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Active clinical trials for "Hematologic Neoplasms"

Results 371-380 of 1132

Financial Difficulty in Patients With Blood Cancer

Chronic Lymphocytic LeukemiaMultiple Myeloma

This is a hypothesis-driven, observational, cross-sectional, multi-site study of the financial difficulties experienced by patients undergoing treatment for multiple myeloma (MM) and chronic lymphocytic leukemia (CLL). It is composed of a patient survey (n=250) (Appendix A), a physician survey (n=100) (Appendix B), and a practice survey completed by each site enrolling patients onto this study (Appendix C). A subset of enrolled patients (n=35) will be invited to participate in an optional second telephone interview (Appendix D). This study will measure the prevalence of patient-reported financial difficulty, specific financial burdens and resources currently available to patients and from practices to assist with patient financial navigation.

Recruiting17 enrollment criteria

Protocol For Genomically Profiling, Collecting, Archiving And Distributing Blood And Bone Marrow...

LeukemiaMyelodysplastic Syndromes1 more

This research study is a genomic profiling and repository study for children and young adults who have leukemia, myelodysplastic syndrome (MDS) or myeloproliferative syndrome (MPS). Genes are the part of cells that contain the instructions which tell cells how to make the right proteins to grow and work. Genes are composed of DNA letters that spell out these instructions. Genomic profiling helps investigators understand why the disease develops and the instructions that led to its development. Understanding the genetic factors of the disease can also help investigator understand why the disease of some people can respond to certain therapies differently than others. The genomic profiling will be performed using bone marrow and blood samples that either have already been obtained during a previous clinical procedure or will be obtained at the time of a scheduled clinical procedure. Studying the genetic information in the cells of these samples will provide information about the origin, progression, and treatment of leukemia and myeloproliferative syndromes and myelodysplastic syndrome. Storing the bone marrow and blood samples will allow for additional research and genomic assessments to be performed in the future.

Recruiting8 enrollment criteria

The Leukemia and Lymphoma Society (LLS) National Research Registry

Blood Cancer

The Leukemia and Lymphoma Society (LLS) has built a National Research Registry to evaluate real world experiences and medical outcomes for people with blood cancer, before, during, and after blood cancer treatments.

Recruiting2 enrollment criteria

Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular...

CancerHematopoietic System--Cancer6 more

This study is being done because the investigators would like to learn more about how well the COVID-19 vaccine works in participants with cancer or those who have received a transplant or cellular therapy. Primary Objective Assess the immunogenicity to COVID-19 vaccination in patients with cancer and/or transplant and cellular therapy (TCT) recipients. Secondary Objectives Evaluate the antibodies response to COVID-19 vaccination in immunocompromised patients. Evaluate the T cell response to COVID-19 vaccination in immunocompromised patients. Exploratory Objectives Assess incidence and severity of COVID-19 infections by 6 months following immunization with a SARS CoV-2 vaccine. Assess the durability immune response to COVID-19 vaccination. Assess the immunogenicity of COVID-19 vaccination in immunocompetent children and adolescents without cancer and have not undergone transplant or received cellular therapy.

Recruiting11 enrollment criteria

COVID19-hematological Malignancies: the Italian Hematology Alliance

SARS-CoV-2 InfectionHematological Malignancies

This is a retrospective/prospective, cohort, non-interventional observational study. This means that all patients with documented COVID and HM diagnosed between February 2020 and study initiation will compose the retrospective part, while those diagnosed after study approval will enter prospective part. The total duration of the study will be 12 months. The study population will must be older than 18 years of age with HM and SARS-CoV-2 infection. All patients with documented SARS-CoV-2 infection (COVID) and history or active hematological malignancies, who refer to any Hematological Unit will be included.

Recruiting6 enrollment criteria

Evaluation of ClearLLab LS Screening Panel

Hematologic MalignancyHematologic Neoplasms1 more

This is a multi-center study to evaluate the clinical performance of ClearLLab LS screening panel with specimens from subjects for the diagnosis of hematologic malignancies.

Recruiting7 enrollment criteria

The Association of Microbiota Composition With cGVHD After Allo-HSCT

Hematopoietic Stem Cell TransplantationHematologic Malignancy2 more

Previous studies had found that the microbe in intestinal after allogeneic hematopoietic cell transplantation(allo-HSCT) were closely associated with overall survival and post-transplantation complications, especially graft versus host disease (GVHD).Due to the limited data on the association of microbiota composition with chronic GVHD(cGVHD) after allogeneic hematopoietic stem cell transplantation, the relationship between microbiota composition and post-transplantation complications, especially cGVHD, needs to be further evaluated.Detailed studies of the microbiome and host immune system will lead to the discovery of microbiome markers for early identification of patients at high risk for cGVHD. This may regulate patients' gut microbiota in an individualized manner to achieve optimal treatment outcomes while avoiding severe post-transplant cGVHD. We will operate a prospective, multicenter, nonrandomized, observational study. Patients will be asked to provide blood and stool samples during allo-HSCT.

Recruiting4 enrollment criteria

Prevalence of FID and QoL in Patients With Oncological and With Haematological Malignancies

Functional Iron Deficiency

Prospective single-center observational study assessing prevalence of FID (Laboratory work-up) and Quality of Life (Questionnaire) in adult patients with oncological and with haematological malignancies within four weeks prior to disease-directed therapy.

Recruiting11 enrollment criteria

Mechanisms of Disease R/R in CAR-T for Hematologic Malignancies

Hematologic Malignancy

The primary purpose of this IRB protocol is to perform immune profiling focusing on the measurement of Myeloid derived suppressor cells (MDSCs) over time in patients receiving Chimeric antigen receptor (CAR) T therapy and determine the correlation between immune profile and disease relapse/resistance in CAR T therapy.

Recruiting4 enrollment criteria

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

Cancer RiskCancer Predisposition Syndrome30 more

This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of progression to symptomatic cancer that can ultimately be fatal. The ultimate goal is to identify novel markers of early detection and risk stratification to drive potential therapeutic approaches to intercept progression to cancer.

Recruiting27 enrollment criteria
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