Infections and Pregnancy Loss: Correlation Between Abortion and Silent Infections.
Pregnancy LossCorrelation between the presence of intracellular viruses/bacteria and the incidence of miscarriage during the first trimester of pregnancy.
A Feasibility Study of Virtopsy With Tissue Sampling in Besancon University Hospital
Stillbirth and Fetal DeathTermination of Pregnancy1 moreThe aim of this project is to assess the feasibility of a new local post mortem procedure at Besançon University Hospital : Virtopsy+, magnetic resonance (MR) imaging with tissue sampling of the fetus and newborns.
Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task
Post-traumatic Stress DisorderMiscarriage4 moreThis is a randomised controlled trial designed to investigate the impact of a brief-cognitive task based intervention on intrusive memories, mental health symptoms and daily functioning, in women following an early pregnancy loss.
Free DNA and Nucleosome Concentrations in Pathological Pregnancies
PregnancyVenous Thrombosis8 moreThe primary objective of this study is to demonstrate that plasma concentrations of nucleosomes and free DNA differ between three groups: pregnant patients with complications typical of placental insufficiency or venous thrombosis (group P), healthy women (Group T1) and healthy pregnant women (Group T2).
The Use of Cell Free Fetal DNA in the Maternal Blood in the Evaluation of Intrauterine Fetal Demise...
Circulating Cell Free Fetal DNAIntrauterine Fetal Demise1 moreWomen presenting to Washington Hospital Center with fetal loss would be offered participation in the study. The objective is to determine if ccffDNA obtained from maternal blood is present in the setting of missed abortion or fetal demise. The investigators primary hypothesis is that cell free fetal DNA will be present in maternal blood in the presence of a failed pregnancy.
Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss
Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy LossEstablish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance; Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of patients with antiphospholipid antibody-induced pregnancy loss and normal control group; Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of mice with antiphospholipid antibody-induced pregnancy loss and normal control group; After treatment of antiphospholipid antibody-induced mouse abortion model with metformin,the effect of metformin on embryo loss rate and viable embryo body weight was observed.
Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity
Pregnancy ComplicationsPreeclampsia3 moreCongenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine fetal death (IUFD) and repeated pregnancy loss.These severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. Accumulating data have established an association between elevated plasma activity of factor VIII and thrombosis although the mechanism is still not defined and elevated factor VIII activity is now regarded as being equivalent to thrombophilia. We intend to investigatthe association between factor VIII levels and severe pregnancy complications which are considered to result from placental vascular pathology, i.e., preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.
Environmental Factors and Embryonic Development Project
Spontaneous AbortionFetal Death7 moreThe Environmental Factors and Embryonic Development Project was set up to investigate environmental exposures and behavioral factors responsible for embryonic dysplasia and gestational complications in pregnant women.
University Hospital Advanced Age Pregnant Cohort
Advanced Maternal Age PregnancyHigh Risk Pregnancy6 moreThe University Hospital Advanced Age Pregnant (UNIHOPE) Cohort is the major part of the National Key Research and Development Program on Reproductive Health & Major Birth Defects Control and Prevention Project, which is funded by the Ministry of Science and Technology of China. The Project is led by Prof. Zhao Yangyu, from the Department of Gynecology & Obstetrics, Peking University Third Hospital, and the UNIHOPE cohort is led by Prof. Jian-meng Liu, the Co-PI of the Project.
JZ Thickness as a Predictor of Recurrent Unexplained First Trimesteric Pregnancy Loss.
Patients With Recurrent Unexplained Pregnancy LossPatients with history of two or more recurrent pregnancy loss (RPL) and no history of living babies who had performed all investigations for recurrent miscarriage (RM) including : laboratory investigation ,trans vaginal ultrasound (TVS) ,autoimmune work up and hystroscopy and all results were free,will be scheduled for three dimensional trans-vaginal ultrasound (3D TVS) in the midluteal phase for measuring the impedance of uterine artery blood flow( by two dimensional Power Doppler TVS).Also by using 3D power Doppler the sub-endometrial blood flow will be assessed. In addition to the thickness of Junctional Zone (JZ) by using coronal view of 3 D TVS. To be compared with patients who had at least one full term living baby through normal vaginal delivery with no history of early pregnancy loss.