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Active clinical trials for "Epilepsy"

Results 1411-1420 of 1503

Brain Network Activation Analysis in Epilepsy

EpilepsyEpilepsy1 more

This is a prospective study investigating the utility of Brain Network Activation (BNA) analysis in patients with epilepsy.

Completed12 enrollment criteria

Epileptogenic Focus Localization for Children With Epilepsy Using 18F-FDG PET Molecular Imaging...

Epilepsy

This retrospective study aimed to develop a new approach for automatic localization of epilepsy foci in children with epilepsy.

Completed5 enrollment criteria

Treatment of Drug Resistant Epilepsy

Epilepsy

The main goal of this study is to provide treatment with cannabidiol (CBD) to children with drug resistant epilepsy through a Physician Expanded Access Investigation New Drug protocol. As the controlled therapeutic use of CBD in children is novel, the primary objective of this study is to evaluate the safety and efficacy of CBD when administered as adjunctive therapy in children that have exhausted the majority of FDA approved antiepileptic drug treatment options.

No longer available12 enrollment criteria

Epidemiologic Follow Up Study of Newly Diagnosed Epilepsy Among Seniors

Epileptic Seizures

The purpose of this proposed research is to identify individuals in southeastern Arizona aged 65 years and older who have new onset seizures (or newly diagnosed epilepsy) and monitor them for at least two years. In doing so the investigators will be able to describe the public health burden of this condition and to identify factors that predict clinical outcomes and health care needs in this population, using quantitative, administrative, and qualitative data. The aims of this proposed research are 1) to determine the two-year incidence of newly diagnosed epilepsy in the target population, 2) describe health care resource utilization of the target population using Medicare data, 3) validate the use of Medicare beneficiary data to estimate incidence of epilepsy, and 4) describe the burden of this condition in different ethnic groups.

Completed4 enrollment criteria

Clinical and Economic Burden of Uncontrolled Epilepsy: Analyses From a Medicaid Database and a Private...

Epilepsy

Antiepileptic drugs (AEDs) are the main therapeutic option for patients with epilepsy; however, complete seizure control remains elusive for many patients. Uncontrolled or refractory epilepsy is associated with a higher risk of mortality, physical injuries, and depression or anxiety compared with patients with controlled epilepsy. Higher resource utilization for patients with poor control is likely to be associated with higher economic costs. While diagnostic criteria for uncontrolled epilepsy are debated by neurologists, recent studies suggest that a diagnosis of uncontrolled epilepsy requires 1.) at least one seizure per month and 2.) a history of drug failures. The objective of this study is to identify patients with uncontrolled epilepsy in both a Medicaid database and a private health plan database, to describe patient characteristics and AED treatment patterns between cohorts of patients with uncontrolled versus well-controlled epilepsy, and to evaluate the economic burden of uncontrolled versus well-controlled epilepsy. For this evaluation, the data sources are medical and pharmacy claims in Medicaid databases from Florida (Third quarter 1997 to second quarter 2008), Iowa (First quarter 1998 to second quarter 2006), Kansas (First quarter 2001 to second quarter 2009), Missouri (First quarter 1997 to second quarter 2008) and New Jersey (First quarter 1997 to fourth quarter 2008) and medical and pharmacy claims in an private health plan database. The study design is a retrospective, longitudinal, matched-cohort study. Eligible patient records will be assigned to one of three mutually-exclusive cohorts: uncontrolled epilepsy (at least 2 consecutive changes in AED therapy in at least 30 days, and at least 1 epilepsy-related inpatient or emergency department (ED) visit within 365 days), well-controlled epilepsy (no AED changes and no epilepsy-related inpatient or ED visits), and intermediate epilepsy (not classified as uncontrolled or well-controlled).

Completed5 enrollment criteria

Determining the Extent of Diffusion Tensor Abnormalities in Focal Cortical Dysplasia

Focal Cortical DysplasiaEpilepsy

Focal cortical dysplasia (FCD) is a common finding in epilepsy surgery in pediatric patients. Children with intractable epilepsy would have extensive tests to identify the cause of epilepsy; this includes MR brain, video EEG and magnetoencephalography (MEG). The white matter next to FCD is frequently found to be abnormal on pathology. Diffusion tensor imaging (DTI) can be used to study the abnormal white matter and the area that often extends beyond the area that is visible.

Completed2 enrollment criteria

The Influence of SISCOM on Intracranial Electrode Implantation in Epilepsy Surgical Candidates

Epilepsy

The aim of this study is to determine the role of SISCOM (see below) in aiding clinicians to manage epilepsy surgery candidates. SISCOM is already a routine component of pre-surgical epilepsy evaluation at Mayo Clinic. In particular, we are interested in assessing whether use of SISCOM can minimize the need for prolonged (>24 hours) invasive monitoring with electrodes placed on the surface of the brain prior to surgical resection. Note: this study has recruited the required number of patients and is closed to further enrolment.

Completed5 enrollment criteria

Why Are Patients With Absence Seizures Absent? A Brain Imaging Study

Childhood Absence Epilepsy

Our study examines which different brain regions are involved in child absence seizures and how they are related to attention and cognition.

Completed4 enrollment criteria

Copeptin in Childhood Epilepsy

EpilepsyFebrile Seizures1 more

In many fields of medicine, except seizure disorders, blood biomarkers have captured an integrated part of diagnostic decision making, including copeptin, the surrogate marker of vasopressin release. There are strong arguments to hypothesize circulating copeptin is elevated in epilepsy, especially in generalized seizures such as fever seizures (FS), and that copeptin is predictive for complexity and relapse at least in FS. Although long-term morbidity and mortality are both low in FS, there is high anxiety among parents because of a lack of criterions to identify children at risk for relapse. Copeptin may fill this gap by adding important diagnostic and prognostic information. Eventually, less children may receive needlessly over years fever drugs or anti-epileptic drugs.

Completed5 enrollment criteria

Detecting Generalized Tonic-Clonic Seizures With a Seizure Detection and Warning System in Epilepsy...

EpilepsyGeneralized Tonic-Clonic Seizures

Prospective study of an electromyography (EMG) based seizure detection and warning system for detecting generalized tonic-clonic (GTC) seizures.

Completed14 enrollment criteria
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