Vaccine Therapy in Treating Young Patients Who Are Undergoing Surgery for Malignant Glioma
Brain and Central Nervous System TumorsRATIONALE: Vaccines made from a person's white blood cells and tumor cells may help the body build an effective immune response to kill tumor cells. Giving vaccine therapy after surgery may be a more effective treatment for malignant glioma. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating young patients who are undergoing surgery for malignant glioma.
Sorafenib in Treating Patients With Recurrent or Progressive Malignant Glioma
Adult Anaplastic AstrocytomaAdult Anaplastic Oligodendroglioma3 moreThis phase I trial is studying the side effects and best dose of sorafenib in treating patients with recurrent or progressive malignant glioma. Sorafenib may stop the growth of tumor cells by stopping blood flow to the tumor and by blocking the enzymes necessary for their growth.
Gimatecan in Treating Patients With Recurrent or Progressive Primary Malignant Glioma
Brain and Central Nervous System TumorsRATIONALE: Drugs used in chemotherapy, such as gimatecan, work in different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase I/II trial is studying the side effects and best dose of gimatecan in treating patients with recurrent or progressive primary malignant glioma.
Vaccine Therapy in Treating Patients With Malignant Glioma
Brain and Central Nervous System TumorsRATIONALE: Vaccines made from a person's white blood cells mixed with tumor proteins may make the body build an immune response to kill tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating patients with malignant glioma.
Prolonged Daily Temozolomide for Low-Grade Glioma
GliomaAstrocytoma1 moreThe purpose of this trial is to determine the effects (good and bad) temozolomide has on patients with low-grade glioma. It will also determine whether temozolomide is effective in preventing or delaying future tumor growth.
Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma
Adult Anaplastic AstrocytomaAdult Anaplastic Oligodendroglioma9 moreErlotinib and temsirolimus and may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. This phase I/II trial is studying the side effects and best dose of temsirolimus when given together with erlotinib and to see how well they work in treating patients with recurrent malignant glioma.
Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic...
Brain TumorCentral Nervous System TumorRATIONALE: Drugs used in chemotherapy, such as carboplatin, vincristine, and temozolomide, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving more than one drug may kill more tumor cells. PURPOSE: This pilot study is studying giving carboplatin and vincristine together with temozolomide in treating children with progressive and/or symptomatic low-grade glioma.
Tipifarnib and Radiation Therapy in Treating Young Patients With Brainstem Glioma
Untreated Childhood Brain Stem GliomaTipifarnib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. Radiation therapy uses high-energy x-rays to damage tumor cells. Tipifarnib may make tumor cells more sensitive to radiation therapy. Combining tipifarnib with radiation therapy may kill more tumor cells. This phase I/II trial is studying the side effects and best dose of tipifarnib to see how well it works when given together with radiation therapy in treating young patients with newly diagnosed brain stem glioma. (Phase I closed to accrual as of 1/19/06)
Chemotherapy in Treating Patients With Recurrent Malignant Glioma
Brain and Central Nervous System TumorsRATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of topotecan plus carmustine in patients with recurrent primary malignant glioma.
Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors
Childhood Central Nervous System Germ Cell TumorChildhood Choroid Plexus Tumor23 morePhase I trial to study the safety of combining O6-benzylguanine with temozolomide in treating children who have recurrent or refractory brain tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. O6-benzylguanine may increase the effectiveness of temozolomide by making tumor cells more sensitive to the drug.