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Active clinical trials for "Endocrine System Diseases"

Results 71-80 of 258

Saizen® Solution for Injection Adult Growth Hormone Deficiency (GHD) Immunogenicity Study

Growth Hormone Deficiency (GHD)

To assess the immunogenicity of Saizen® solution for injection in adult subjects with documented Growth Hormone Deficiency (GHD).

Terminated19 enrollment criteria

A Long-Term Safety Study of Somavaratan in Japanese Children With Growth Hormone Deficiency

Growth Hormone Deficiency

This study is a multi-center, open-label safety study assessing long-term somavaratan administration.

Terminated19 enrollment criteria

Versartis Trial in Pre-pubertal Japanese Children With Growth Hormone Deficiency (GHD) to Assess...

Pediatric Growth Hormone DeficiencyGrowth Disorders

The trial will consist of three stages: 1) a 30 day Phase 2 PK and PD evaluation of somavaratan, 2) an optional Phase 2 Extension and 3) a 12 month Phase 3 safety and efficacy stage. Upon completion of the PK/PD stage, the PK/PD profiles for the GHD children in this study will be compared to the PK/PD profiles for the GHD children treated in the Western study Phase 1b/2a study (Protocol 12VR2) and identify the somavaratan dose to be used in the Phase 3 stage in Japan. The Phase 3 stage will continue dosing for 12 months to obtain safety and efficacy data on 48 subjects.

Terminated17 enrollment criteria

Efficacy of Somatropin in Adult Patients With Isolated Growth Hormone Deficiency

Growth Hormone Deficiency

The study will investigate the effect on growth hormone replacement in patients with isolated growth hormone deficiency on body composition, especially visceral fat mass.

Terminated4 enrollment criteria

Analysis of Volatile Organic Compounds in Patients With Type 1 Diabetes in Induced Hypoglycaemia...

Diabetes MellitusMetabolic Disease2 more

The breath analysis (BreathSpec® device) data of all participants that were included into the VAARA study (NCT05771090) will be analysed, this includes data from up to 40 breath samples from each of the 10 participants who underwent 2 insulin-induced hypoglycaemic episodes during two visits. The primary objective is to find a possible association between volatile organic compounds (VOCs) measured by the BreathSpec® device and blood glucose. For this we will use descriptive statistics, correlation coefficients, as well as a Principal Component Analysis and a partial least squares discriminant analysis. Furthermore, the time lag between hypoglycaemia onset and change in VOCs will be quantified.

Active16 enrollment criteria

Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19...

COVID 19Coronavirus14 more

The coronavirus disease 2019 (COVID-19) is an emerging pandemic in 2020 caused by a novel coronavirus named SARS-CoV2. Diabetes confers a significant additional risk for COVID-19 patients. Dipeptidyl peptidase 4 (DPP-4) is a transmembrane glycoprotein expressed ubiquitously in many tissues. In addition to its effect on glucose levels, DPP-4 has various effects on the immune system and several diseases, including lung diseases. This trial aims to assess the safety and efficacy of linagliptin, a DPP-4 inhibitor, in the treatment of COVID-19. The trial will be randomized without blinding, with one are treated by insulin only for glucose balance and the other by insulin and linagliptin. The trial will assess the effects of linagliptin on different measures of COVID-19 recovery.

Terminated12 enrollment criteria

Hormonal Contributors to COVID-19 Infection (COV-ENDO)

COVID-19 PandemicEndocrine System Diseases

The goal of this observational study is to measure the changes in the parameters of endocrine function and tissue sensitivity to hormones induced by SARs-CoV-2 infection. The main questions it aims to answer are: Does SARs-CoV-2 infection causes endocrine dysfunctions? Does the treatment of the underlying endocrine dysfunctions, improves the clinical outcome or the occurrence of late onset complications of SARs-CoV-2 infection? Are patients with previously known endocrine diseases more fragile in case of SARs-CoV-2 infection? Participants will undergo blood testing and a physical examination at admission, during hospitalization at discharge and 3 and 6 moths after discharge They results will be compared to those of patients admitted for other reasons in order to assess whether the prevalence of endocrine dysfunctions is increased compared with controls.

Active6 enrollment criteria

Cardiovascular Effects on Growth Hormone Therapy in Adults With Growth Hormone Deficiency

Growth Hormone DisorderAdult Growth Hormone Deficiency

This trial is conducted in Europe. The aim of this trial is to investigate the effect of growth hormone on left ventricle morphology and function (systolic and diastolic).

Terminated4 enrollment criteria

A Study to Evaluate the Efficacy of Somatropin in Adults With Growth Hormone Deficiency Caused by...

Brain InjuriesGrowth Hormone Deficiency Dwarfism

The purpose of this study is to assess the prevalence of GHD in patients who sustain a head injury or suffer a major traumatic event and to evaluate the efficacy of growth hormone (GH) therapy in the treatment of GHD caused by trauma or head injury

Terminated5 enrollment criteria

Treatment Of Adult Growth Hormone Deficiency After Traumatic Brain Injury

Brain InjuriesGrowth Hormone Deficiency

To establish the effects of genotropin replacement on cognitive function in patients with severe growth hormone deficiency after traumatic brain injury.

Terminated7 enrollment criteria
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