Efficacy and Safety of Adjunctive Zonisamide in Myoclonic Seizures Associated With Idiopathic Generalised...
EpilepsyThis study is intended to provide evidence that zonisamide is safe and effective in the treatment of myoclonic seizures. The total planned trial duration will be 6.5 months. After that, subjects who have completed the study will be eligible to enroll in an open-label extension study until zonisamide is marketed for this indication or further development in this indication stops. This extension study will be described in a separate protocol (E2090-E044-318).
Long-term Cardiac Monitoring in Epilepsy
Focal EpilepsyIntractable Epilepsy4 moreThe purpose of this research study to investigate, classify, and quantify chronic cardiac rhythm disorders in three groups of patients with epilepsy (intractable focal epilepsy, controlled focal epilepsy and symptomatic generalized epilepsy). Patients with epilepsy have a higher risk for cardiac complications than the general population. With this study, we aim to understand more about these potential complications in patients with epilepsy and assess if treatments for cardiac problems should be evaluated more carefully in patients with epilepsy.
Clobazam in Patients With Lennox-Gastaut Syndrome
EpilepsyEpilepsy2 moreThe purpose of this study is to evaluate the safety and efficacy of clobazam as adjunctive therapy in the treatment of seizures which lead to drop attacks (drop seizures) in patients 2 to 60 years of age with Lennox-Gastaut Syndrome (LGS). Patients will be enrolled at approximately 65 sites in the U.S. and ex-US for up to 23 weeks. Patients will be randomly assigned to either a low, medium or high dose, or placebo. The study will include a baseline period, a titration period and a maintenance period. After the maintenance period, patients will either continue into an open-label extension study or enter the taper period with a final visit 1 week after the last dose.
Prospective Pilot Study on Metabolism and Weight Changes in Topiramate-Treated Epilepsy Patients...
EpilepsyEpilepsies4 moreThe purpose of this study is to assess a possible predictor for weight loss seen in epilepsy patients treated with topiramate.
Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients...
EpilepsyTonic-ClonicThis study is being conducted to compare the efficacy and safety of LAMICTAL (lamotrigine) extended-release with placebo in the treatment of Primary Generalized Tonic-Clonic (PGTC) seizures. LAMICTAL extended-release is an investigational drug. Placebo tablets look like LAMICTAL extended-release tablets but do not contain active medication. In this study, LAMICTAL extended-release or placebo tablets will be added to current seizure treatments.
Microburst Vagus Nerve Stimulator (VNS) Therapy Feasibility Study
EpilepsiesPartial2 moreEvaluate the initial safety and effectiveness of Microburst VNS stimulation in subjects with refractory epilepsy.
Modified Atkins Diet Treatment for Adults With Drug-resistant Epilepsy
EpilepsyFocal Epilepsy1 moreIn Oslo University Hospital, department of complex epilepsy, offer ketogenic diet to treat children with medically intractable epilepsy. From 2009 we added modified Atkins diet as a treatment option for children up to 18 years. We now initiate an open, prospective, randomized and controlled study with the aim to test the efficacy of treatment with modified Atkins diet in adults with focal and generalized epilepsy diagnoses, in order to evaluate whether this treatment should be offered to patients on a permanent basis.
Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who...
SeizuresEpilepsies6 moreTo evaluate the efficacy and safety of diazepam in the management of refractory epilepsy in selected patients who require intermittent medical intervention for the control of episodes of acute repetitive seizures. In addition, to assess the support provided by caregivers who are not themselves or not under the direct supervision of health care professionals at the time of administration.
Levetiracetam as add-on Treatment of Myoclonic Jerks in Adolescents + Adults
Generalized Convulsive EpilepsyA double-blind, placebo-controlled study to assess the efficacy of adjunctive treatment with LEV 3000mg/day in reducing myoclonic seizures in adolescents and adults suffering from idiopathic generalised epilepsy and to evaluate the safety of LEV in the same population.
Treatment Of Primary Generalized Tonic-Clonic Seizures With An Investigational New Drug
EpilepsyTonic-ClonicThe purpose of this study is to evaluate the effectiveness and safety of an investigational new drug for supplemental therapy in subjects with primary generalized tonic-clonic (PGTC) seizures.