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Active clinical trials for "Hyperlipidemia, Familial Combined"

Results 21-30 of 30

Low Carbohydrate Diet - Effect on Plasma Lipids and Metabolic Markers

Overweight and ObesityType IIb Hyperlipidaemia1 more

Low carbohydrate diet may influence the plasma lipid levels.

Completed2 enrollment criteria

Efficacy and Safety of Fenofibrate Added on to Atorvastatin Compared With Atorvastatin

Mixed Hyperlipidemia

The purpose of this study is to evaluate the efficacy and safety of Atorvastatin and Fenofibrate compared with atorvastatin monotherapy in mixed hypercholesterolemic patients.

Unknown status30 enrollment criteria

Phase 3 Study to Evaluate the Efficacy and Safety of Omega-3-acids Ethylesters 90 in Type Ⅱb Hyperlipidemia...

HyperlipidemiaFamilial Combined

The purpose of this study is to evaluate the efficacy and safety of combination therapy of omega-3-acids ethylesters 90/Atorvastatin calcium in type Ⅱb hyperlipidemia

Unknown status21 enrollment criteria

Comparison of the Efficacy and Safety of AtorVastatin mOnotherapy vs. Combination Atorvastatin/Fenofibric...

Mixed Hyperlipidemia

The purpose of this study is to compare combination atorvastatin/fenofibric acid 10/135mg with atorvastatin 20mg monotherapy in the mixed hyperlipidemia who were not at lipid goals with atorvastatin 10mg monotherapy.

Unknown status18 enrollment criteria

Comparison of High-Dose Rosuvastatin Versus Low Statin Dose Plus Fenofibrate Versus Low Statin Dose...

Dyslipidemia

Statin therapy does not fully eliminate the cardiovascular disease (CVD) risk associated with low high density lipoprotein-C (HDL-C) and high triglyceride levels. It is currently unknown what would be the best treatment option for patients with mixed hyperlipidemia who fail to meet their lipid targets with statin monotherapy at conventional does, i.e. high dose rosuvastatin or conventional statin dose plus micronized fenofibrate or conventional statin dose plus niacin/laropiprant. The aim of the present study is to compare the efficacy of high-dose rosuvastatin vs conventional statin dose plus micronized fenofibrate vs conventional statin dose plus extended-release niacin/laropiprant on lipid profile in patients with mixed hyperlipidemia. The primary efficacy endpoint will be changes in non-HDL-C levels at 6 months after treatment initiation.

Unknown status5 enrollment criteria

Inflammatory Aspects of Glucose in Hyperlipidemia and Diabetes

AtherosclerosisLeukocyte Activation Disorder2 more

In this study, we will investigate both inflammatory systems in healthy volunteers and patients with T2DM on insulin therapy and hyperlipidemia (both familial hyperlipidemia (FH) and familial combined hyperlipidemia (FCH)) during an OGTT.

Completed12 enrollment criteria

Genetic Epidemiology of Hypertriglyceridemia

Cardiovascular DiseasesCoronary Disease3 more

To determine prospectively the role of elevated plasma triglyceride (TG) as a risk factor for 20-year coronary heart disease (CHD) mortality in familial combined hyperlipidemia (FCHL) and familial hypertriglyceridemia (FHTG), the familial forms of hypertriglyceridemia. Also, to perform genetic epidemiologic studies of recently identified lipoprotein risk factors for CHD, including Atherogenic Lipoprotein Phenotypes (ALP) based on subclasses of low-density lipoproteins (LDL), Lipoprotein(a) (Lp(a)) and apolipoprotein (apo) B plasma levels, and apo E isoforms.

Completed1 enrollment criteria

Human Lipoprotein Pathophysiology - Subproject: Genetics of Familial Combined Hyperlipidemia

AtherosclerosisCardiovascular Diseases4 more

To conduct focused studies of lipoprotein physiology and pathophysiology in genetically characterized patients with the objectives of understanding disease mechanisms, developing better treatments, and identifying and preventing early vascular disease.

Completed1 enrollment criteria

Understanding the Genetic Basis of Familial Combined Hyperlipidemia in Mexican Individuals

HyperlipidemiaFamilial Combined1 more

Familial combined hyperlipidemia (FCHL) is an inherited disorder characterized by elevated levels of cholesterol and triglycerides; it often occurs in Mexican individuals with coronary heart disease (CHD). The purpose of this study is to identify the specific genes that predispose Mexican individuals to FCHL.

Completed5 enrollment criteria

Genomic Dissection of a QTL Affecting the Lipid Profile

Cardiovascular DiseasesHeart Diseases3 more

To search for the genetic cause of the metabolic syndrome, a lipid disorder that poses a major risk for coronary heart disease.

Withdrawn1 enrollment criteria

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