
Niacin Plus Statin to Prevent Vascular Events
Cardiovascular DiseasesHeart Diseases4 moreThe purpose of this study is to determine whether raising "good cholesterol" with a drug based on the vitamin niacin, while lowering "bad cholesterol" with a statin drug, can prevent more heart disease than the statin alone.

The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic...
Heart DiseaseCardiovascular DiseaseA growing body of evidence links Chlamydia pneumoniae to the progression of coronary heart disease. The purpose of this study is to determine the positive and negative effect of 14 days treatment with clarithromycin 500 mg daily in patients already suffering from stable coronary heart disease. The participants will be followed for at least two years after the treatment. Abbott Laboratories supplied Clarithromycin and placebo tablets.

Co-administration Study in Patients With Elevated Cholesterol and Coronary Heart Disease (0653-803)...
HypercholesterolemiaCoronary DiseaseThe purpose of this study is to investigate additional cholesterol lowering effects in patients with coronary heart disease by giving an investigational drug with a patient's current approved cholesterol lowering medication.

Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery
Coronary DiseaseHeart Diseases2 moreThe purpose of this study is to examine the effects of supplemental magnesium on the neurocognitive function of individuals undergoing coronary artery bypass graft (CABG) surgery.

Optimum Platelet Inhibition After Coronary Bypass Surgery
Ischemic Heart DiseaseTo investigate the effect of different dosages of aspirin on platelet aggregation and to determine the possible mechanisms of aspirin resistance, we intend to compare the effects of low, medium dose aspirin with clopidogrel (an alternative antiplatelet agent) in patients after coronary artery bypass surgery.

A Phase II Optimization Study of BMS068645 and Sestamibi Planar Imaging
Cardiovascular DiseaseIschemic Heart DiseaseThe primary purpose of this study is to determine the optimal time for myocardial perfusion imaging with Technetium Tc99m Sestamibi following the administration of BMS068645. The safety of BMS068645 will also be studied.

Physician Uncertainty Reduction for Hypertension
Cardiovascular DiseasesHeart Diseases1 moreThe purpose of this study is to test the theory that a major factor in poor blood pressure (BP) control is that physicians fail to intensify antihypertensive therapy for their patients.

Effects of Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention
Ischemic Heart DiseaseAcute Coronary SyndromesEffects of dual antiplatelet therapy with aspirin and clopidogrel after percutaneous coronary intervention has been proven. However, patients with low response to those agents are reported be associated with adverse clinical outcomes. We suppose that optimized antiplatelet therapy for individual patients based on platelet function assay may improve long-term outcomes especially in patients with high risk of thrombosis. In this prospective randomized study, patients in control group all receive standard dual antiplatelet therapy, and patients in optimized group receive different antiplatelet therapy according to risk stratification.

Enalapril After Anthracycline Cardiotoxicity
Cardiovascular DiseasesHeart Diseases2 moreTo determine if the chronic administration of enalapril, an inhibitor of angiotensin converting enzyme (ACE), reduces progression of cardiac dysfunction in pediatric oncology patients who have received anthracyclines, and who are not currently on digoxin, diuretics, or vasodilators for heart failure.

Rapid Early Action for Coronary Treatment (REACT)
Cardiovascular DiseasesCoronary Disease3 moreTo evaluate the impact of community educational interventions on patient delay time from onset of symptoms and signs of an acute myocardial infarction (AMI) to arrival at a hospital Emergency Department (ED). Also, to study the impact of community educational interventions on use of Emergency Medical Services (EMS) and EDs, on thrombolytic therapy, and on AMI case fatality.