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Active clinical trials for "Hyperinsulinism"

Results 81-89 of 89

Towards Individualized Surgery in Non-focal Congenital Hyperinsulinism

Non-focal Congenital Hyperinsulinism

Observational study in patients with non-focal congenital hyperinsulinism showing that restrictive surgery may improve the metabolic situation

Completed2 enrollment criteria

Study of the Use of [18F]-DOPA in Hyperinsulinemic Hypoglycemia

Hyperinsulinemic HypoglycemiaPersistent2 more

The primary objective of this study is to evaluate the utility of [18F]-DOPA PET to provide improved presurgical planning and distinguish between focal and diffuse forms of HI. The investigators will perform descriptive analysis, relying on visual analysis to diagnose and localize a focal lesion. Our findings will be compared to surgical histopathology to determine sensitivity and specificity or this technique. The investigators will also track patient surgical outcomes, specifically whether the patient is surgically "cured" or still requires medical management to control residual hypoglycemia.

No longer available9 enrollment criteria

Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia...

Acanthosis NigricansHyperinsulinemia1 more

Acanthosis Nigricans is skin disease that associated with hyperinsulinemia. Clinical is velvety hyperpigmented plaques on neck, axilla, groin. If hyperinsulinemia is improved by treated with oral metformin and/ or diet control, acanthosis nigricans would be improved as well. Hyperpigmented plaques will be changed. We assess objective measurement by using spectroscopic and colorimetric analysis.

Completed10 enrollment criteria

Genomewide Search for Loci Underlying Metabolic Syndrome

Metabolic Syndrome XCardiovascular Diseases5 more

To identify the genes involved in the metabolic syndrome.

Completed1 enrollment criteria

18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic...

Congenital HyperinsulinismBeckwith-Wiedemann Syndrome1 more

This purpose of this study is to determine the ability of an 18F-fluoro-L-dihydroxyphenylalanine (18F-DOPA) PET scan to detect a focal lesion of hyperinsulinism and determine the location in patients with congenital hyperinsulinism, Beckwith Wiedemann Syndrome and suspected insulinoma. Safety data will be collected.

Available5 enrollment criteria

Whole Body 111In-exendin-4 Imaging Study in Insulinoma Patients

HyperinsulinismHypoglycemia1 more

The purpose of this study is to determine whether the investigators' new imaging modality (111In-exendin-4) has advantages in detecting insulinomas in comparison to conventional imaging.

Completed5 enrollment criteria

GLP-1 Receptor Expression in CHI

Congenital Hyperinsulinism

The primary objective is the in vivo and ex vivo investigation of the expression and distribution of the GLP-1R in the pancreas of CHI patients.

Unknown status11 enrollment criteria

Blood Sugars in Children With Idiopathic Seizures.

SeizuresHypoglycemia1 more

The purpose of this study is to determine if there is a significant percentage of children with the diagnosis of idiopathic seizures who have undiagnosed or unrecognized hypoglycemia (low blood sugar).

Withdrawn9 enrollment criteria

Long Term Glucose Metabolism in Conservatively Treated Patients With Congenital Hyperinsulinism...

Conservatively Treated CHI Patients

The purpose of this study is to continue follow up of conservatively treated CHI patients and to focus on their metabolic outcome, including frequency of hypoglycemia after discontinuing treatment and incidence of diabetes mellitus in the long term.

Unknown status2 enrollment criteria
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