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Active clinical trials for "Gastrointestinal Diseases"

Results 261-270 of 525

Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent...

Bowel DysfunctionConstipation

Adults who are taking opioid therapy for persistent non-cancer pain and have resulting opioid-induced bowel dysfunction (OBD) will be randomized (1:1) to alvimopan or placebo. The primary objective of this Phase 3 long-term safety study is to compare alvimopan with placebo for safety and tolerability in the treatment of OBD. Participants will be required to attend 8 clinic visits over approximately 1 year.

Completed12 enrollment criteria

Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia...

DyspepsiaGastrointestinal Diseases

The purpose of this study was to determine which treatment strategy, the step-up or the step-down treatment strategy, is the most cost-effective treatment for patients with new onset dyspepsia in primary care.

Completed10 enrollment criteria

Cognitive Behavior Therapy (CBT) for Children With Functional Gastrointestinal Disorders

Functional Gastrointestinal Disorders (FGID)FGID According to the Rome III Criteria3 more

The purpose of the trial is to develop a treatment protocol to be used in trials studying internet-delivered CBT for children with functional gastrointestinal disorders (FGID). The study size is not based on power calculations but the estimated sample necessary to develop a treatment protocol. This study will include 20-30 children with FGID and their parents who will be treated individually (face-to-face). The treatment consists of 10 weekly sessions of exposure-based CBT. The study uses a pre- post-design with no control group.

Completed8 enrollment criteria

Evaluation of the Safe Use and Tolerance of a Peptide-based Formula in a Pediatric Population

Gastrointestinal DiseasesFeeding Intolerance

The objective of this study is to determine the safe use and tolerance of a peptide-based formula in children with gastrointestinal dysfunction and/or feeding intolerance.

Completed9 enrollment criteria

The Treatment of Acute Gastrointestinal Injury Via Ultrasound-guided Erector Spinae Plane Block...

Gastrointestinal Disease

In this single-center, randomized, parallel control clinical trial, patients will be randomly assigned to two groups. The treatment group receives ultrasound-guided erector spinae plane block with routine treatment of Acute Gastrointestinal Injury (AGI) for 7 days or until transferred to the general ward, while the control group only receives routine treatment of AGI. The primary outcome is the cure and remission rate of AGI.

Completed16 enrollment criteria

A Randomized, Double-Blind, Placebo Controlled Trial Evaluating the Impact of Nystatin on the Development...

CandidiasisOral2 more

In patients who are receiving intravenous high dose Interleukin-2, patients will be randomized into two groups: group one will receive nystatin swish and swallow immediately before initiation of IL-2, and the second group will receive a placebo. The patients in each group will be monitored and evaluated for differences in the rate and severity of development of oral irritation during treatment. They will also be studied for differences between the two groups in the number of doses of IL-2 taken.

Completed7 enrollment criteria

Phase III Multicenter, Open-Label, Randomized Trial of Induction Versus Induction Plus Maintenance...

HIV InfectionsGastrointestinal Diseases

PRIMARY: To compare the frequency of and time to relapse of Cytomegalovirus (CMV) gastrointestinal disease following foscarnet induction therapy only versus induction plus maintenance therapy. SECONDARY: To determine frequency of and time to recurrence of gastrointestinal symptoms, response rate of pathological lesions, and incidence of nongastrointestinal CMV disease in this patient population.

Completed17 enrollment criteria

The Optimization of a Low-dose CT Protocol in Patients With Suspected Uncomplicated Acute Appendicitis...

AppendicitisOther and Unspecified Acute Appendicitis3 more

This study focuses on the use of contrast enhanced low-dose CT imaging as a modality to differentiate between uncomplicated and complicated acute appendicitis. Accurate differential diagnosis allows the assessment of all available treatment options. Complicated acute appendicitis requires emergency appendectomy, while uncomplicated acute appendicitis can be safely and efficiently treated with antibiotics in the majority of patients. Our study group already published the results of the initial OPTICAP trial enrolling patients with BMI under 30 showing similar accuracy between the low-dose and the stadard dose CT, but a significant dose reduction associated with the low-dose CT. All patients will undergo both imaging protocols as the standard CT is also optimized for a low as possible radiation dosage and imaging sequence per patient is randomized due to the optimization of contrast media injection timing. All patients participating in this study will be treated operatively with a laparoscopic appendectomy to obtain histological confirmation for the diagnosis to evaluate the accuracy of the CT imaging. The aim of this study is to optimize a well-performing low-dose CT imaging protocol to use in the diagnosis of uncomplicated acute appendicitis in patients with body mass index over 30 kg/m2.

Suspended11 enrollment criteria

Prospective Study on the Value of Subcutaneous Drains in Gastrointestinal Surgery

Digestive System Diseases [C06]Digestive System Neoplasms [C04.588.274]

The aim of the study is to determine wether subcutaneus suction drain (type redon-drain) protect against surgical side infection by laparotomy in general surgery.

Completed7 enrollment criteria

Gastric Gluten-Degradation Activity of PvP001

Digestive System Disease

This is a single blind, dose escalating, placebo-controlled, crossover study of gluten-degrading drug PvP001 administered to healthy volunteers (age 18-64 years). Subjects will be randomized to one of three groups representing different levels of gluten exposure - low, medium, or high - in a single meal. Within each gluten exposure group, increasing doses of PvP001 (or placebo) will be administered.

Terminated18 enrollment criteria
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