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Active clinical trials for "Intervertebral Disc Degeneration"

Results 151-160 of 415

BIO4 Clinical Case Study: Cervical Spine

Degenerative Disc DiseaseTrauma (Including Fractures)1 more

The goal of this study is to investigate the efficacy of BIO4 bone matrix in patients undergoing 1 or 2-level Anterior Cervical Discectomy and Fusion (ACDF) spine surgery. Specifically, the study aims to collect the data for ACDF model utilizing BIO4 with Bio AVS Cervical Allograft (with graft window).

Completed27 enrollment criteria

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced Interbody Cages...

Degenerative Disc Disease LumbarSpondylolisthesis1 more

The purpose of this trial is to collect clinical outcomes including radiographic and CT outcomes in patients who undergo interbody spinal fusion using the EVOS Lumbar Interbody System.

Completed20 enrollment criteria

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar...

Degenerative Disc Disease

The purpose of this study is to compare the safety and preliminary efficacy of intradiscal injections of two doses of IDCT (Discogenic Cells + Sodium Hyaluronate vehicle) and one sham control in subjects with chronic low back pain due to Degenerative Disc Disease (DDD) at one lumbar level from L3 to S1.

Completed12 enrollment criteria

Stabilizing Training in Degenerative Disc Disease

Degenerative Disc DiseaseProtrusion2 more

This study evaluates efficacy of stabilizing training of deep core muscles in the lumbar spine in degenerative disc disease subjects, considering the progression level of degenerative disc disease: protrusion or extrusion.

Completed10 enrollment criteria

Study of an Expandable Interbody Device for the Lumbar Spine

Degenerative Disc Disease

The primary objective of this study is to evaluate the safety and efficacy of CALIBER expandable spacer for the treatment of degenerative disc disease. Radiographic outcomes, intra-operative parameters, clinical outcomes, and patient satisfaction will be obtained from patients in this 2 year follow-up clinical study.

Completed9 enrollment criteria

Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral...

Degenerative Disc DiseaseSpinal Stenosis1 more

nanOss Bioactive is approved for use in the U.S. The purpose of this study is to compare fusion results in the posterolateral spine using nanOss Bioactive mixed with autograft bone and bone marrow aspirate (BMA) on one side and autograft alone on the opposite side of the treated level(s). It is hypothesized that the use of nanOss Bioactive will result in fusion at 12 months, with CT evidence of bridging trabecular bone, less than 3mm of translational motion, and less than 5 degrees of angular motion.

Completed29 enrollment criteria

Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies.

Low Back PainLumbago1 more

The treatment of chronic low back pain is a major objective of public healthcare, because it causes an important number of sick leaves. A correlation between clinical observations and an inflammatory discopathy has been underlined, but there is currently any reference treatment. In this study, the main objective is to assess the efficacy of an intradiscal injection of corticoids versus local anaesthetic on the treatment of pain of patients with low back pain associated to a Modic I discopathy.

Completed18 enrollment criteria

A Pilot Study of rhBMP-2/ACS/Allograft Bone Dowel for Anterior Lumbar Interbody Fusion in Patients...

Degenerative Disc Disease

The purpose of this pilot clinical trial is to evaluate the device design as a method of facilitating spinal fusion.

Completed34 enrollment criteria

Pilot Study of rhBMP-2/BCP in Patients With Spinal Degeneration With Instability Requiring Surgical...

Degenerative Disc Disease

This study is designed to generate data relating to patient safety, bone generating activity associated with the use of the rhBMP-2/BCP device as compared to autograft and to evaluate the feasibility of conducting a larger clinical trial in a patient population requiring spinal fusion.

Completed23 enrollment criteria

Intradiscal rhGDF-5 Phase I/II Clinical Trial

Degenerative Disc Disease

Study to show the effectiveness and safety of a single injection of rhGDF5 into a degenerating single spinal disc in treating lumbar level degenerative disc disease

Completed8 enrollment criteria
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