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Active clinical trials for "Eisenmenger Complex"

Results 11-20 of 21

Combination Treatment With Bosentan and Sildenafil to Patients With Eisenmengers Syndrome

Eisenmenger Syndrome

The purpose of this study is to investigate if combination treatment with Bosentan and Sildenafil to patients with Eisenmenger syndrome is beneficial.

Completed11 enrollment criteria

Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger Physiology...

Pulmonary Arterial Hypertension Related to Eisenmenger Physiology

This study evaluates the effects of bosentan on oxygen saturation, hemodynamics and exercise capacity in patients with pulmonary arterial hypertension related to Eisenmenger physiology. Patients receive bosentan or placebo for 16 weeks.

Completed37 enrollment criteria

BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger...

Pulmonary Arterial Hypertension

This 6-month open label study will evaluate the long term safety of bosentan (via oxygen saturation) and efficacy (exercise capacity) in patients who have completed the BREATHE-5 study (PAH related to Eisenmenger physiology). Treatment duration is 6 months.

Completed13 enrollment criteria

Effects Oxygen Supplementation Determined Better Exercise Capacity in Eisenmenger Syndrome

Eisenmenger ComplexHypertension1 more

The purpose of this study was to evaluate the acute effects of oxygen supplementation during a submaximal exercise test in patients with Eisenmenger's Syndrome.

Completed6 enrollment criteria

The Effects of Inhaled Iloprost on Congenital Heart Disease With Eisenmenger Syndrome

Eisenmenger's Syndrome

Identification of the pathophysiology associated with Eisenmenger's syndrome has led to the evaluation of targeted therapies. Iloprost, a prostacyclin analogue, is one such targeted therapy used in patients with Eisenmenger's syndrome. The purpose of our study is to assess the effects of inhaled iloprost on patients with Eisenmenger's syndrome.

Completed1 enrollment criteria

Eisenmenger's Syndrome in Adults With CHD

Congenital Disorders

Review the outcome of treatment with endothelin receptor antagonists (bosentan or sitaxsetan) alone or in combination with Sildenafil (a PDE-5 inhibitor) in adult patients with pulmonary hypertension due to congenital heart disease.

Completed2 enrollment criteria

Sleep-disordered Breathing in Eisenmenger Syndrome

Eisenmenger SyndromeCongenital Heart Disease1 more

Sleep-disordered breathing (SDB) is a wellknown comorbidity in cardiovascular disease. Knowledge about SDB in adult congenital heart disease is limited.

Completed6 enrollment criteria

Exercise Capacity and Quality of Life in Patients With PPH Receiving Short Term Oral L-Citrulline...

Idiopathic Pulmonary Arterial HypertensionEisenmenger Syndrome

Due to vasodilatory properties of the NO, one of the therapeutic approaches for IPAH is oral use of nitric oxide precursors (10). Efficacy of L-arginine is well-documented in the current literature but there is paucity of data with regard to L-citrulline- malate. Hence, this study will evaluate therapeutic efficacy of L-citrulline- malate in two categories of patients with pulmonary hypertension (IPAH, and Eisenmeger syndrome). This randomized clinical trial utilizes 6-minute walk, pro BNP levels and the echocardiographic indexes an indicator of functional improvement of the patients.

Unknown status14 enrollment criteria

Eisenmenger Quality Enhancement Research Initiative

Pulmonary Arterial Hypertension

Eisenmenger Quality Enhancement Research Initiative (QuERI) is a multi-center, observational, US-based longitudinal program, with enrollment of consecutive Eisenmenger patients who meet enrollment. Patient data will be collected prospectively for three years. Individual physician feedback will be provided on data collected with the purpose of improving the management of patients - quality enhancement research initiative (QuERI) process.

Completed8 enrollment criteria

Six Minutes Walk Test and Shuttle Walk Test in Eisenmenger Syndrome

Eisenmenger ComplexPulmonary Hypertension1 more

The purpose of this study is to verify the applicability Six minutes walk test and Shuttle walk test in assessing functional capacity in patients with Eisenmenger Syndrome. Patients will undergo three functional tests, being the six-minute walk test, shuttle walk test and cardiopulmonary exercise test on a cycle ergometer, associated with evaluation of metabolic and ventilatory variables and cardiac monitoring throughout the test.

Unknown status7 enrollment criteria

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