search

Active clinical trials for "Hematologic Neoplasms"

Results 1071-1080 of 1132

Validation of a Comprehensive Health Status Assessment Scale in Elderly Patients (≥ 65 Years) With...

Myelodysplastic SyndromesLeukemia Myeloid Acute4 more

The elderly comprise the most prevalent population in oncology practice. The available evidence suggests that old patients are undertreated patients, mainly because of their advanced age, regardless of whether they are highly functional patients, they do not present co morbidities and could benefit from oncology therapies. Treatment planning must consider several health indices that are useful when it comes to detecting geriatric problems that could affect the patient's treatment experience. The complete comprehensive geriatric evaluation stands out as cornerstone among other validated tools that do not work as isolated instruments; however, its length and complexity may hinder its routine use in clinical practice for decision making. The purpose of this study is to validate a comprehensive health status assessment scale in elderly patients (≥65 years) with hematological malignancies that, while integrating the essential dimensions of geriatric assessment and, with the same precision as the currently available valid tools, is shorter and easier to apply, so it can be incorporated into the daily practice and that aids in clinical decision making objectively. If so, this information would help identify patients that could benefit from a specific oncology treatment, thus contributing to developing a targeted intervention plan and to optimizing the cancer results in this patient population.

Completed4 enrollment criteria

Diagnosing Pulmonary Aspergillosis in Patients With Hematological Malignancies: A Multicentre Prospective...

Invasive Aspergillosis

Diagnosing invasive pulmonary aspergillosis (IPA) remains a challenge in patients (pts) with hematological malignancies. The clinical significance of testing bronchoalveolar lavage (BAL) samples both with polymerase chain reaction (PCR) and Aspergillus galactomannan (GM) ELISA is unclear, and the BAL cutoff for GM has not been clearly defined yet. Using a validated nested PCR assay and a GM ELISA, we prospectively examine BAL samples from hematological patients at high risk of PA.

Completed2 enrollment criteria

Cell Selection for Bone Marrow Transplants to Prevent Graft-Versus-Host-Disease

Graft vs Host DiseaseHematologic Neoplasm

Blood contains different kinds of cells, white blood cells, red blood cells, and platelets. In order to treat certain diseases, specific cell types can be removed from blood and transplanted into patients. The process of removing white blood cells for the treatment of leukemia is called apheresis. This study will make available blood cell collections from volunteers genetically matched to various degrees with recipients in order to test and, if necessary, refine the process of removing white blood cell T-lymphocytes....

Completed10 enrollment criteria

Prognosis of Hematological Cancer Patient Underwent Mechanical Ventillation

Hematological MalignancyAcute Respiratory Failure1 more

This observational cohort aimed to re-evaluate the outcome of hematologic cancer patients admitted to the intensive care unit of Mansoura oncology center through a cohort study as regards their need for mechanical ventilation during two years.

Completed4 enrollment criteria

Systematic and Mechanism-based Approach to Rational Treatment Trials of Blood Cancer

Hematologic DiseasesTreatment

This observational study evaluates if drug response testing can be performed within 7 days and analyzes the value of ex-vivo drug screening for hematological malignancies as a biomarker to predict outcome, clinical course and response to treatment.

Completed10 enrollment criteria

The Oronasal Microbiota in Pediatric Oncology Patients

Acute Myeloid LeukemiaHematologic Malignancy1 more

The human microbiome is composed of unique groups of microorganisms occupying distinct habitats distributed throughout the human body. The Human Microbiome Project recently evaluated the bacterial composition of the microbiome in 18 (for women) and 15 (for men) body sites. Much initial attention in the field of microbiome research has focused on the bacterial contribution to a "healthy" microbiome. However, it is clear that other microorganisms, including fungi and viruses, are also distributed throughout the human body and serve as functional components of the microbiome. The populations of microorganisms residing within the oral and nasal cavities make important contributions to human health and disease. These contributions may be especially important in immunosuppressed patients, including those patients receiving myelosuppressive chemotherapy or undergoing hematopoietic stem cell transplantation. In these patients, organisms typically considered as commensals can become pathogenic, either locally or systemically. This observational study is primarily undertaken to evaluate the oral and nasal microbiota and to define the population of fungal organisms residing within the oral and nasal cavities in pediatric oncology patients before and after receiving protocol-directed chemotherapy and associated supportive care.

Completed7 enrollment criteria

Impact of COVID-19 After Autologous Hematopoietic Stem Cell Transplantation in Sweden

Covid19Myeloma Multiple3 more

This retrospective observational cohort study aims to describe the impact of COVID-19 in patients treated with autologous stem cell transplantation (ASCT) for malignant disease in terms of risk factors, morbidity, need for supportive care and mortality. All patients treated with ASCT in Sweden from 1st January 2020 until 31st December 2020 are eligible for this study. Patients who also has tested positive for SARS-CoV-2 from start of conditioning or later will be identified through the national registry of the Public Health Agency of Sweden and a systematic analysis of their medical records will be performed.

Completed4 enrollment criteria

Screening for Colonization With Resistant Enterobacterales in Neutropenic Patients With Hematologic...

Hematologic MalignancyLeukemia3 more

This is a prospective, observational cohort study to assess the frequency with which neutropenic patients with hematologic malignancies and hematopoietic cell transplant (HCT) recipients are colonized with fluoroquinolone-resistant Enterobacterales (FQRE) and the clinical impact of FQRE colonization.

Completed10 enrollment criteria

The Use of Intensive Care in Critically Ill Cancer Haematological Patients: "TRIAL-OH"

Hematological Malignancies

The purpose of this study is to determine: Condition of intensive care unit (ICU) admission in patients with haematological malignancies. ICU hospital and up to one year mortality. Assessment of post ICU burden and health related quality at 90-d and 1 year.

Completed4 enrollment criteria

AVN of Weight-Bearing Joints In Patients With Hematologic Malignancies Treated With Dexamethasone...

Avascular NecrosisAcute Lymphoblastic Leukemia

The primary purpose of this study is to compare the incidence of AVN in children with hematologic malignancies treated with prednisone versus dexamethasone during continuation.

Completed3 enrollment criteria
1...107108109...114

Need Help? Contact our team!


We'll reach out to this number within 24 hrs