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Active clinical trials for "Drug Resistant Epilepsy"

Results 101-110 of 182

ABI-009 (Nab-rapamycin) for Surgically-Refractory Epilepsy (RaSuRE)

Epilepsy Intractable

This is a prospective, single-center, phase 1 safety study to investigate the safety, tolerability, seizure control, and quality of life in participants with medically-refractory epilepsy who failed epilepsy surgery. These participants will have continued seizures despite being at least 3 months post-epilepsy surgery (resective surgery with an intent to cure).

Completed29 enrollment criteria

The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy

Epilepsy in ChildrenEpilepsy in Youth3 more

The study is investigating if following the low glutamate diet for 1 month, as compared to care as usual, can improve seizure frequency, severity, and duration; cognitive functioning; and/or quality of life in children with epilepsy.

Completed6 enrollment criteria

Safety and Efficacy of 333369 in the Treatment of Partial Epilepsy

Refractory Epilepsy

The primary objective of this study is to evaluate the efficacy, safety, and tolerability of 4 daily doses of RWJ-333369 as adjunctive treatment of refractory partial epilepsy in subjects who are between 18 and 70 years of age, inclusive

Completed9 enrollment criteria

Probiotic in Treatment of Adult Patients With Drug-resistant Epilepsy

EpilepsyTreatment

This study is a randomized, double-blind parallel group placebo-controlled clinical trial with the aim of investigating the effect of probiotic versus placebo on drug-resistant adult patients with epilepsy.

Completed9 enrollment criteria

Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy...

Intractable EpilepsyMalignant Glioma3 more

This phase IV trial studies the side effects and how well perampanel works in reducing seizure frequency in patients with high-grade glioma and focal epilepsy. Perampanel is a drug used to treat seizures. Giving perampanel together with other anti-seizure drugs may work better in reducing seizure frequency in patients with high-grade glioma and focal epilepsy compared to alternate anti-seizure drugs alone.

Terminated19 enrollment criteria

Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures...

Drug-resistant EpilepsyFocal-Onset Seizures

The purpose of the study is to characterize the dose-response relationship with respect to efficacy of Padsevonil administered concomitantly with up to 3 anti-epileptic drugs (AEDs) for treatment of observable focal-onset seizures in subjects with drug-resistant epilepsy.

Completed14 enrollment criteria

Trial Comparing Different Stimulation Paradigms in Patients Treated With Vagus Nerve Stimulation...

Epilepsy

Patients with refractory epilepsy who are candidates for a treatment with vagus nerve stimulation will be prospectively randomized into 3 arms with different vagus nerve stimulation paradigms. Vagus nerve stimulation parameters are programmed and adjusted during outpatient clinic visits, within the normal clinical practice.

Completed10 enrollment criteria

Internet Administration of the Modified Atkins Diet for Adults With Intractable Epilepsy

Epilepsy

This is a prospective, open-label (no control or blind) study to continue to determine whether the modified Atkins diet reduces seizures, creates ketosis, and is well tolerated in adults (not children) with epilepsy. This study will enroll and manage patients via email, phone, and fax and without dietitian involvement (primary difference from previous studies). It is a 3 month study.

Completed16 enrollment criteria

Use of the Atkins Diet for Adults With Intractable Epilepsy

Epilepsy

This is a prospective study to determine whether the Atkins diet reduces seizures, creates ketosis, and is well tolerated in adults with epilepsy. Approximately 30 patients will be enrolled, expecting 20 to complete the 6-month study. The investigators plan to establish the seizure baseline and type, initiate the Atkins diet, then monitor its administration in terms of seizure reduction, ketosis, and side effects for a 6-month period.

Completed12 enrollment criteria

cTBS Targeting Cerebellum for Drug-refractory Epilepsy

Drug Refractory Epilepsy

This study aims to observe the effect and safety of cerebellar continuous θ burst stimulation (cTBS) for drug-refractory epilepsy(DRE), in order to provide a new treatment for DRE and improve the quality of life of those patients. A total of 44 patients with DRE will have cTBS via accurate navigation to bilateral cerebellar dentate nuclei. Patients will be randomised into 2 groups in a crossover trial design to have 2 week periods of cTBS separated by 8 week washout periods, following which the patient will cross over to have the opposite condition for a further 2 week. Frequency and symptoms of seizures, scalp EEG, clinical scores, and QOLIE-31 were assessed at baseline and after 1 and 2 month of treatment.

Completed12 enrollment criteria
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