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Active clinical trials for "Glucose Metabolism Disorders"

Results 91-100 of 203

Health Effects of Biostimulated Lettuce in Human

NutritionHealthy5 more

The aim of the project is to study the influence of biostimulate crops on a healthy population in order to assess influence on hematological parameters and specific metabolism (glucose, lipid, iron, bone) and gut and lipid hormones. Secondary outcome will be to find out micronutrient presence in urine and serum. The use of biostimulation in modern agriculture has rapidly expanded in recent years, owing to their beneficial effects on crop yield and product quality, which have come under the scope of intensive research.

Completed9 enrollment criteria

Modified Whey Protein and Effect on Post Meal Glucose Levels Study

Metabolism DisorderGlucose

After meals, the level of glucose rises in the circulation. In some individuals who are overweight and older, blood glucose can rise to levels which can damage tissues and cause health problems. Usually the hormone insulin, released from the pancreas, effectively lowers blood glucose. However, in overweight and older people insulin is less effective. Certain foods can lower the rise in blood glucose, particularly proteins. This works by increasing the release of a hormone from the gut called Glucagon-Like Peptide 1 (GLP-1), which in turn increases the release of insulin. A Component of milk left over after cheese making, termed Whey protein, is particularly good at releasing GLP-1. Whey protein is used as a food additive and taken as a supplement to help build muscle. Whey protein is a mixture of proteins which the investigators have modified to be more effective at lowering blood glucose. Using laboratory tests the investigators identified a protein present in Whey that does not increase levels of GLP-1 and removed it. It's removal raises the levels of other proteins which are more effective. In this study, the investigators would like to test the effectiveness of the "modified" whey protein. To do this, 30 older, overweight volunteers will be recruited and given the modified whey protein, a normal whey protein or a mixture of amino acids and then a breakfast meal to raise their blood glucose levels. These drinks will be given in a randomised sequence 1 week apart. On each visit, blood samples to measure blood glucose and related hormone levels will be taken. As GLP-1 can also have an effect on appetite, the investigators will measure the effect of the modified whey protein on subsequent appetite in the volunteers by asking them how hungry they feel.

Completed10 enrollment criteria

Efficacy and Safety of 12-weeks Supplementation of Eubacterium Hallii on Insulin Sensitivity and...

Pre DiabetesImpaired Glucose Tolerance4 more

This 12 week placebo-controlled study evaluates the efficacy and safety of E. hallii supplementation.

Completed31 enrollment criteria

Aldosterone and the Metabolic Syndrome

Metabolic DiseasesDiabetes Mellitus2 more

The purpose of this study is to determine the effects of mineralocorticoid receptor (MR) antagonism and renin inhibition on glucose metabolism in humans.

Completed41 enrollment criteria

Pioglitazone in Impaired Glucose Tolerance

Glucose Metabolism Disorders

In patients with impaired glucose tolerance (IGT), the researchers want to study the relative effects of pioglitazone, simvastatin, or the combination of both on: intima media thickness (IMT) as an easily assessed marker of atherosclerosis heart rate variability (HRV) as a marker of autonomic neuropathy flow-mediated vasodilatation (FMD) of the brachial artery as a marker of endothelial function vascular and metabolic lab parameters

Withdrawn10 enrollment criteria

Acarbose and Secondary Prevention After Coronary Stenting

Glucose Metabolism DisordersCoronary Artery Disease

The purpose of this study is to determine whether the intervention for newly diagnosed abnormal glucose tolerance after coronary stenting will improve the long-term clinical outcome.

Completed18 enrollment criteria

The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia...

Metabolic Syndrome XAtherosclerosis8 more

The purpose of this study is to investigate the effect of interrupting prolong sedentary behavior with interval exercise on postprandial metabolism following a high fat glucose tolerance test.

Completed6 enrollment criteria

Impact of Meal Order on Postprandial Cardiometabolic Risk Markers

Metabolic Syndrome XInsulin Resistance3 more

The order in which the different components of a meal are eaten may have impact on the postprandial metabolic responses to carbohydrates, fat and proteins. This study will compare blood lipids and glycemia regulation following lunches of identical composition but varying the order of intake of the different meal components.

Completed6 enrollment criteria

Efficacy and Safety of Dasiglucagon for Treatment of Post-bariatric Hypoglycemia in Roux-en-Y Gastric...

HypoglycemiaGlucose Metabolism Disorders

The objective of the trial is to assess the effect of single subcutaneous doses of dasiglucagon versus placebo on post-prandial plasma glucose nadir following a Mixed Meal Test in Roux-en-Y Gastric Bypass (RYGB) subjects

Withdrawn14 enrollment criteria

Comparison of A New Technique of Measure of the Insulin Resistance By Scintigraphy With the Reference...

Diabetes MellitusInsulin Resistance3 more

Insulin resistance is closely associated with apparition of type 2 diabetes mellitus; it is an independent risk factor and predicts future cardiovascular events. Hyperinsulinemic euglycemic clamp is a validated method to assessment of insulin resistance and It is also the gold standard technique. However, the complexity and length of this technique render it unsuitable for routine clinical use. In this study, the investigators use a new technique to provide precise, objective, fast and automated quantification of insulin resistance with camera SPECT. They compare the results with those of the measurement of hyperinsulinemic euglycemic clamp in population with or without insulin resistance. The proposed study is to validate this new non-invasive imaging technique for evaluation of insulin resistance in patients with or without insulin resistance with a comparison with hyperinsulinemic euglycemic clamp.

Completed26 enrollment criteria
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