Free DNA and Nucleosome Concentrations in Pathological Pregnancies
PregnancyVenous Thrombosis8 moreThe primary objective of this study is to demonstrate that plasma concentrations of nucleosomes and free DNA differ between three groups: pregnant patients with complications typical of placental insufficiency or venous thrombosis (group P), healthy women (Group T1) and healthy pregnant women (Group T2).
Women Specific Cardiac Recovery After Preeclampsia
Pre-EclampsiaPregnancy2 morePregnancy is considered a cardiovascular (CV) stress test, and complicated pregnancies are associated with an increased risk for cardiovascular disease (CVD) later in life. Moreover, it is known that often the pregnancy induced CV adaptation does not resolve completely after a short postpartum (PP) period and it is not clear whether these induced changes will resolve over a longer period of time (i.e. in the upcoming months/years after delivery). Understanding the cardiac adaptation during pregnancy and the reversal process in the postpartum period, as well as the factors that influence this these processes, may provide us not only insight in this mechanism, but may help us in identifying factors that may be target points for modification.
TTP and aHUS in Complicated Pregnancies
Thrombotic Thrombocytopenic PurpuraAtypical Hemolytic Uremic Syndrome6 moreA single site observational study aiming to: (i) Identify cases of previously undiagnosed thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic syndrome (aHUS) in a cohort of women with complicated pregnancies (ii) Characterise the clinical features of these cases and (ii) Identify clinical features or biomarkers which may help distinguish TTP/aHUS from other complications of pregnancy such as preeclampsia
Pancreatic Stone Protein (PSP) in Pregnant Women
PregnancyHELLP Syndrome2 moreThis prospective, single centred cohort study evaluates the physiological course of the potentially novel biomarker PSP in pregnant women as well as its predictive role in the development of inflammatory complications during pregnancy.
Human Epididymis Protein 4 in Women With Severe Preeclampsia / HELLP Syndrome
PreeclampsiaPre-eclampsia seems to be associated with a four to five times increase risk of later microalbuminuria and CKD which might suggest a possible direct renal damage from pre-eclampsia