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Active clinical trials for "Gastroesophageal Reflux"

Results 451-460 of 878

Rabeprazole in Subjects With Gastroesophageal Reflux Disease (GERD)

Esophageal Reflux

The purpose of this study is to determine the production of mucin in GERD/RE subjects before and after 8 weeks of treatment with rabeprazole.

Completed0 enrollment criteria

Compound Sodium Alginate Oral Suspension Sachet 4-hour Esophageal pH Study in GERD Patients

Gastro-esophageal Reflux Disease (GERD)

Multi-centre, randomised, open-label, placebo-controlled, two-period crossover study of 4 hour pH monitoring following a refluxogenic meal and drink.

Terminated31 enrollment criteria

48 Hours Esophagal pH-monitoring With and Without Gaviscon

Gastroesophageal Reflux

At a esophagal pH-monitoring will the classic 24-hour measurement be extended to 48 hours. During the first 24 hours are the measurements without medication. After 24 hours the treatment will be started with Gaviscon and will the next 24 hours the measurements under the medication happen. Normally is the medication required after the measurements. With this study the investigators will have multiple measurement points to compare.

Completed5 enrollment criteria

Contrast Enhanced Ultrasound for Evaluation of Reflux Nephropathy

Urinary Tract InfectionVesicoureteral Reflux

The study will be evaluating the efficacy and safety of a contrast drug in pediatric renal ultrasound.

Completed17 enrollment criteria

Extraesophageal Reflux - Feasibility of Measurement of Pepsin in Saliva as a Diagnostic Option

Extraesophageal Reflux

The diagnostics of extraesophageal reflux (EER) is challenging. Currently, 24-h dual-probe esophageal pH monitoring or impedance is considered the best diagnostic method for EER. The 24-h oropharyngeal pH monitoring is a newer method aimed at detecting episodes of reflux to the oropharynx. Unfortunately, all these methods have many disadvantages. Pepsin detection in saliva would be an almost ideal diagnostic technique. However, data of its reliability is lacking. The aim of the study is to compare results of oropharyngeal pH monitoring and esophageal impedance monitoring, compared to a quantified pepsin presence in the saliva obtained immediately prior to 24-hour monitoring and to evaluate the feasibility of this technique as a routine option of diagnosing the presence of extraesophageal reflux.

Completed5 enrollment criteria

Efficacy of Reza Band for the Treatment of Laryngopharyngeal Reflux

Laryngopharyngeal Reflux

We hypothesize that tissue and salivary pepsin will resolve after 12 weeks use of Reza Band, but not following standard of care alone. Additionally, RFS, RSI and inflammatory cytokines (IL -1β, -6, and -8) will decrease to normative levels following 12 weeks use of Reza Band, but not with standard of care alone. Primary Objective The primary objective is to evaluate the efficacy of the Reza Band for the treatment of LPR. We propose a pilot clinical trial to test the hypothesis that the Reza Band is effective for the treatment of LPR, measured by resolution of pepsin and decrease to normative values for RSI, Reflux Finding Score (RFS) and inflammatory cytokines. The long-term goal is to determine the efficacy of the Reza Band in the sequential progression of reflux-attributed laryngeal inflammatory and neoplastic disease.

Withdrawn17 enrollment criteria

Minimally Invasive Evaluation of Dyspepsia by Combined Magnetically Controlled Capsule Endoscopy...

DyspepsiaPeptic Ulcer Disease3 more

The combined diagnostic accuracy of MCCE and UBT in Hong Kong patients with uninvestigated dyspepsia between age 35 to 60 years for structural pathology and HP infection is comparable to that of conventional UGI endoscopy with histological examination for HP

Completed10 enrollment criteria

Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD

Gastroesophageal Reflux Disease

To the best of our knowledge, there has been no randomized controlled trial to compare double dose PPI therapy with standard one dose PPI therapy for NERD patients. Thus, we hypothesize that a double dose PPI would accelerate and sustain the control of symptom in NERD patients.

Withdrawn12 enrollment criteria

Study Comparing Esomeprazole Associated With Sodium Bicarbonate From Eurofarma and Esomeprazole...

Gastroesophageal Reflux Disease

A phase III, randomized, open-label, superiority study comparing the incremental product esomeprazole associated with sodium bicarbonate made by Eurofarma and Nexium® in the treatment of gastroesophageal reflux disease. The study will enroll 94 patients in each arm (total of 188 patients).

Withdrawn22 enrollment criteria

Predictors of Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis

Gastroesophageal Reflux DiseaseEosinophilic Esophagitis1 more

The investigators will determine the prevalence of gastroesophageal reflux disease (GERD) in Eosinophilic Esophagitis (EoE) and importantly determine the predictors of response to Proton Pump Inhibitor (PPI) therapy in EoE. Moreover, the investigators will determine the effect of GERD on the location of esophageal eosinophilia.

Withdrawn9 enrollment criteria
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