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Active clinical trials for "Atrial Fibrillation"

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Comparison Between Upgraded '2C3L' vs. PVI Approach for Catheter Ablation of Persistent Atrial Fibrillation...

Persistent Atrial FibrillationCatheter Ablation

Catheter ablation has emerged as an important treatment option for patients with symptomatic atrial fibrillation (AF). Pulmonary vein antral isolation (PVI) is now considered the cornerstone technique of AF ablation and has shown promise in treating paroxysmal atrial fibrillation (PAF). However, there is no unique strategy for ablation of persistent AF (PeAF), whether PVI alone is sufficient to prevent patients from recurrence remains controversial. The PROMPT-AF study is a prospective, multicenter, randomized trial involving a blinded assessment of outcomes, which is designed to compare arrhythmia-free survival between PVI and an ablation strategy termed upgraded '2C3L' for ablation of PeAF.

Recruiting18 enrollment criteria

A New Theory of Electrophysiological Mechanism of Atrial Fibrillation

Atrial Fibrillation

The electrophysiological mechanisms of atrial fibrillation remain disagreements. The goal of this clinical trail is to propose a new electrophysiological mechanism hypothesis of atrial fibrillation(AF),meanwhile, the investigators sought to test the hypothesis that the superposition electrograms (SPEs) recorded during atrial fibrillation could be used as target sites for catheter ablation of atrial fibrillation.

Recruiting13 enrollment criteria

Metformin as an Adjunctive Therapy to Catheter Ablation in Atrial Fibrillation

Atrial Fibrillation

This clinical trial is being done to determine if metformin, a drug which is normally used in diabetes, can reduce atrial fibrillation in patients who are having an ablation for atrial fibrillation (AF). Atrial fibrillation is an abnormal heart rhythm which research has shown is related in part to obesity and diabetes. It is anticipated that the participants treated in the metformin arm will have greater freedom from recurrent atrial arrhythmias after ablation. Eligible participants enrolled in the trial will be assigned to one of the treatment arms (no treatment or metformin) and have follow-up visits up to approximately 1 year after the ablation. Additionally, all patients will also receive education on lifestyle changes and exercise which are standard of care.

Recruiting12 enrollment criteria

Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)

Atrial Fibrillation

Prospective randomized open-label blinded endpoint (PROBE) 2x2 factorial study of metformin extended release up to 750 mg BID and lifestyle and risk factor modification (LRFM) in CIED patients with at least 1 ≥5 minute episode of AF over the prior 3 months. Randomization will be stratified by pacemaker vs. ICD and rhythm at enrollment (sinus rhythm/atrial paced vs. AF).

Recruiting41 enrollment criteria

Low Voltage-Directed Catheter Ablation for Atrial Fibrillation

Atrial Fibrillation - Symptomatic

A two-pronged approach to evaluate long term success of non-paroxysmal ablation when using a: specified low voltage-directed with pulmonary vein isolation (LD+PVI) approach compared to , an approach of pulmonary vein isolation (PVI) alone.

Recruiting31 enrollment criteria

Re-Ablation Using a Tailored Approach Targeting EGM-Dispersion

Atrial Fibrillation

Multi-center, international, non-randomized clinical trial evaluating the use of Volta's VX1 algorithm as used in combination with repeat catheter ablation after AF recurrence after previous catheter ablation.

Recruiting36 enrollment criteria

A Pilot Study to Assess WATCHMAN FLX™ Implants by Cardiac Computed Tomography, Magnetic Resonance...

The Focus of the Study is to Reduce the Risk of Stroke and Life-threatening Bleeding Events in Patients With Non-valvular Atrial Fibrillation

WATCHMAN FLX™ CT is a prospective, single-arm, single-center, post-market investigation to assess device tissue coverage in subjects with non-valvular atrial fibrillation (AF) who receive the WATCHMAN FLX device to reduce the risk of stroke. Serial advanced imaging modalities such as CT and TEE will be used.

Recruiting26 enrollment criteria

Pulmonary Vein (PV) Imaging by Intracardiac Echography (ICE) After Ablation

Atrial Fibrillation Recurrent

To test the hypothesis that structural changes documented by ICE after pulmonary vein deconnection by RF can predict AF recurrences

Recruiting3 enrollment criteria

AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy...

Recurrent Atrial FibrillationPersistent Atrial Fibrillation

A study comparing atrioventricular junction ablation (AVJA) versus continued optimum medical rate control in patients with cardiac resynchronization therapy (CRT) and atrial fibrillation (AF) with suboptimal heart rate control on optimum medication.

Recruiting12 enrollment criteria

Renal Denervation in Patients With Recurrent Atrial Fibrillation After Successful Pulmonary Vein...

Arrhythmia Burden in Patients With RecurrentParoxysmal Atrial Fibrillation Despite Durable Pulmonary Vein Isolation

The aim of this study is to investigate whether renal denervation can reduce arrhythmia burden in patients with recurrent, paroxysmal atrial fibrillation despite durable pulmonary vein isolation.

Recruiting24 enrollment criteria
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