Randomized Multicenter Trial of Prehospital Initiated Facilitated Percutaneous Coronary Intervention...
Myocardial InfarctionPrehospital initiated facilitation of primary percutaneous coronary intervention by fibrinolysis might be helpful in re-opening the infarct related artery prior to percutaneous coronary intervention. This studies tests the hypothesis that prehospital initiated facilitated PCI is superior to primary percutaneous coronary intervention with respect to infarct size.
REPAIR-AMI: Intracoronary Progenitor Cells in Acute Myocardial Infarction (AMI)
Myocardial InfarctionImpaired contractile function after a heart attack of the heart is a major cause of "heart failure" limiting quality of life and prognosis, which cannot be prevented even with optimal standard therapy, including immediate balloon/stent dilation of the infarct vessel. The aim of the REPAIR-AMI trial is to investigate whether infusion of progenitor cells into the infarct vessel (after successful reperfusion therapy) may improve left ventricular contractile function compared to placebo therapy. After bone marrow aspiration progenitor cells are enriched via a centrifugation method.
Bone Marrow Stem Cell Mobilisation Therapy for Acute Myocardial Infarction (AMI)(REVIVAL-2)
Myocardial InfarctionThe purpose of this study is to determine whether stem cell mobilization by granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute myocardial infarction after successful mechanical reperfusion reduces infarct size.
Thrombus Aspiration Before Standard Primary Angioplasty Improves Myocardial Reperfusion in Acute...
Acute Myocardial InfarctionIn patients with acute ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) may cause thrombus dislodgment and impaired microcirculatory reperfusion. This study was designed to test the hypothesis that thrombus aspiration before standard PCI may improve acute myocardial reperfusion, measured by ST-segment resolution (STR) and myocardial blush grade (MBG), compared with standard PCI.
Female Sex is an Independent Predictor of Death and Bleeding Among Fibrinolytic Treated Patients...
Myocardial InfarctionThis study evaluated differences between men and women in the presentation, management and outcome of heart attacks within the GUSTO V study.
Aspirin Dose and Atherosclerosis in Patients With Heart Disease
Cardiovascular DiseasesAtherosclerosis1 moreThe purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients who have had a heart attack.
Nurses' Health Study (Cardiovascular Component)
Cardiovascular DiseasesDiabetes Mellitus8 moreTo determine the relationships of hormonal, reproductive, dietary, and lifestyle factors, as well as biochemical and genetic factors, with the subsequent risk of coronary heart disease and other cardiovascular events in a cohort of female registered nurses. The current funding cycle involves comprehensive metabolomic profiling of coronary heart disease cases and controls and development of metabolomic risk scores for coronary heart disease.
Shock Trial: Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock.
Cardiovascular DiseasesCoronary Disease5 moreTo test if early revascularization, primarily with angioplasty (PTCA) or bypass surgery (CABG), reduced all-cause in-hospital mortality from cardiogenic shock compared to conventional treatment, including thrombolysis.
A Multicenter Trial to Assess the MIcrovascular Integrity and Left Ventricular Function Recovery...
Myocardial InfarctionST Segment Elevation Myocardial Infarction (STEMI)This is a prospective randomized study, which investigates the coronary microvascular function as assessed by coronary angiography after administration of ticagrelor compared with clopidogrel in patients with myocardial infarction and ST segment elevation after thrombolysis.
Transcutaneous Electrical Nerve Stimulation Improves Vascular Conductance After Coronary Artery...
Acute Myocardial InfarctionThe investigators will test the hypothesis that transcutaneous electrical nerve stimulation (TENS) may attenuate peripheral vasoconstriction and to improve blood flow redistribution during handgrip exercise in acute myocardial infarction (AMI) patients after Coronary Arterial Bypass Graft Surgery (CABG).