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Active clinical trials for "Hematologic Diseases"

Results 321-330 of 364

Identification and Analysis of Immunomodulatory Molecules in Patients With Hematologic Disorders...

Hematologic DiseasesHealthy Volunteers

This research study goal is to analyze the plasma and the cells that make up part of the immune system. We want to learn how the plasma and cells work. These may influence why one person will develop an infection and another will not, or why one person develops severe symptoms of a disease while others remain without symptoms.

Completed5 enrollment criteria

National Health and Nutrition Examination Survey IV (NHANES (IV)

Cardiovascular DiseasesCoronary Disease4 more

To supplement the fourth National Health and Nutrition Examination Survey protocol to include data on the common heart, vascular, lung, and blood diseases.

Completed1 enrollment criteria

Systematic and Mechanism-based Approach to Rational Treatment Trials of Blood Cancer

Hematologic DiseasesTreatment

This observational study evaluates if drug response testing can be performed within 7 days and analyzes the value of ex-vivo drug screening for hematological malignancies as a biomarker to predict outcome, clinical course and response to treatment.

Completed10 enrollment criteria

Using DNA-Typing and Erythrocyte Microparticle Analysis to Detect Blood Doping

Blood DiseaseBlood Transfusion4 more

A total of 12 subjects will be recruited for participation in this study. 6 subjects will receive re-infusion of autologous blood, and 6 subjects (anemic patients) will receive a homologous transfusion.

Unknown status7 enrollment criteria

French One Day Survey in 2011 - Knowing Our Population of Labile Blood Products Recipients

Blood Product Transfusion for All ConditionsTrauma2 more

Describe the epidemiologic profile and clinical context of transfusion recipients in France. Describe the clinical context of transfusion. Describe the characteristics of the transfusion prescriptions, the use of blood products and the main indications for transfusion. Describe transfusion practice according the type of hospital stay.

Completed2 enrollment criteria

Frequency of COVID-19 Antibodies in Patients With Hereditary Hematological Diseases

Thalassemia MajorCovid19

In Italy there are about 5000 patients with dependent transfusion thalassemia (source Italian Thalassemia and Hemoglobinopathies - SITE) and a smaller number, currently not definable, of patients with sickle cell anemia in chronic transfusion. A recent study in the Lombardy region identified the positivity of anti-Covid-19 antibodies in 4.5-7% of asymptomatic donors (Valenti L et al). As already known, a preliminary study conducted in Italy (Motta I et al, Hussain FA et al, Taher A et al) reported only 11 cases of symptomatic infection all with benign evolution. Currently there are 15 reported cases (12 thalassemias and 3 sickle cell anemias). 75% of the cases have been identified in Lombardy. Our hypothesis is that in a percentage of polytransfused patients a transmission of the virus may have developed that stimulated the production of protective antibodies. This could be an explanation of the low contagiousness and severity of the infection in polytransfused patients. Currently no data are available for this purpose. This study will be conducted in collaboration with the Microbiology Unit and involves the determination of SARS-CoV-2 antibodies (anti-s1 and s2) by CLIA method with a high sensitivity (94.7%) and specificity (98.5%).

Completed3 enrollment criteria

AAV Gene Therapy Screening/Observational Protocol (ECLIPSE)

Hemophilia BBlood Coagulation Disorders3 more

Freeline is developing adeno-associated virus (AAV) vector based gene therapies for a number of diseases and is actively advancing a programme in Haemophilia B (HB). This study aims to collect prospective data to characterise bleeding events and Factor IX (FIX) concentrate consumption in HB patients that can be used as baseline for participants who elect to participate in a subsequent Freeline gene therapy study. The study will also screen participants for antibodies to a novel AAV vector to assess their suitability for inclusion in a Freeline gene therapy treatment study.

Completed20 enrollment criteria

Evaluation of the Reasons and Consequences of Bleeding in Late Teens and Early Adulthood Patients...

Hematologic DiseaseBlood Coagulation Disorders

Understanding how often the bleeding events occur in the subjects who voluntarily decide to switch from prophylaxis to on-demand and in those subjects who remain on prophylaxis. Also look into the consequences of switching treatment in QoL (quality of life), development of target joints, activity level and reasons that might influence the desire to switch.

Completed8 enrollment criteria

Vietnam Era Twin (VET) Registry

Cardiovascular DiseasesBlood Disease2 more

To conduct a baseline survey on cardiovascular, respiratory, and other major systemic disease and risk factors in members of the Vietnam Era Twin Registry.

Completed1 enrollment criteria

Drug Etiology of Aplastic Anemia and Related Dyscrasias

Blood DiseaseAnemia4 more

To determine the role of drugs in the etiology of aplastic anemia, agranulocytosis, and thrombocytopenic purpura. Drugs used in chemotherapy and immunotherapy were excluded.

Completed0 enrollment criteria
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