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Active clinical trials for "Graves Ophthalmopathy"

Results 1-10 of 119

Efficacy and Safety of Tocilizumab for TAO

TocilizumabThyroid Associated Ophthalmopathy

This study aims to evaluate the efficacy and safety of tocilizumab treating Thyroid Associated Ophthalmopathy.

Recruiting13 enrollment criteria

A Randomized, Double-masked, Placebo-controlled Safety, Tolerability, and Efficacy Study of VRDN-001,...

Thyroid Eye Disease

A randomized, double-masked, placebo-controlled safety, tolerability and efficacy study of VRDN-001 in participants with chronic thyroid eye disease (TED)

Recruiting14 enrollment criteria

Study to Assess Batoclimab in Participants With Active Thyroid Eye Disease

Thyroid Eye Disease

To evaluate the efficacy of batoclimab 680 milligrams (mg) subcutaneous (SC) once a week (QW) for 12 weeks followed by 340 mg SC QW for 12 weeks versus placebo on proptosis responder rate at Week 24.

Recruiting19 enrollment criteria

Efficacy and Safety of Lonigutamab in Subjects With Thyroid Eye Disease (TED)

Thyroid Eye Disease

Phase 1/2, multicenter, multiple dose clinical study designed to evaluate lonigutamab in subjects with TED.

Recruiting18 enrollment criteria

Study of Therapeutic Value of Periorbital Injection of Glucocorticoid in Mild TAO

Thyroid Associated Ophthalmopathy

The purpose of this study is to determine whether periorbital injection of glucocorticoid is effective and necessary in the treatment of mild TAO.

Recruiting24 enrollment criteria

Anti-VEGF Therapy for Acute Thyroid Eye Disease

Thyroid Eye Disease

The primary objective of this clinical trial is to assess the safety and tolerability of sub-tenon aflibercept in combination with either saline or hyaluronidase (HA) in patients with acute Thyroid Eye Disease (TED) as assessed by the incidence and severity of adverse events from baseline to day 45. Participants will undergo clinical examinations and receive three injections of aflibercept with saline, aflibercept with hyaluronidase, or hyaluronidase.

Recruiting26 enrollment criteria

A Safety, Tolerability and Efficacy Study of VRDN 001 in Healthy Volunteers and Persons With Thyroid...

Thyroid Eye Disease

The investigational drug, VRDN-001, is a monoclonal antibody that inhibits the activity of a cell surface receptor called insulin-like growth factor-1 receptor (IGF-1R). Inhibition of IGF-1R may help to reduce the inflammation and associated tissue swelling that occurs in patients with thyroid eye disease (TED). This clinical trial will evaluate the safety, tolerability and pharmacokinetics (the concentration of drug in the blood over time) of VRDN-001 in healthy volunteers and in patients with TED. Study participants with TED will also be evaluated over time for changes in their signs and symptoms of TED compared to their baseline measurements.

Recruiting35 enrollment criteria

Evaluation of the Efficacy and Safety of 3D Printing for Orbital Surgery.

Thyroid Associated OphthalmopathySurgical Procedure1 more

This is a multicentric, randomized, single-blinded clinical trial to evaluate the efficacy and safety of 3D printing for the planification and simulation of orbital decompression surgery for thyroid-associated orbitopathy.

Recruiting7 enrollment criteria

Hydroxychloroquine in Mild Graves' Orbitopathy

Graves Ophthalmopathy

This study is aimed to investigate the effect of hydroxychloroquine in patients with mild Graves' orbitopathy (GO).

Recruiting19 enrollment criteria

Tamsulosin for Thyroid Lid Retraction

Thyroid Eye DiseaseEyelid Diseases

The purpose of this study is to examine the effect of using Tamsulosin for treatment of eyelid retraction as part of thyroid eye disease. The treatment will be offered to all thyroid patients suffering from eyelid retraction who are treated at the thyroid clinic in Sheba's Ophthalmology department. All patient will receive information about the drug Tamsulosin, the possible side effects, and the alternative treatment options for retraction. Patients recruited will take 0.4mg/day Tamsulosin for 3 months and will have follow-ups at 1 week, 1 month and 3 months to evaluate the retraction status.

Recruiting3 enrollment criteria
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