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Active clinical trials for "Dwarfism"

Results 41-50 of 110

Individualizing Dose of Growth Hormone to Maintain Normal Growth Velocity After Fulfilled Catch...

Short Stature

The objective was to study whether normal growth velocity can be maintained with adapted GH dosage in GH treated prepubertal children who have responded to GH treatment with fulfilled catch up growth (=difference to target height reached, less than - 0.6 SDS).

Completed8 enrollment criteria

A Multicentre, Randomised, Open-label, Controlled Study to Evaluate the Effects of Saizen® on Cardiac...

DwarfismGrowth Hormone Deficiency

This was a 48-week, open-label, prospective, multicentric, randomised, comparative with parallel control, Phase 4 study to evaluate the effects of Saizen on cardiac function in GHD subjects during the transition phase from childhood to adulthood. The study was designed to evaluate whether recombinant-human growth hormone (r-hGH) treatment also benefits young subjects with GHD. Some trials have already been published on this subject, but they were mainly focused on the bone density.

Completed22 enrollment criteria

Somatropin (Norditropin) in Insulin-like Growth Factor (IGF) Deficient Children

Growth Hormone DisorderPituitary Dwarfism

This trial is conducted in the United States of America (USA). This is a 12 month study to determine if Norditropin is safe and effective in children with IGF deficiency.

Completed4 enrollment criteria

Recombinant Human Insulin-Like Growth Factor (rhIGF-1) Treatment of Short Stature Associated With...

Insulin-Like Growth Factor-1 DeficiencyGrowth Disorders

This study is intended to assess the effects of once daily dosing of recombinant human insulin-like growth factor (rhIGF-1) in increasing height velocity.

Completed8 enrollment criteria

Height Versus Height and Weight Based Spinal Bupivacaine on Maternal Haemodynamics for Elective...

Maternal Hypotension After Spinal Anesthesia

Doses of intrathecal bupivacaine based on patients either height or height and weight has shown to lower the risk of maternal hypotension with similar quality of anesthesia compared to conventional doses. In clinical practice there is a tendency of reducing the dose of bupivacaine as either low fixed dose or using the doses based on either height and weight or height (0.06mg/cm) alone in parturient with short stature. However, there is lack of evidence regarding the appropriate dose required in this group of patients. Therefore, our aim is to compare the height versus height and weight based intrathecal bupivacaine dose for elective caesarean on maternal haemodynamics in short stature patients.

Completed19 enrollment criteria

Long Term Study of Genotropin (Somatropin) for Short Children Born Small for Gestational Age (SGA)...

Short Stature Born Small for Gestational Age (SGA)

To assess the long-term safety of Genotropin(somatropin) on Small for Gestational Age (SGA) without epiphyseal closing.

Completed8 enrollment criteria

Evaluating the Effect of Nutritional Supplementation on Growth of Short and Lean Adolescents Boys...

Growth ProblemLow Weight1 more

Study design: Double blind, randomized, placebo controlled study. Participants will be randomly assigned either to the intervention group or the placebo control group. Randomization for the two study groups will be made in a ratio of 1:1. The primary objective of the study is to assess the effect of 6-12 months treatment with nutritional supplementation standardized formula, in short and lean boys adolescents on weight Standard Deviation Score (SDS) and height SDS The Secondary Objectives of the study are to assess the effect of 6-12 months treatment with nutritional supplementation standardized formula, in short and lean boys adolescents on BMI SDS, growth velocity, time to puberty, quality of life and self-esteem The study will continue for 6 months of intervention versus active placebo, with additional optional 6 months (an extension period), in which participants at both groups, the intervention and the placebo, will be offered to continue their participation in the study with the study supplement. All analyses of the effect's on primary and secondary outcome measurements will take into account the consumption rate of the study formula/placebo

Completed11 enrollment criteria

Growth Response in Short Children Suffering From a Disease With Growth Retardation and Treated With...

Idiopathic Short Stature

Growth hormone therapy will improve the height of short statured children with pathological conditions that lead to growth retardation. Growth hormone therapy will show an increase in height velocity >1 SD compared to pretreatment height velocity. and the therapy will be safe.

Completed10 enrollment criteria

Growth Hormone and Endothelial Function in Children

Growth Hormone DeficiencyPanhypopituitarism1 more

Objective: This study is designed to determine whether growth hormone treatment in children 8 to 18 years of age alters function of the lining of the arteries. This may play a role in increasing or decreasing the risk of heart disease. Methods. Twenty children, for whom growth hormone therapy will be otherwise provided, will be studied before and 3 months after starting growth hormone. Subjects can be on other hormonal replacements but no other medications. Each study will be done in the fasting state. The blood vessel function will be determined by measuring the change in forearm blood flow before and after blocking flow to the arm for 5 minutes. Blood will be drawn after the test to measure glucose, insulin and fats.

Completed2 enrollment criteria

Effect of Growth Hormone in Children With Growth Hormone Deficiency

Growth Hormone DisorderGrowth Hormone Deficiency in Children2 more

This trial is conducted in the United States of America (USA). The purpose of the trial is to compare the effect of Norditropin® using different dosing regimens in children suspected of growth hormone deficiency.

Completed10 enrollment criteria
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