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Active clinical trials for "Heart Defects, Congenital"

Results 321-330 of 806

Capnography Monitoring in Ventilated Children

ChildOnly12 more

End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.

Active16 enrollment criteria

Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung...

Heart DiseaseCystic Fibrosis1 more

The primary objective of this study is to determine if quantitative Dynamic contrast-enhanced magnetic resonance (DCE MR) perfusion imaging accurately quantifies right and left pulmonary artery blood flow as compared with phase contrast flow velocity mapping (PC), the current gold standard of flow volume measurements.

Completed16 enrollment criteria

Cardiopulmonary Rehabilitation for Adolescents and Adults With Congenital Heart Disease

Congenital Heart DiseaseHeart Defects1 more

The hypothesis of this study is that participation in a formal cardiopulmonary rehabilitation program improves aerobic exercise capacity and quality of life over the medium term for patients with congenital heart disease with reduced exercise capacity. To test this hypothesis, subjects will be randomized to either receive a 12-week cardiopulmonary rehabilitation program or standard of care, with interval testing of aerobic capacity and other physiologic markers improved fitness, as well as assessment of quality of life.

Completed10 enrollment criteria

Intestinal Function in Neonates With Complex Congenital Heart Disease

Congenital Heart DefectsGrowth Failure

Postnatal intestinal function in cardiac infants. The overall goal of this proposal is to address a widespread health problem in the pediatric cardiac infant population - poor postnatal growth - through a collaborative effort between pediatric cardiology, cardiothoracic surgery, neonatology, microbiology, and immunology. The hypothesis is that term neonates with complex congenital heart disease (CHD) who receive trophic breastmilk feeds in the pre-operative period will show improved gut function than neonates who were strictly NPO (nothing by mouth) in the pre-operative period.

Completed8 enrollment criteria

Fresh Frozen Plasma and Plasmalyte ® for Priming Cardiopulmonary Bypass in Infants and Children...

Congenital Heart Disease

Coagulation abnormalities after pediatric open-heart surgery are complex and very often multifactorial. Besides the cardiopulmonary bypass (CPB), the congenital pathology and the coagulation tests during CPB, the younger age has been the most significant risk factor for bleeding and transfusion requirements. In children the volume of pump priming is much higher compared with the patient's circulating blood volume. For this reason the CPB tubing system is primed with packed red blood cells and fresh frozen plasma (FFP) to avoid excessive hemodilution and induced coagulopathy. While this is routinely performed in neonates and small infants, the routine priming of CPB system with FFP has been questioned in several randomized prospective studies in older infants. However, the results of these studies are conflicting. Moreover, they show methodological issues.

Completed5 enrollment criteria

Technical Development for Pediatric Cardiovascular MRI

Congenital Heart DiseaseCardiovascular Disease

This study will explore new ways of using magnetic resonance imaging (MRI) to evaluate pediatric patients with cardiovascular disease,congenital heart disease in patients of all ages, fetuses undergoing clinically indicated MR imaging.

Active33 enrollment criteria

Family Centred Early Intervention of Infants With Congenital Heart Disease

Congenital Heart Disease in Children

In this study the investigators aim to test the feasibility for therapists and acceptability to parents of an early motor intervention for infants with congenital heart disease (CHD) after open heart surgery. This intervention will be compared to the standard care of treatment that is recommended for infants with congenital heart disease at the University Children Hospital Zurich.

Completed5 enrollment criteria

Bosentan Therapy in Children With Functional Single Ventricle

Congenital Heart DefectsFunctional Single Ventricle

Bosentan is a kind of dual endothelin receptor antagonist.The purpose of this study is to investigate if Bosentan therapy can modify the outcome of children with functional single ventricle.

Completed12 enrollment criteria

A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve...

Aortic Valve Disease

For this study, blood and tissue samples will be collected in order to perform genetic testing to help researchers gather information about this disease and how and why it affects some patients more than others.

Active6 enrollment criteria

The Effect of Remote Ischemic Preconditioning Applied in Children the Day Before Open Heart Surgery...

Congenital Heart Disease

The study research is to analyse brief episodes of limb ischemia applied to children the day before open heart surgery as protection from myocardial injury induced by extracorporeal circulation.

Completed9 enrollment criteria
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