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Active clinical trials for "Lung Diseases"

Results 401-410 of 3242

A Clinical Efficacy and Safety Study of OHB-607 in Preventing Chronic Lung Disease in Extremely...

Bronchopulmonary DysplasiaChronic Lung Disease of Prematurity2 more

The purpose of this study is to determine if an investigational drug can reduce the burden of chronic lung disease in extremely premature infants, as compared to extremely premature infants receiving standard neonatal care alone.

Active11 enrollment criteria

Cardiovascular Risk and Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

The principal objective of the study is to measure parameters of inflammation, oxidative stress, and vascular, respiratory, and peripheral muscle function parameters, and identify parameters indicative of evolving cardiovascular risk (CVR) in COPD patients, using multivariate analysis.

Recruiting24 enrollment criteria

Deployment-Related Lung Disease Research Database and Biorepository

Bronchiolitis

The purpose of this research study is to establish a research database and biorepository for patients at National Jewish Health (NJH) who served in Operation Iraqi Freedom (OIF) or Operation Enduring Freedom (OEF). This study will also include civilian contractors who worked as part of these military operations in Iraq or Afghanistan. The biorepository would store blood samples obtained from these patients during a clinic visit. The research database would store prospectively and retrospectively collected clinical and exposure data that would enable us to comprehensively characterize each case.

Recruiting2 enrollment criteria

Evaluation of the Right Ventricular Systolic Function Using Real-time Three-dimensional Echocardiography...

Ventricular DysfunctionRight2 more

Right ventricular failure (RVF) is an independent factor of mortality for many pulmonary diseases. Currently, RVF is defined as the incapacity of the RV to maintain the flow without dilating to use the Frank-Starling law (i.e., increase of the ejection volume associated to an increase of the preload). RVF is associated to RV systolic dysfunction which is conventionally defined as a decrease of the RV ejection fraction (RVEF) < 45%. In the intensive care unit (ICU), acute RVF is mainly due to the acute respiratory distress syndrome (ARDS), sepsis or septic shock, and less often to severe pulmonary embolism or RV infarction. The anatomical complexity of the RV precludes any geometrical assumption to estimate its volume, hence its ejection fraction (EF) using two-dimensional (2D) echocardiography. For this reason, the evaluation of RV systolic function is currently based on parameters used as surrogates of RVEF: fraction area change in 2D-mode, tricuspid annular plane systolic excursion (TAPSE) in M-mode, and maximal velocity of the systolic S' wave using tissue Doppler imaging. Real-time three-dimensional (3D) echocardiography now enables accurate on-line measurement of RV volume and provides at the bedside the non-invasive assessment of RVEF. 3D transthoracic echocardiography (TTE) has been validated to measure RV volume and RVEF compared to MRI which is the gold standard. However, 3D transesophageal echocardiography (TEE) has not yet been validated in this specific clinical setting, while 2D TEE is frequently used in ICU in ventilated and sedated patients. Accordingly, the diagnostic ability of 3D echocardiography to quantify RV systolic function in ICU patients with RVF of any origin is currently unknown.

Recruiting14 enrollment criteria

Post-marketing Surveillance on Long Term Use of Ofev Capsules in Systemic Scleroderma Associated...

Lung DiseasesInterstitial

The primary objective is to confirm the incidence of adverse drug reactions (focus on gastrointestinal symptoms including diarrhoea and nausea) to Ofev Capsules seen in clinical trials with real world data generated in patients with SSc-ILD.

Recruiting2 enrollment criteria

Pulmonary Hypertension Screening in Patients With Interstitial Lung Disease for Earlier Detection...

Interstitial Lung DiseasePulmonary Hypertension

Study GMS-PH-001 is a multicenter, open-label, non-randomized study to prospectively evaluate screening strategies of pulmonary hypertension (PH) in patients with interstitial lung disease (ILD).

Recruiting18 enrollment criteria

Pulmonary Hypertension Biorepository and Registry

Pulmonary HypertensionPulmonary Arterial Hypertension14 more

Establish a pulmonary hypertension registry and biorepository to lead towards a further understanding of the disease.

Recruiting5 enrollment criteria

Genentech Validation Tool for Pulmonary Fibrosis

Interstitial Lung Disease

Radiology is an important component of the multidisciplinary team. The primary goal of this project will be to create a tool using findings on chest computed tomography (CT) for nearly 300 patients with the most common types of fibrosis. The tool will be tested using chest CT scans of an additional 100 patients with the 3 most common diagnoses of fibrosis. The second objective will be to further validate the tool by performing a reader study with 3 co-investigating radiologists and ask them to look at 100 CT scans of patients with fibrosis without tool and then with tool and see if accuracy of diagnosis improves compared to the working diagnosis when using the tool.

Recruiting2 enrollment criteria

Early COPD for China Pulmonary Health Study Stage II

Obstructive Pulmonary Disease

Discovery of the pathogenesis and targets in the progression of early chronic obstructive pulmonary disease

Recruiting6 enrollment criteria

Glucocorticoids and Pulmonary Hypertension

Pulmonary Hypertension Due to Lung Diseases and HypoxiaPulmonary Hypertension1 more

Pediatric idiopathic pulmonary hypertension has significant morbidity and mortality. An ever expanding body of knowledge indicates the important contribution of inflammation to pathogenesis and successful treatment with glucocorticoids. Over the last several years the investigators have utilized steroids in patients with severe pulmonary hypertension as part of a treatment regimen. These basic science studies possibly identifies a biochemical etiology for the development of disease and may also be impacted by the administration of steroids. Additionally, there is a commercially available assay which tests for all of the above molecules.

Recruiting3 enrollment criteria
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