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Active clinical trials for "Head and Neck Neoplasms"

Results 791-800 of 1835

Smoking Cessation in Head and Neck Cancer Patients Receiving Curative Radiation Therapy

Head and Neck Neoplasms

To propose a feasibility study of introducing a smoking cessation program in head and neck cancer patients with planned radiotherapy. The study will feature the feasibility, safety, and efficacy of a prospective smoking cessation program during head and neck irradiation.

Completed8 enrollment criteria

Evaluation of ABEMACICLIB Monotherapy in Patients With Locally Advanced/Metastatic Head and Neck...

Head and Neck CancerAdvanced Cancer1 more

This trial is an open-label, single arm, Phase II study using an A'Hern single stage design. The molecular prescreening step will allow to defined HPV tumor status as well as molecular status CDKN2A, CCND1 and CDK6. Following this centralized molecular screening, only patients with HPV negative status and with tumor harboring CDKN2A homozygous deletion and/or CCND1 amplification and/or CDK6 amplification could initiate abemaciclib at time of documented radiological progression. Patients will be treated with ABEMACICLIB, 400 mg/day with 2 doses of 200 mg 12 hour apart (QH12). A cycle is defined as an interval of 28 days. For each 28-day cycle, a total of 56 doses of study drug will be dispensed.

Completed52 enrollment criteria

Afatinib and Pembrolizumab for Head and Neck Squamous Cell Carcinoma (ALPHA Study)

Head and Neck Neoplasms

The primary objectives of the trial is to examine the toxicities and efficacies of afatinib and pembrolizumab for recurrent and/or metastatic head and neck squamous cell carcinoma.

Completed35 enrollment criteria

The Addition of Pembrolizumab to Postoperative Radiotherapy in Cutaneous Squamous Cell Cancer of...

Squamous Cell Carcinoma of the Head and Neck

A small group of skin cancers of the head and neck, called resected cutaneous squamous carcinomas, are more aggressive than most cancers of this type, even after being treated with standard therapy. This trial will use stronger treatment to look at the safety and effectiveness (efficacy) of combining a drug called Pembrolizumab with radiation after a cancer has already been treated to suppress secondary tumor formation in high risk cutaneous squamous cell cancer of the head and neck. Primary Objective To assess safety by looking at the people with dose limiting responses

Completed44 enrollment criteria

Neck Drains for SLNDs

Neck DiseaseHead and Neck Cancer

This is a single-blinded randomized controlled trial to compare the outcomes of early closed suction drain removal versus output volume-based drain removal after selective lateral neck dissections (SLND). The main hypothesis of the study is that the early drain removal of closed suction drains on the first postoperative day is safe compared to the current practice of output volume-based drain removal when output is less than 30ml/24hr or 15ml/12hr. This study will also evaluate the hypotheses that output volume-based drain removal of surgical drains increases inpatient length of stay and decreases the average patient satisfaction score on the measurement of quality of recovery (QoR-40).

Completed13 enrollment criteria

Ruxolitinib in Operable Head and Neck Cancer

Head and Neck Squamous Cell Carcinoma

The purpose of this study is to assess the safety and efficacy of ruxolitinib in patients with operable Head and neck squamous cell carcinoma (HNSCC) who are planned for definitive surgery.

Completed24 enrollment criteria

Moderate Whole Body Hyperthermia for Patients Undergoing Re-irradiation for Head and Neck Cancer...

Head and Neck NeoplasmsRecurrence Tumor

The aim of the study is to determine the feasibility and efficacy of moderate weekly whole Body hyperthermia Treatment during radiochemotherapy for pre-irradiated locally or regionally recurrent head and neck squamous cell carcinomas. The Primary aim of the study is feasibility, defined as 80% of patients completing at least four applications of hyperthermia. Secondary endpoints include an increase of Tumor Perfusion by the use of hyperthermia, measured by magnetic resonance Imaging during week two of Treatment and reduction of Tumor hypoxia, measured by hypoxia specific Positron emission tomography.

Completed9 enrollment criteria

A Trial Looking at Treating Dry Mouth After Radiotherapy for Head and Neck Cancer

XerostomiaHead and Neck Neoplasms

This trial is looking at using an intra-oral electrostimulating device for the management of radiotherapy-induced dry mouth.

Completed14 enrollment criteria

Response to Intermittent Pneumatic Compression Therapy in Head and Neck Cancer-Related Lymphedema...

Head and Neck NeoplasmsHead and Neck Lymphedema1 more

Assessment of lymphatic structure and function pre- and post- treatment and during recovery in head and neck cancer related lymphedema patients using NIR fluorescence lymphatic imaging: Response to ICD therapy in HNC Patients.

Completed22 enrollment criteria

Single-arm Phase II Study of NDURE for Patients With HNC

Cancer of Head and Neck

This study will evaluate whether a new patient navigation intervention can decrease delays starting post-operative radiation therapy after surgery for white and African-American head and neck cancer patients.

Completed13 enrollment criteria
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