search

Active clinical trials for "Head and Neck Neoplasms"

Results 1471-1480 of 1835

A Pilot Study of the Use of the DaVinci Robotic System for Otorhinolaryngology-Head and Neck Surgery...

Head and Neck Neoplasms

Patients included will have benign or malignant lesions with treatment plan for endoscopic resection or resection by other minimally invasive techniques. They will be offered a robotic approach to their surgery using the DaVinci robotic surgical system (intuitive Surgical, Inc.). The objectives are to evaluate our ability to adequately visualize the surgical field and perform the intended surgery without a higher complication rate. Secondary objective include evaluation of blood loss, length of hospital stay, complications while using the DaVinci robot system, and quality of life in subjects and historical controls undergoing similar surgery without the robot or radiation therapy. To evaluate recurrence, survival and other outcome data in robotic surgery patients compared with similar historical control groups (matched with respect to stage, prior and subsequent treatment, age, tumor HPV positivity) of patients who have undergone standard surgery without the robot or radiation/chemoradiation treatment as an alternative to surgery. 5. Endpoints will be compared to historical controls.

Unknown status7 enrollment criteria

The ARTERY FIRST Approach for Resection of Pancreatic Head Cancer

Pancreatic Head Cancer

To show whether the artery first approach leads to equal or less rate of positive resection margins in pancreatic head cancer than the standard technique (ppWhipple only with standard Kocher's manoeuvre)

Unknown status8 enrollment criteria

Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study

Breast CarcinomaDigestive System Neoplasm9 more

This phase I trial collects blood samples to investigate the prevalence of changes in genes (genetic mutations) in solid tumor patient populations seeking care at Mayo Clinic Embedded Cancer Center at St. Vincent's Riverside. This may help doctors better understand and/or treat others who have genetic mutations.

Completed6 enrollment criteria

Paracetamol With or Without Ketoprofen in the Management of Pain for Patients Receiving Brachytherapy...

Uterine Cervical CancerUpper Aerodigestive Tract Neoplasms

The results of the study will permit to set up a standardized and validated procedure of pain management authorizing medical and paramedical staff of brachytherapy department to handle pain and in this way to improve the quality of life of the patients.

Unknown status23 enrollment criteria

DNA Repair Enzyme Signature in Head and Neck Cancer (CHEMRAD)

Head CancerNeck Cancer

Squamous cell carcinoma (HNSCC) is the most frequent form of head and neck cancer. The therapeutic choice depends on the stage of the disease and the habits of the medical teams. Surgery, radiotherapy and chemotherapy can be used, alone or combined. However, none of the existing strategies has proven its superiority. Chemotherapy and radiotherapy induce DNA damages in the tumor cells. However, cells have the ability to induce DNA reparation, capable of causing treatment resistance. DNA reparation in non-tumor tissues can also explain the toxicity of cancer treatments. Investigation of DNA repair pathways involved in chemo- or radiation resistance could offer a good strategy for identifying biomarkers or indicators of treatment response. This study will explore the capacity of a comprehensive functional approach that addresses several pathways, based on the use of three innovative patented technologies, to classify the tumor response of HNSCC patients to treatments according to their DNA Repair Enzyme Signature. Our hypothesis is that taking into account various clinical parameters (e.g. patient and tumor characteristics), treatment strategy and measuring the DNA Repair Enzyme Signature would create patients' profiles and optimize their management.

Completed15 enrollment criteria

Reproducibility of Intratumor Distribution of 18F-EF5 in Head and Neck Cancer

Squamous Cell Carcinoma of the Head and Neck

The results of previous studies suggest further development of [18F]EF5 as a PET tracer for imaging hypoxia. This is a non-randomized prospective study to obtain information on reproducibility of [18F]EF5 intratumor distribution using repeated pretreatment PET/CT scans.

Completed11 enrollment criteria

Assessment of Cellular Proliferation in Tumors by Positron Emission Tomography (PET) Using [18F]ISO-1...

Breast CancerHead and Neck Cancer1 more

The main purpose of this study is to see if Positron Emission Tomography (PET) imaging with a radioactive tracer called 18F-ISO-1 can accurately identify how quickly cancer cells are growing or dividing. A second purpose for this study is to determine, by taking pictures, what tissues and organs of the body take up 18F-ISO-1 naturally and to determine how that uptake changes over time.

Completed7 enrollment criteria

Evaluation of 3DCRT Versus IGRT and Analysis of Early Response in Head and Neck Cancer.

HEAD AND NECK CANCERCARCINOMA OROPHARYNX2 more

This study aims to study the impact image guided radiotherapy with Cone beam CT will have on the outcomes(toxicities and response) of head and neck cancer when compared to 3D conformal radiotherapy without CBCT based setup error verification.Also,the various dosimetric variations in Adaptive RT will be studied.

Unknown status6 enrollment criteria

Randomised Study of Mucositis Prevention After Radiochemotherapy Treatment for Head and Neck Cancer...

Severe Acute MucositisHead and Neck Cancer

This randomised, double-blind study will compare an oral immunomodulatory solution to a placebo for the prevention of acute severe mucositis in head and neck cancer patients treated surgically and concomitantly with radiochemotherapy. The investigators expect a decrease of 25% of severe acute mucositis in experimental arm.

Completed23 enrollment criteria

Comparison of Tumor Glucose Metabolism Before and After Artificial Nutrition

Head and Neck CancerOesophageal Cancer

Evaluate the feasability to determine the difference of tumoral metabolism before and after artificial nutrition.

Completed8 enrollment criteria
1...147148149...184

Need Help? Contact our team!


We'll reach out to this number within 24 hrs