search

Active clinical trials for "Dry Eye Syndromes"

Results 701-710 of 976

Autologous Plasma Treatment for Severe Dry Eye Patients

Dry Eye

Patients with severe dry eye who have exhausted conventional treatment are not uncommon and are difficult to manage. They and their physicians are helpless when faced with these scenarios. A small HPRG group, Health Science Authority (HSA) and IRB approved study of autologous plasma eye drop therapy for patients with recalcitrant dry eye has been completed recently by investigators at the Singapore National Eye Centre. The unique feature of the previous protocol was that the autologous plasma preparation was made and contained in sealed segments of intravenous tubing until use by the patient. The study showed that the corneal fluorescein staining of patients who regularly used autologous plasma over a 6 week period improved significantly. Additionally, there was a significant reduction in the total number of topical eye drop treatment required. Investigator did not encounter any cases of infected eye drop preparation or any cases of eye infection. Seventy percent of these patients would recommend this treatment to their relatives and friends suggesting that this form of treatment is a valuable additional modality for dry eyes. Now, investigator would like to extend the short-term pilot study into a long-term single arm clinical trial, in order to determine the best protocol/logistic for this treatment that is practical and still effective, and allowing for more than one plasmapheresis during the study. To achieve this, investigator aim to perform a longitudinal prospective study of patients with severe dry eye who cannot be satisfactorily managed with conventional dry eye treatments using a proposed regime for plasmapheresis and plasma storage.

Withdrawn21 enrollment criteria

Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ...

Dry Eye

Can Lyrica (Pregabalin) help prevent severe Dry Eye post LASIK surgery?

Completed12 enrollment criteria

Dry Eye Syndrome Description During Cataract Surgery, With Multimodal Analysis of the Ocular Surface...

Dry Eye SyndromeOcular Surface Disease

The main objective is to describe the characteristics of dry eye syndrome before and after surgery at one month of cataract surgery, using a multimodal analysis of the ocular surface. The secondary objectives are to evaluate: Predictive factors of dry eye syndrome during cataract surgery: The characteristics of dry eye syndrome Implications for the patient's quality of life

Completed11 enrollment criteria

The Effect of Punctal Plugs on Ocular Surface After Povidone-Iodine Preparation of Intravitreal...

Dry Eye SyndromesDry Eye1 more

The aim of this study is to evaluate the effectiveness of punctal plugs in reducing ocular surface (eye surface) irritation after intravitreal injections prepared by povidone-iodine 5% solution.

Completed11 enrollment criteria

Efficacy and Safety of Meibomian Gland Dysfunction and Dry Eye With an LED Blue Treatment Device...

Meibomian Gland Dysfunction

This study will test the efficacy and safety of application of LED light to meibomian glands in upper and lower eyelids in eyes of patients suffering with meibomian gland disease.

Withdrawn29 enrollment criteria

Repository Corticotropin Injection in Keratoconjunctivitis Sicca

Keratoconjunctivitis Sicca

The purpose of this pilot study is to assess repository corticotropin injection (RCI) in the form of H.P. Acthar Gel in patients with severe keratoconjunctivitis sicca (KCS, or dry eye disease). This pilot study is a non-randomized, open-label, interventional study to assess the efficacy and timeline of RCI for the treatment of severe KCS recalcitrant to conventional therapy. The purpose is to acquire preliminary data to support and guide the design of a future, double-masked, randomized, controlled clinical trial.

Withdrawn15 enrollment criteria

Clinical Efficacy of Intense Pulsed Light(IPL) Procedure in Dry Eye Patient

Dry Eye Syndromes

Clinical efficacy of Intense Pulsed Light(IPL) procedure in dry eye patients with meibomian gland dysfunction prior to cataract surgery.

Withdrawn15 enrollment criteria

Topical Naloxone to Diagnose Ocular Pain

Dry Eye SyndromesNeuropathic Pain

Chronic ocular neuropathic pain may be misdiagnosed as dry eye disease. Our study aims to identify a population with previous monocular trauma and dry eye symptoms and differentiate neuropathic from dry eye pain using topical corneal naloxone hydrochloride.

Completed7 enrollment criteria

Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular...

HealthyDry Eye

The purpose of this study was to determine the safety and retention times of two different lengths (10 mm and 20 mm) of the MINI MONOKA canicular stent when inserted in the eye for up to three months in subjects with or without dry eye.

Completed9 enrollment criteria

Repeatability and Agreement of Anterior Segment Optical Coherence Tomography (AS-OCT) and Thermography...

Dry Eye Syndromes

Dry eye is a common condition that affects vision and quality of life in patients. Dry eye clinical research is limited to follow up of disease progression. Currently, most research outcomes are based on subjective patient complaints rather than objective assessment of the condition. Only few objective measurements for dry eye are available today and this is mainly the result of poor repeatability and inaccuracy. This current study aims to evaluate 2 new non-invasive imaging techniques suitable for dry eye assessment. Anterior segment optical coherence tomography (AS-OCT) is an imaging device that has the ability to image the tear meniscus of the eye in a safe and non-invasive manner. Image analysis can then indirectly determine the tear film volume. Improvements in the image resolution of these devices require a study that compares the repeatability and agreement of an older (Visante AS-OCT) and a newer instrument (Cirrus AS-OCT) which the current study aims to address. Another method of evaluating dry eye disease is a novel technique that uses functional infrared thermography to measure tear evaporation rate. This study will also establish repeatability of measurements of the ocular surface temperature which are used to calculate tear evaporation rates. Should these methods are found to be repeatable, they can be used in future clinical trials as an additional tool to investigate dry eye treatments.

Completed4 enrollment criteria
1...707172...98

Need Help? Contact our team!


We'll reach out to this number within 24 hrs