Efficacy and Safety of Tocilizumab for TAO
TocilizumabThyroid Associated OphthalmopathyThis study aims to evaluate the efficacy and safety of tocilizumab treating Thyroid Associated Ophthalmopathy.
A Randomized, Double-masked, Placebo-controlled Safety, Tolerability, and Efficacy Study of VRDN-001,...
Thyroid Eye DiseaseA randomized, double-masked, placebo-controlled safety, tolerability and efficacy study of VRDN-001 in participants with chronic thyroid eye disease (TED)
Study to Assess Batoclimab in Participants With Active Thyroid Eye Disease
Thyroid Eye DiseaseTo evaluate the efficacy of batoclimab 680 milligrams (mg) subcutaneous (SC) once a week (QW) for 12 weeks followed by 340 mg SC QW for 12 weeks versus placebo on proptosis responder rate at Week 24.
Efficacy and Safety of Lonigutamab in Subjects With Thyroid Eye Disease (TED)
Thyroid Eye DiseasePhase 1/2, multicenter, multiple dose clinical study designed to evaluate lonigutamab in subjects with TED.
Study of Therapeutic Value of Periorbital Injection of Glucocorticoid in Mild TAO
Thyroid Associated OphthalmopathyThe purpose of this study is to determine whether periorbital injection of glucocorticoid is effective and necessary in the treatment of mild TAO.
Anti-VEGF Therapy for Acute Thyroid Eye Disease
Thyroid Eye DiseaseThe primary objective of this clinical trial is to assess the safety and tolerability of sub-tenon aflibercept in combination with either saline or hyaluronidase (HA) in patients with acute Thyroid Eye Disease (TED) as assessed by the incidence and severity of adverse events from baseline to day 45. Participants will undergo clinical examinations and receive three injections of aflibercept with saline, aflibercept with hyaluronidase, or hyaluronidase.
A Safety, Tolerability and Efficacy Study of VRDN 001 in Healthy Volunteers and Persons With Thyroid...
Thyroid Eye DiseaseThe investigational drug, VRDN-001, is a monoclonal antibody that inhibits the activity of a cell surface receptor called insulin-like growth factor-1 receptor (IGF-1R). Inhibition of IGF-1R may help to reduce the inflammation and associated tissue swelling that occurs in patients with thyroid eye disease (TED). This clinical trial will evaluate the safety, tolerability and pharmacokinetics (the concentration of drug in the blood over time) of VRDN-001 in healthy volunteers and in patients with TED. Study participants with TED will also be evaluated over time for changes in their signs and symptoms of TED compared to their baseline measurements.
Evaluation of the Efficacy and Safety of 3D Printing for Orbital Surgery.
Thyroid Associated OphthalmopathySurgical Procedure1 moreThis is a multicentric, randomized, single-blinded clinical trial to evaluate the efficacy and safety of 3D printing for the planification and simulation of orbital decompression surgery for thyroid-associated orbitopathy.
Hydroxychloroquine in Mild Graves' Orbitopathy
Graves OphthalmopathyThis study is aimed to investigate the effect of hydroxychloroquine in patients with mild Graves' orbitopathy (GO).
Tamsulosin for Thyroid Lid Retraction
Thyroid Eye DiseaseEyelid DiseasesThe purpose of this study is to examine the effect of using Tamsulosin for treatment of eyelid retraction as part of thyroid eye disease. The treatment will be offered to all thyroid patients suffering from eyelid retraction who are treated at the thyroid clinic in Sheba's Ophthalmology department. All patient will receive information about the drug Tamsulosin, the possible side effects, and the alternative treatment options for retraction. Patients recruited will take 0.4mg/day Tamsulosin for 3 months and will have follow-ups at 1 week, 1 month and 3 months to evaluate the retraction status.