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Active clinical trials for "Heart Defects, Congenital"

Results 701-710 of 806

Fontan Circulation and Cardiopulmonary Function: Prognostic Factors, Hemodynamics and Long-term...

Congenital Heart Disease

Cross-sectional study of a national cohort of adolescents with univentricular congenital heart defects and Fontan type palliation.

Completed2 enrollment criteria

Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries...

Congenital Heart DiseaseCongenital Heart Defect1 more

Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of transposition of the great arteries (TGA) and the long term reinnervation process has not been studied. We sought to describe the reinnervation status of adult patients long after the ASO, to identify areas of myocardial perfusion/innervation mismatch and to assess the relation of innervation status and exercise capacity.

Completed4 enrollment criteria

Chronic Kidney Disease in Teenagers With Congenital Cardiac Disease

Chronic Kidney FailureCongenital Heart Defects

The prevalence of chronic kidney injury (CKD) following cardiac surgery during childhood is not known, but there is evidence of CKD in young adults. In the present study assumption is made that CKD can already by diagnosed in patients at or just before adolescence, and the aim is calculate its prevalence according to the KDIGO criteria by a cross-sectional study, which will enroll patients aged 10 to 15 years. The second hypothesis is that events occurring peri-operatively during initial surgery or during follow-up could by chart review and regression analysis.

Completed6 enrollment criteria

Incidence, Risk Factors, and Risk Model of Acute Kidney Injury in Pediatric Patients Who Undergoing...

Patients Undergoing Surgery for Congenital Heart Disease

Acute kidney injury (AKI) is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. Previous studies have reported that the incidence of AKI in patients undergoing surgery for congenital heart disease is as high as 42% and AKI increase the patient mortality, intensive care unit stay and hospital stay. Previous studies have reported several risk factors for AKI after congenital heart surgery, however, perioperative variables including anesthesia-related factors have not been evaluated fully. Therefore, the investigators attempt to find out independent risk factors regarding perioperative variables.

Completed3 enrollment criteria

Colloid Osmotic Pressure During Heart Surgery in Children

Heart DefectsCongenital

Clinical oedema is seen after open heart surgery with the use of cardiopulmonary bypass and hypothermia in children. The oedema formation is due to increased fluid transport from blood to tissue. This transcapillary fluid transport is dependent on differences in interstitial and plasma colloid osmotic pressure. The purpose of this investigation is to evaluate changes in interstitial colloid osmotic pressure before, under and after the use of cardiopulmonary bypass in children. The study hypothesis is that oedema developed during cardiopulmonary bypass and hypothermia is caused by increased micro vascular protein leakage and reduced colloid osmotic pressure gradient through the capillary membrane.

Completed6 enrollment criteria

The Impact of Implementing a Universal Newborn Screening for Critical Congenital Heart Disease

Congenital Heart Disease

The purpose of this study is to evaluate the impact of implementing a universal pulse oximeter screening as a way to detect critical congenital heart disease in otherwise well-appearing newborns.

Completed9 enrollment criteria

Evaluation of Panel Reactive Antibody in Children Following Stage I Palliation for Hypoplastic Left...

Congenital Heart Disease

The purpose of this study is to determine whether children and adolescents 8-18 years of age with HLHS and related lesions who have undergone stage I palliation during infancy using an allograft patch demonstrate continued evidence of HLA antibody formation.

Completed11 enrollment criteria

Adult Congenital Heart Disease Surgery

Congenital Disorders

It is now estimated that the number of adults with congenital heart disease in the U.S is over 800,000. Unfortunately, these patients, in some way, have become a lost population. They have congenital abnormalities familiar to a children's hospital, yet have surpassed the age cutoff for admission. Recently, we have developed a specialized program to care for this unique patient population. Dedicated programs such as ours hope to optimize patient care, consolidate specialized resources, provide sufficient patient numbers for training and maintain expertise and facilitate research in this unique population.

Completed3 enrollment criteria

The Accuracy of an Artificially-intelligent Stethoscope

Heart MurmursCongenital Heart Disease1 more

This study will characterize the accuracy of a commercially available artificially-intelligent stethoscope in determining which childhood murmurs suggest underlying congenital structural heart disease and therefore warrant diagnostic echocardiograms.

Completed8 enrollment criteria

Evaluating the Infant Complex Congenital Heart Disease by Multidetector Computed Tomography

Heart Diseases

To test the ability of multi-detector spiral CT in evalting the infant complex congenital heart disease.

Unknown status2 enrollment criteria
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