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Active clinical trials for "Neoplasms, Glandular and Epithelial"

Results 51-56 of 56

A Study of Overall Survival in Participants With Unresectable Hepatocellular Carcinoma

CarcinomaHepatocellular4 more

The primary purpose of this study to continue follow-up of participants enrolled in the study E7080-M081-504 (NCT03663114) of lenvima capsules and to evaluate the overall survival of participants with hepatocellular carcinoma.

Completed6 enrollment criteria

Vorasidenib Expanded Access Program

GliomaRecurrence13 more

This is an expanded access program to provide vorasidenib for treatment of patients 12 years or older with IDH1- or IDH2-mutated glioma.

Available14 enrollment criteria

Optimum Timing for Surgery After Pre-operative Radiotherapy 6 vs 12 Weeks

Adenocarcinoma of the RectumAdenocarcinoma20 more

The aim of this study is to determine whether greater rectal cancer downstaging and regression occurs when surgery is delayed to 12 weeks after completion of radiotherapy/chemotherapy compared to 6 weeks. Hypothesis: Greater downstaging and tumour regression is observed when surgery is delayed to 12 weeks after completion of CRT compared to 6 weeks.

Unknown status9 enrollment criteria

Low Rectal Cancer Study (MERCURY II)

AdenocarcinomaAdenocarcinoma19 more

The MERCURY Study demonstrated the accuracy, feasibility and reproducibility of Magnetic Resonance Imaging (MRI) to stage rectal cancer in a prospective, multidisciplinary, multi-centre study. However, there were differences in patient outcome, dependent upon the position of the tumour in the rectum and its height above the anal verge. Whilst the outcome was excellent for patients who underwent an anterior resection, the outcome, based upon margin involvement and quality of the specimen, was poor for patients who underwent an abdomino-perineal excision for low rectal cancer. It is proposed that accurate MRI staging pre-operatively will allow the correct patients to receive neo-adjuvant chemoradiotherapy (CRT), and also pre-warn the surgeons if the resection margins appear threatened so that the operation can be modified to take this into account. The primary aims of the Low Rectal Cancer Study (MERCURY II) are to assess the rate of CRM positivity rate in low rectal cancer and to assess the difference in global quality of life at two years post surgery in patients according to plane of surgery with or without sphincter preservation.

Unknown status8 enrollment criteria

Preoperative Prediction of of Thymic Epithelial Tumors by Diffusion-Weighted MR Imaging

Thymic Epithelial Tumor

The aim of this study is to analyze aquaporins expression of thymic epithelial tumors and to compare them with apparent diffusion coefficient(ADC) from ultra-high b-values, and to test a possibility of use of ADCuh to identify the pathological type of tumor.

Unknown status5 enrollment criteria

Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural...

AdenocarcinomaRectal Diseases19 more

Extramural venous invasion (EMVI) is the spread of microscopic tumour cells into the veins around the tumour. Rectal cancer treatment has improved greatly over recent years. However, it is important for us to learn as much about the tumours as possible in order to develop newer therapies. Current treatments may benefit from new genetic information relating to the cancer. We hope to identify genetic differences in certain types of rectal cancer which will allow future treatments.

Unknown status8 enrollment criteria
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