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Active clinical trials for "Myelodysplastic Syndromes"

Results 1961-1970 of 2004

Investigation of the Cylex® ImmuKnow® Assay

LeukemiaNon-Hodgkin's Lymphoma7 more

Currently, there is no accurate way of predicting the occurrence of Graft vs Host Disease (GvHD) or infection. The purpose of this study is to analyze blood with the ImmuKnow® Assay to see if doctors can detect which patients are at risk for GvHD and for getting an infection before they occur.

Completed10 enrollment criteria

AVIDA The Vidaza® (Azacitidine) Patient Registry

Myelodysplastic Syndromes

This registry is a prospective, multi-center, observational study compiling data on the natural history and management of patients receiving Vidaza, and will provide unique insights into the management of myelodysplastic syndromes (MDS) and other hematological disorders and the impact of these disorders on patients.

Completed8 enrollment criteria

Mutational Analysis as a Prognostic and Predictive Marker of Cardiovascular (CVD) Disease in Patients...

MDSCardiovascular Diseases1 more

This study evaluates the relationship between myelodysplastic syndromes (MDS) and cardiovascular disease. MDS patients will be evaluated for the presence of mutations and whether they are associated with an increased risk of heart disease (CVD) and inflammation compared to healthy adults. Patients without symptoms of CVD will receive CT scans to assess for hidden disease and if that is related to their mutations.

Unknown status7 enrollment criteria

Observational Study of Iron Overload in Stem Cell Transplantation

Acute Myeloid LeukemiaAcute Lymphoblastic Leukemia1 more

Recent retrospective studies have suggested that iron overload is a clinically important problem in patients undergoing ablative stem cell transplantation. However, these studies relied on serum ferritin as a surrogate of iron overload, which limits the conclusions that can be drawn from such analyses. Therefore, the investigators are conducting a prospective study to more rigorously examine the prevalence, mechanisms, and consequences of iron overload in this patient population.

Completed9 enrollment criteria

Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders

CMLALL4 more

This study performs HLA matched stem cell transplantation from unrelated donors in adults who require stem cell transplantation but do not have a matched related donor available. The incidence of graft-versus-host disease in unrelated stem cell transplantation is recorded. This study also monitors the activity and toxicity of total body irradiation and cyclosphosphamide followed by stem cell transplantation from matched unrelated donors.

Completed11 enrollment criteria

Multicenter Observational Study on Myocardial Iron Overload in 3 Multitransfused Populations

ThalassemiaSickle Cell Disease1 more

The investigators' primary objective is to study prevalences of myocardial iron overload, defined as a cardiac T2*< 20 ms, in 3 populations of multiply transfused patients, affected with thalassemia, sickle cell disease, and myelodysplasia.

Completed4 enrollment criteria

Occupational Status and Hematological Disease

Chronic Myeloid LeukemiaChronic Lymphocytic Leukemia3 more

Diseases do not only have a physical role in people's live, but they usually involve changes in life as whole. They may modify the structure of the conjunction with life setting, thus, deeply impacting relationships with others. While clinical results of new therapies for hematological diseases are well documented in scientific literature in terms of prolonged life expectancy or remission from disease, less is known about problems and barriers preventing the return of patients with a chronic blood ailment to everyday life. Indeed, there are no published data on this topic within the Italian context. The present explorative study aims at identifying the main problems with which patients affected by a Chronic Hematological Disease (CHD) deal when returning to everyday working life, factors associated with work reintegration and, finally, to understand the need for facilitators enhancing reintegration outcomes. Results from this study will be also helpful to raise consciousness about the problem of reintegration into the labour market of workers with CHD and to call for awareness campaigns for the general public and health professionals.

Completed4 enrollment criteria

Identification of Mechanism in the Erythroid Response in Patients With Myelodysplasia Undergoing...

MyelodysplasiaMyelofibrosis1 more

The study aims to evaluate the molecular mechanism underlying the erythroid response observed in some patients with myelodysplasia, myelofibrosis and aplastic anemia treated with Deferasirox or Deferoxamina.

Completed4 enrollment criteria

Transplant-Related Mortality in Patients Undergoing a Peripheral Blood Stem Cell Transplantation...

Acute Myeloid LeukemiaAcute Lymphoblastic Leukemia1 more

Study CR-AIR-006 is a part of the ATIR clinical development plan and will provide control data for patients treated with ATIR in clinical studies (e.g. study CR-AIR-007).

Completed10 enrollment criteria

MDS-CAN: A Prospective National MDS Clinical Database and Local Tissue Bank

Myelodysplastic Syndrome (MDS)

The purposes of this study are: 1. To identify and quantify the health utilities and quality of life experienced by patients who have been diagnosed with MDS and what are their predictors. 2. Measure the effects of patient related factors like frailty and comorbidity on quality of life and overall survival or toxicity to therapy. 3. Assess how quality of life changes over time and what are its predictors. This will be valuable information that may guide therapy, transfusion practices, etc., as MDS is a chronic, incurable disease that is often progressive.

Unknown status9 enrollment criteria
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