Active clinical trials for "Endometriosis"

Improved pain, sexuality and quality of life, high fertility and low complication and recurrence rates after multidisciplinary CO2 laser laparoscopic excision of deep infiltrating colorectal endometriosis.

At the Leuven University Fertility Centre (LUFC) of the Department of Obstetrics and Gynecology of the University Hospitals Leuven, Belgium, a retrospective epidemiological prevalence study based on an electronic search of patient files was performed to determine the prevalence of histologically proven endometriosis in a subset of infertile women with a regular cycle (variation 21 - 35 days), a partner with normal sperm and no previous surgical diagnosis of endometriosis.

This is a single-center, retrospective case-control study. All consecutive women who underwent classic and nerve-sparing segmental rectosigmoid resection between January 2005 and June 2022 will be included. In the majority of cases classic segmental rectosigmoid resection was done between January 2005 and December 2010. Nerve-sparing segmental rectosigmoid resection has been increasingly employed since January 2011 until now. Preoperative (anamnestic, physical objective, and ultrasonographic data), surgical and postoperative data of the patients included in this study will be analyzed. In particular, postoperative data will be obtained by analyzing reports of follow-up visits, which are routinely done at our institution at 1, 6, 12 months and then every year following the surgical procedures.

This study evaluated the use of ultrasonographic findings as a first-line imaging tool to raise indirect suspicion of parametrial involvement in women suspected of having severe endometriosis (DE).

The purpose of this study is to describe changes in the intensity of specific endometriosis symptoms from baseline pre-surgery to after surgery and subsequent continuous Diphereline (Triptorelin Acetate) treatment for up to 24 weeks.

Comparison between Ovarian reserve markers in patients with minimal/mild endometriosis and patients with tubal factor infertility

Endometriosis is one of the most common benign gynecological, affecting about 10% of premenopausal women. The pathophysiology of this disease is still not completely clear. Despite its prevalence, there is no blood test available for the diagnosis of endometriosis and the average delay time to diagnosis is 9.4 years. Metabolomics is a scientific discipline that studies changes in metabolites related to the pathophysiology of the disease. Aim of the study is to identify an alteration in the expression of the metabolites in women with endometriosis

The aim of this study is to compare the rate of obstetric complications at first spontaneous pregnancy among women with endometriosis, with the rate of obstetric complications at first spontaneous pregnancy among women without endometriosis

Clinical studies so far have been limited, and larger volume and multi-center studies studies are needed. The purpose of this pilot study is to look for a clinical correlations between the aggressivity panel developed from biomarkers thought to affect the progression or aggressivity of endometriosis, pain and quality of life. Our goal with the study is find a correlation between the "aggressivity" of endometriosis with clinical factors determined in our study questionnaires. The "aggressivity panel" was pioneered by the EndoDiag lab in France, and was created using markers thought to affect the activity or progression of endometriosis. This information could lead to a better understanding of the disease, and ultimately lead to more targeted therapies. If a patient returns for a second surgery we will ask their permission to use their slides from their first and seconed surgery to compare. The tissue that is being removed during the surgery as standard of care to make slides for the research study (there will not be an endometrial biopsy performed for research purposes with the second surgery). The slides from surgery 1 & surgery 2 will then be compared. If a clinical correlation is found with the aggressivity panel, the goal would be to create a local lab and tissue bank here in the United States that could provide a basis for collaborative national (even international) research. Also, if a correlation is found, future investigation will look at correlations of the aggressivity panel and fertility outcomes. Results of this pilot study will help to direct studies of treatment protocols of the various stages of aggressivity of endometriosis.

Endometriosis and adenomyosis can impact on the quality of life including the physical, psychological and social aspects. It is important to include quality of life measurements in evaluating the disease severity and response to any given treatment. The 30-item Endometriosis Health Profile (EHP-30), derived from in-depth interviews of patients with endometriosis, is currently the most reliable questionnaire for health-related quality of life measurement in women with endometriosis. It includes specific questions addressing the problems faced by patients with endometriosis. Unfortunately, this widely accepted tool does not have a traditional Chinese version for the measurement of health-related quality of life of endometriosis in Hong Kong. Furthermore, adenomyosis and endometriosis share similar histological and clinical symptomatology, but application of EHP-30 to adenomyosis has never been studied. The aims of the present study are to translate the EHP-30 English version into traditional Chinese version and to evaluate its psychometric properties in endometriosis and adenomyosis. The hypothesis of this study is that EHP-30 (Hong Kong) traditional Chinese questionnaire has high internal consistency, construct validity, reproducibility as the original English version and can be applicable to Hong Kong Chinese women with endometriosis and adenomyosis.