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Active clinical trials for "Epilepsy"

Results 31-40 of 1503

A Clinical Trial of PRAX-562 in Subjects With Developmental and Epileptic Encephalopathies (DEE)...

SCN2A EncephalopathySCN8A Encephalopathy

This is a Phase 2, double-blind, randomized clinical trial to explore the safety, tolerability, efficacy, and pharmacokinetics of PRAX-562 in pediatric participants who have seizures associated with early-onset SCN2A-DEE and SCN8A-DEE.

Recruiting9 enrollment criteria

Epidiolex® for Anxiety in Pediatric Epilepsy

AnxietyEpilepsy

This is a prospective open label study assessing the efficacy and tolerability of pharmaceutical grade cannabidiol--Epidiolex (R), for the treatment of anxiety in pediatric patients with pediatric epilepsy that has been difficult to treat and requires ongoing use of anticonvulsant medication.

Recruiting23 enrollment criteria

Rechargeable Implantable Vagus Nerve Stimulation System for Drug-Refractory Epilepsy

Drug-Refractory Epilepsy

To evaluate the performance of automatic stimulation mode of a new rechargeable implantable vagus nerve stimulation system for drug-refractory epilepsy

Recruiting26 enrollment criteria

Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy

Seizures

Approximately a fourth of children with seizures do not respond adequately to available therapy. Ketogenic therapy has a long history as treatment for intractable epilepsy, but there is no agreement concerning how it works and what is the best way to administer it. This natural history study will collect data pertaining to both questions.

Recruiting5 enrollment criteria

Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)

Epilepsy

The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up.

Recruiting29 enrollment criteria

MR-Guided Focused Ultrasound in the Treatment of Focal Epilepsy (EP001)

Epilepsy

The purpose of this study is to evaluate the feasibility, safety, and initial effectiveness of Exablate thermal ablation of a focal epileptic target area in the brain of patients suffering from medication-refractory epilepsy, using the Exablate transcranial system to produce multiple sonications targeted in the focus of interest. The investigators will establish the feasibility and collect data to establish the basic safety of this type of treatment as the basis for later studies that will evaluate its full clinical efficacy.

Recruiting26 enrollment criteria

Treating Postictal Symptoms Using Ibuprofen and Nifedipine

EpilepsyEpilepsies1 more

This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy. One group will receive ibuprofen, another will receive nifedipine, and anther placebo.

Recruiting2 enrollment criteria

FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy...

Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis

This clinical trial is designed to test whether a single stereotactic intracerebral administration of inhibitory nerve cells into subjects with drug-resistant mesial temporal lobe epilepsy is safe (frequency of adverse events) and effective (seizure frequency).

Recruiting17 enrollment criteria

Role of the Gut Microbiota in Pediatric Epilepsy

Drug Resistant Epilepsy

Nearly a third of children with epilepsy are refractory to pharmacotherapy. The ketogenic diet (KD) is a highly effective alternative therapy reducing seizure frequency by 50% in more than half of treated children. The exact mechanisms of KD remain poorly understood, and recent studies have implicated the gut microbiota (GM). This pilot study aims to determine the feasibility of a 12-week dietary intervention with prebiotic fiber in children with epilepsy. The investigators hypothesize that consumption of inulin will alter gut microbiota and may have effects on seizure frequency.

Recruiting21 enrollment criteria

Hippocampal and Thalamic DBS for Bilateral Temporal Lobe Epilepsy

EpilepsyTemporal Lobe

The study aims to compare the safety and effectiveness of deep brain stimulation of the hippocampus and the anterior nucleus of the thalamus for reducing the frequency of seizures in patients with bilateral temporal lobe epilepsy.

Recruiting13 enrollment criteria
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