Safety/Tolerability, Pharmacokinetics/Pharmacodynamics (PK/PD) of LCZ696 in Patients With Stable...
Heart FailureThis study assess the safety/tolerability, PK/PD of LCZ696 in patients with stable heart failure.
Safety and Efficacy of Low Dose Hypertonic Saline Solution and High Dose Furosemide for Congestive...
Congestive Heart FailureRenal InsufficiencyThe purpose of this study is to compare high dose furosemide in combination with low volume hypertonic saline solution (2.4%) with intermittent pulse dose furosemide in patients with pre treatment kidney function impairment. The hypothesis is that it will provide effective diuretic response and have a beneficial effect on preservation of renal function as compared to pulse furosemide in patients with pre-treatment renal impairment (GFR < 60 mL/min).
Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With...
Dilated CardiomyopathyThis study is designed to assess the safety profile and the efficacy of cardiac repair cells (CRCs) administered via catheter in treating patients with dilated cardiomyopathy (DCM).
Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)
Chronic Stable Heart FailureThe purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.
Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM...
Congestive Heart FailureA study to evaluate the effect of Atacand on patients with heart failure with depressed left ventricular function
Enteral Nutrition in Congestive Heart Failure and Cardiac Cachexia
Chronic Heart FailureCardiac CachexiaThe purpose of this study was to determine the effects of a high caloric drink on weight and several other clinical markers including quality of life in patients with unintentional weight loss (cachexia) due to chronic heart failure.
Clinical Evaluation on Advanced Resynchronization
Heart FailureCardiomyopathyThe aim of the study is to compare clinical benefits of the cardiac resynchronisation (CRT) achieved by the PEA optimised pacing configuration and a CRT optimised by standard clinical procedure. PEA optimised configuration (PEA-CRT) is obtained, during patient's follow-up, using the Peak Endocardial Acceleration sensor features onboard the device.
Rheos® Diastolic Heart Failure Trial
Diastolic Heart FailureThe CVRx® Rheos® Diastolic Heart Failure Trial is a prospective, randomized, double blind trial with up to 60 subjects conducted at up to five centers in Europe. All subjects will be followed up to one year post implant.
Hemodynamic Effects of Rolofylline in the Treatment of Patients With Heart Failure (7418-503)
Heart FailureThe study will estimate the effects of rolofylline, alone and in addition to loop diuretic therapy on pulmonary capillary wedge pressure and other hemodynamic parameters, in patients with heart failure and renal impairment.
Catheter Ablation vs. Standard Conventional Treatment in Patients With LV Dysfunction and AF
Atrial FibrillationHeart FailureAtrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. The incidence and prevalence of AF increase exponentially with increasing age and AF is associated with higher mortality, more frequent hospitalization, and lower quality of life. Furthermore, AF is often associated with heart failure. The majority of AF is initiated by ectopic foci found primarily in the pulmonary veins. It was shown that catheter ablation of those veins could eliminate episodes of AF. In patients with heart failure, catheter ablation could improve cardiac function, symptoms and quality of life. It remains still unknown whether AF ablation is more effective than conventional treatment in terms of mortality and morbidity.