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Active clinical trials for "Mycoses"

Results 491-500 of 546

Optimized Diagnostics for Improved Therapy Stratification in Invasive Fungal Infections

Systemic Mycosis

Invasive fungal infections (IFI) in immunocompromised patients pose a major challenge for diagnostics designed to permit timely onset of appropriate treatment. The aim of the current clinical-diagnostic studies, one in in pediatric and one in adult patients at high risk of IFI, is to test newly developed diagnostic approaches to invasive fungal infections in relation to established procedures. The studies will be performed in a prospective, blinded fashion, and represent a work package within the FUNGITECT grant supported by the European Commission. The studies will focus on analyses of blood-samples from patients with febrile neutropenia during treatment of acute leukaemia and other tumour entities, and patients undergoing allogeneic stem cell transplantation treated with intensive chemotherapy.

Completed11 enrollment criteria

Sautour PHRC IR 2008

Mycosis

Fusarium are microscopic filamentous fungi that live as saprobiontics in outside environments. They are found in the soil, the air, in water and on numerous plants. The frequency of fusariosis is currently increasing and Fusarium-related mycoses are the 3rd most frequent invasive mycoses. Most cases have been reported in the United States, in France, in Italy and in Brazil. A few epidemiological studies have shown the role of water in the appearance of mycoses in highly immunodepressed patients. Few studies have focused on the role of water in the transmission of mycoses in hospitals. The aim of this prospective study is to describe, in time and pace, the contamination by Fusarium sp. in the water of two different hospitals (Dijon, Nancy), by taking into account factors such as seasons and major works (reconstruction of a hospital). In each hospital, one reconstruction site will be compared with a site not under reconstruction (control). Water samples will be taken from the rooms of hospitalized patients.

Completed2 enrollment criteria

Predictive Factors of Mortality in Invasive Fungal Disease in Post-surgical Critical Care Unit

Fungal Invasive Disease

Invasive fungal disease in the critically ill patient is a serious complication that increases hospitalization times, morbidity and mortality, and healthcare costs. Our team proposes a retrospective observational study of patients from the resuscitation unit of the Hospital la Fe who during the years 2016-2019 presented invasive candidiasis. The investigators intend to detect if there are possible specific risk factors that favor the development of invasive candidiasis in colonized patients and if these associated risk factors could be considered as 'triggers' or alerts for the implementation of specific care in these patients. To do this, the investigators intend to study the blood samples taken from patients, taking into account different types of perioperative variables from them, which will be statistically analyzed, so that evidence-based inferences can be drawn to demonstrate our hypothesis.

Completed2 enrollment criteria

Short and Long-term Safety of Micafungin and Other Parenteral Antifungal Agents

Systemic Fungal Infections

This multicenter observational cohort study proposes to establish the risks of short and long-term outcomes in users of parenteral micafungin and in users of other parenteral antifungal agents from 2005 through 2012 with follow-up until 2017.

Completed4 enrollment criteria

Assessment of the Fungal Infection Incidence Across Canada for High Risk Participants With Hematological...

MycosesLeukemia

This will be a retrospective study that includes retrospective chart reviews at major institutions across Canada. The intent of the study is to generate both regional and national incidence data for non-Candida invasive fungal infections (IFI) in high risk participants. The study will include participants receiving stem cell transplant and high dose chemotherapy treatment for leukemia.

Completed4 enrollment criteria

In Vitro Evaluation of Immune Responses in Cutaneous T-Cell Lymphoma (CTCL)

Cutaneous T-cell LymphomaSezary Syndrome1 more

This is an in vitro evaluation of cutaneous T-cell lymphoma using patients' blood and tissue to evaluate immune responses related to identified tumor populations and dendritic/CD 8 cells.

Completed8 enrollment criteria

Evaluation of NGS for Detection and Follow-up of Fungal Pathogens in Immunocompromised Pediatric...

Invasive Fungal DiseaseFever and Neutropenia2 more

The Sponsor hypothesize that Next-generation Sequencing (NGS) can identify fungal pathogens, is more accurate than other noninvasive options and can report fungal genomic load.

Completed3 enrollment criteria

Cell-free Circulating DNA in Primary Cutaneous Lymphomas

Mycosis FungoidesLymphoma2 more

To evaluate the possibility of detecting cell-free circulating tumoral DNA in potentially aggressive primary cutaneous lymphomas, the investigator opted to search a representative tumor sample mutation in the blood of these patients, by digital PCR. Patients with mycosis fungoides, primary cutaneous T-cell lymphoma helper follicular phenotype and primary cutaneous diffuse large B-cell lymphoma, leg-type will be included and 4 blood samples will be collected during 12 months.

Completed6 enrollment criteria

Characterization of Fungal Infections in COVID-19 Infected and Mechanically Ventilated Patients...

Covid-19

Characterization of fungal infections in COVID-19 infected and mechanically ventilated patients in ICU

Completed9 enrollment criteria

Molecular Characterization of Candida Auris

Oral Fungal Infection

Candida auris is emerging fungal opportunistic pathogen in developing countries. Much studies has been conducted on Candida albicans. there was a dire need to investigate this alarming threat. Our hypothesis is that by recording the patients diagnosed with oropharygneal candidiasis and collecting clinical swab samples from these patients will be fruitful if microbiological isolation, identification and molecular characterization will be done. So this is the first study on C. auris in south punjab, Pakistan. Aim of this study is to collect epidemiological data of C. auris.

Completed2 enrollment criteria
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