinical Outcomes of Tiotropium Plus Fluticasone Propionate/Salmeterol Compared With Tiotropium...
Chronic Obstructive Pulmonary DiseaseStudy title A randomized, open label, multicenter, phase 4 study for the comparison of efficacy of tiotropium plus salmeterol/ fluticasone propionate compared with tiotropium alone in COPD patients Study objectives To investigate clinical outcomes of combining tiotropium with fluticasone propionate/salmeterol (FSC) 250/50μg bid compared with tiotropium alone in patients with moderate or severe COPD in Korea Study Design Randomized, open-label, multicenter, parallel-group, two group study Study assessment FEV1 Inspiratory capacity (IC) History of COPD exacerbation History of hospitalization for COPD exacerbation and all causes QoL (SGRQ-C)
Safety and Tolerability of Repeat Dosing of GSK233705/GW642444 in COPD
Pulmonary DiseaseChronic ObstructiveThe purpose of this study is the evaluate the safety and tolerability of repeat dosing of the combination of inhaled GSK233705 and GW642444 administered once-daily in subjects with COPD.