Phase I Trial of Oral Metronomic Topotecan and Oral Pazopanib to Treat Recurrent/Persistent Gynecologic...
Gynecologic TumorsThis is a Phase 1, dose-escalation study in female patients with recurrent or persistent gynecologic tumors.
Treatment for Patients With Gynecological Malignancies Who Suffer From Anemia Due to Chemotherapy...
Gynecological MalignanciesGenital Neoplasms2 moreThe purpose of this study is to validate a Patient Satisfaction Questionnaire for Anemia Treatment (PSQ-AT) in gynecological cancer patients treated with darbepoetin alfa or recombinant human erythropoietin (rHuEPO) for anemia due to chemotherapy.
rhTPO Mobilized Auto Cryo Platelets For GYN Patients Receiving Carboplatin
NeoplasmsGynecologicA Pilot Study of Transfusion of rhTPO-Derived Autologous Platelets Cryopreserved with ThromboSol and 2% DMSO in Patients with Gynecologic Malignancy Receiving Carboplatin
Remote Telemonitoring of Patient-Generated Physiologic Health Data and Patient-Reported Outcomes...
Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8170 moreThis study examines at-home monitoring of patient-generated phsyiologic health data and patient-reported outcomes. Patient-generated health data using at-home monitoring devices and smart device applications are used more and more to measure value and quality in cancer care. This trial may show whether at-home monitoring programs can improve the care of patients after hospital discharge from surgery.
Thromboprophylaxis After Surgery for Gynecologic Malignancy in China
Gynecologic NeoplasmsVenous Thromboembolism2 moreVenous thromboembolism (VTE) is an important cause of post-operative morbidity and mortality in women undergoing surgery for gynecologic malignancies. Although the benefit of thromboprophylaxis in reduction of post-operative VTE events after surgery for gynecologic cancers has been well documented around the world, the evidence for Chinese women is rare. The investigators designed this prospective and randomized study to assess the benefit of pharmacologic prophylaxis for patients received surgical treatment for gynecologic malignancies in China.
Lenvatinib and Capecitabine in Patients With Advanced Malignancies
Advanced CancerMalignant Neoplasm of Breast12 moreThere are 2 phases in this study: Phase 1 (dose escalation) and Phase 2 (dose expansion). The goal of Phase 1 of this clinical research study is to find the highest tolerable dose of lenvatinib and Xeloda (capecitabine) that can be given to patients with advanced cancer. The goal of Phase 2 of this study is to learn if the dose of lenvatinib and capecitabine found in Phase 1 can help to control advanced cancer. The safety of this drug combination will be studied in both phases of the study.
Alisertib and TAK-228 in Participants With Human Papilloma Virus (HPV) Associated Malignancies
Malignant Neoplasms of Digestive OrgansMalignant Neoplasms of Female Genital Organs2 moreThe goal of this clinical research study is to find the highest tolerable dose of the combination of alisertib and TAK-228 that can be given to participants with advanced solid tumors that are associated with HPV. Researchers also want to learn if the study drug combination can help to control advanced solid tumors.
Efficacy of Paxman Scalp Cooling to Prevent Chemo Induced Alopecia in Black Patients With Breast...
Breast CancerOvarian Cancer2 moreThis study will measure the efficacy of scalp cooling with the Paxman Scalp Cooling (PSC) device in a diverse patient population with success measured as prevention of more than 50% hair loss during chemotherapy. We propose that scalp cooling has distinct efficacy in participants with black or ethnic-minority hair types due to differences in textures, hair thickness. This study will examine the success rate of scalp cooling in black patients receiving chemotherapy for breast or gynecological cancer.
Safety of Regular Diet as the First Meal in Patients Who Underwent Surgical Treatment for Gynecologic...
Gynecologic NeoplasmsThe purpose of this study is to determine whether it is safe to give a regular diet as the first postoperative meal in patients who underwent surgical treatment for clinically early-stage gynecologic cancer.
Pneumoperitoneum Management With Low vs. Higher Pressure
Malignant Neoplasms of Female Genital OrgansThe goal of this clinical research study is to compare the level of pain 2 hours after surgery in patients after the use of the AirSeal® Insufflation System (AIS) at a high or low pressure setting or the standard insufflator (the conventional insufflation system, or CIS). "Insufflation" is the creation of a pressure barrier of air/gas within the abdomen that allows the surgeon more space to work in.