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Active clinical trials for "Drug Resistant Epilepsy"

Results 171-180 of 182

Expanded Use of Cannabidiol Oral Solution

Refractory Epilepsy

To allow subjects who have completed Insys 030 extension study to continue to take Cannabidiol oral solution.

Available5 enrollment criteria

Added Value of Automated Electrical Source Localization (EPILOG PreOp®) to Presurgical Evaluation...

EpilepsiesPartial

Drug resistant epilepsy is best managed by surgery. The goal of presurgical evalution is to correctly identify the epileptogenic zone, defined by the extent of cortical tissue that needs to be removed is order to achieve seizure freedom. When no causative lesion is identified, careful study of interictal activity is mandatory. Complementary analysis methods exist, designed to identify the source of electrical activity recorded with surface electro-encephalogram. While results are interesting in retrospective studies, the real clinical added value needs to be demonstrated with prospective studies. The company Epilog (Epilog, Ghent, Belgium) offers, with EPILOG PreOp®, a long-term EEG analysis to automatically detect epileptiform activity, combined with an estimation of the electrical source localization using a sLORETA inverse solution model. We will propose the EPILOG PreOp analysis to refractory epileptic patients with non-contributive cerebral imaging, under presurgical evaluation. By comparing the therapeutic decision with and without knowledge of the results of EPILOG PreOp®, we will establish the added clinical value of EPILOG PreOp®.

Unknown status5 enrollment criteria

Treatment of Drug Resistant Epilepsy

Epilepsy

The main goal of this study is to provide treatment with cannabidiol (CBD) to children with drug resistant epilepsy through a Physician Expanded Access Investigation New Drug protocol. As the controlled therapeutic use of CBD in children is novel, the primary objective of this study is to evaluate the safety and efficacy of CBD when administered as adjunctive therapy in children that have exhausted the majority of FDA approved antiepileptic drug treatment options.

No longer available12 enrollment criteria

The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy

EpilepsyUnspecified1 more

Many families of children with medically refractory epilepsy are choosing to use medicinal cannabinoids (MCBD) as an adjunctive alternative treatment option. The safety, tolerability and efficacy of these products are not known. The primary objective of this study is to determine how the use of MCBD affects children with medically refractory epilepsy in an observational study. Measures of evaluation to be used will include: laboratory values, developmental measures, seizure diaries and serial electroencephalographic (EEG) recordings.

Unknown status18 enrollment criteria

Cortical Resections in Drug Resistant Epilepsy

Epilepsy SurgeryDrug Resistant Epilepsy

The aim of the study is to evaluate safety and efficacy of epilepsy surgery in the form of cortical resections in patients with refractory epilepsy and to review outcomes of resection procedures in focal epilepsy.

Unknown status6 enrollment criteria

EXPRESON-IN : Intracerebral Recordings of P3a Responses to Expressive Own-names

Intractable Epilepsy

Neurophysiologic evaluation of disorders of consciousness (DOC) patients in intensive care unit include late auditory evoked potentials. It allows the physicians to record cerebral responses of patients to auditory stimuli and in particularly to their own name (as the P3a response). Numerous studies try to improve the relevance of the auditory stimuli used in this paradigm and notably using more expressive stimuli. Here the investigators investigate the intracerebral correlates of the P3a responses recorded on the scalp with neutral and more expressive stimuli.

Unknown status5 enrollment criteria

Biomarker for Creatine Deficiency Syndromes (BioCDS)

Intellectual DisabilityDevelopmental Delay3 more

Development of a new mass spectrometry-based biomarker for the ear-ly and sensitive diagnosis of the Creatine Deficiency Syndromes from dry-blood-spot sample

Withdrawn15 enrollment criteria

Extended Access Program With Lorcaserin For The Treatment of Dravet Syndrome and Other Refractory...

EpilepsiesMyoclonic1 more

The primary purpose of this study is to provide continued access of lorcaserin to participants with Dravet syndrome and other refractory epilepsies.

Available5 enrollment criteria

Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With...

Refractory EpilepsyFocal Epilepsy1 more

Focal Cortical Dysplasias (FCDs) are neurodevelopmental disorders that represent a major cause of early onset drug-resistant epilepsies with cognitive and behavioral impairments, carrying a lifelong perspective of disability and reduced quality of life. Despite a major medical and socio-economic burden, rationale therapeutic strategies are still under debate. Surgical removal of the epileptogenic brain area (Epileptogenic Zone) is the most successful treatment, yet it fails to control FCD-associated seizures in as much as 40% of cases. Precise definition and complete resection of the Epileptogenic Zone are the main determinants of outcome. In current practice of French centers, up to 80% FCD-patients require an intracranial EEG (icEEG) recording to accurately define the epileptogenic zone. However, the indications for icEEG in MRI-visible FCD remain empirical and are essentially based on expert opinion.

Unknown status15 enrollment criteria

Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Intractable Epilepsy

Refractory Epilepsy

Deep Brain Stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has been proposed in patients with severe intractable epilepsy. When used, the transventricular approach increases the risk of bleeding due the anatomy around the entry point in the thalamus. To avoid such a complication, the investigators used a transventricular microendoscopic technique.

Unknown status5 enrollment criteria
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