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Active clinical trials for "Drug-Related Side Effects and Adverse Reactions"

Results 1-10 of 374

Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic...

Gestational Trophoblastic TumorEffects of Chemotherapy1 more

In this study, a prospective, multicenter randomized controlled study was conducted to compare the clinical efficacy and toxicity response of combination MTX+ACTD multi-course regimen in low-risk GTN patients with score 5-6 with standard MTX single-drug multi-course regimen.

Recruiting11 enrollment criteria

A Pilot Study to Evaluate Impact on Neurological Side Effects (Cognition, Memory, and Tremor) in...

Kidney Transplant; ComplicationsToxicity2 more

Previous studies have shown that elderly patients experience higher trough levels of tacrolimus and are more sensitive to the effects of medications, they experience higher occurrence and severity of such medication related toxicities. Therefore, the investigators hypothesize that by transitioning patients from tacrolimus immediate release to Envarsus ®, the peak-dose effect will be eliminated or attenuated, leading to a significant decrease in neurocognitive toxicities in the older patient population.

Recruiting16 enrollment criteria

Comparison of Chemoradiotherapy and Chemoradiotherapy Combined With Consolidation Chemotherapy for...

Esophageal Squamous Cell CarcinomaChemotherapy Effect1 more

This study is a phase III, multicenter, prospective randomized controlled clinical study comparing the efficacy of non-surgical esophageal squamous cell carcinoma with radical chemoradiotherapy and radical chemoradiotherapy combined with consolidation chemotherapy. The survival time and side effects of patients were observed and compared.

Recruiting23 enrollment criteria

Ofloxacin Concentration-toxicity Relationship in the Elderly

OfloxacinBone and Joint Infection2 more

Ofloxacin is a gold standard antibiotic for the treatment of bone and joint infections due to sensible staphylococcus strains. However, in the elderly, inter-individual variability of the pharmacokinetics may reduce the efficacy or increase toxicity. The occurrence of ofloxacin side effects is likely to be increased in case of higher exposition. However, the serum concentration-toxicity relationship has not yet been determined. The purpose of this project is to assess the association between the residual serum concentration of ofloxacin at day 3 and the occurrence of at least one adverse effect attributable to ofloxacin, and determine a threshold toxicity concentration if this association exists.

Recruiting6 enrollment criteria

NORTH-REG Dwell-Time Study

Side Effect of Drug

Previous studies show that the majority NMIBC patients experience side effects to BCG and therefore terminate the instillations before completing all planned instillations. This will increase their risk of recurrence and potential cystectomy. The purpose of this study is to investigate if NMIBC patients who experience severe side effects to BCG instillations will experience fewer or less severe side effects if reducing dwell-time of BCG instillations. The study will include patients from Denmark, Iceland, Norway and Sweden.

Recruiting32 enrollment criteria

Safety Assessment for Sotalol Protocol in Outpatient Unit

Supraventricular ArrhythmiaVentricular Arrythmia2 more

Sotalol is an antiarrhythmic medication with proven effects for the suppression and prevention of supraventricular and ventricular arrhythmias. Due to its potential proarrhythmic effect, its introduction should be cautious, and several guidelines recommend starting the medication in hospital settings. However, patients at low risk for a proarrhythmic effect start the medication in outpatient units, despite the lack of clinical studies in the literature that demonstrate the safety of introducing the medication outside the hospital environment. This research project aims to assess the safety introduction of sotalol in an outpatient unit basis. Our hypothesis is that outpatient introduction of sotalol is safe for low-risk patients and an electrocardiographic analysis after 2 hours of the first dose of medication is a predictor of electrocardiographic changes found after 72 hours. In this research, serial electrocardiographic analysis with measurements of the QT corrected intervals and its dispersion, as well as clinical and laboratory parameters will be performed in 110 patients.

Recruiting14 enrollment criteria

The Role of Neuromodulators in Refractory Functional Dyspepsia

DyspepsiaFunctional Gastrointestinal Disorders2 more

The study was designed to investigate the effect of central neuromodulators on refractory functional dyspepsia

Recruiting10 enrollment criteria

Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma

Oncolytic VirusDiffuse Intrinsic Pontine Glioma1 more

This is a single-arm, single-center, drug safety assessment clinical trial with a 3+3 dose escalation design, to observe the safety, tolerability and toxicity of a novel oncolytic virus Ad-TD-nsIL12 intratumoral injection in progressive DIPG patients (NCI-CTCAE V5.0).

Recruiting22 enrollment criteria

Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children:...

Irritable Bowel SyndromeFunctional Abdominal Pain Syndrome4 more

Peppermint oil has shown to be effective in the treatment of Irritable Bowel Syndrome (IBS) symptoms in adults. Few studies of low quality are performed in an paediatric setting. Therefore, the investigators will conduct a multicenter randomized, placebo controlled trial to investigate the effects of an eight-week peppermint oil treatment in paediatric IBS or Functional Abdominal Pain - Not otherwise specified (FAP-NOS) patients.

Recruiting17 enrollment criteria

TIL and Anti-PD1 in Metastatic Melanoma

ToxicityDrug2 more

The ACTME study is an investigator initiated, single center phase I/II clinical trial for patients with progressive unresectable stage III or stage IV melanoma. The trial consists of both a phase I part to determine safety and feasibility and a phase II part to evaluate first clinical activity of IFN-alpha, nivolumab and TIL. The treatment with IFN-alpha will be added after the combination of TIL and nivolumab has proven to be safe.

Recruiting29 enrollment criteria
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