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Active clinical trials for "Hematologic Neoplasms"

Results 691-700 of 1132

Safety Assessment of Two Schedules of Intravenous Infusions of SNS-595 for the Treatment of Hematologic...

LeukemiaLymphocytic8 more

This study primarily determined the safety and tolerability of escalating doses of vosaroxin (SNS-595) in 2 dose schedules, and assessed the PK profile of vosaroxin and defined a recommended dose regimen for Phase 2 studies. Secondarily the study assessed potential biomarkers and antileukemic activity.

Completed20 enrollment criteria

A Phase I/II Study of Mis-Matched Immune Cells (AlloStim) in Patients With Advanced Hematological...

Hematological MalignancyLeukemia2 more

The purpose of this study is to determine the safety and anti-tumor effects of an experimental immunotherapy drug, called AlloStim, which is intentionally mis-matched immune cells which are designed to elicit the same anti-tumor mechanism that occurs in allogeneic bone marrow/stem cell mini-transplant (BMT) procedures, without the toxicity associated with graft vs. host disease (GVHD).

Completed6 enrollment criteria

Phase I/II Trial of Fludarabine Plus Busulfan and Allogeneic Progenitor Cell Support

Hematologic Malignancies

Objectives: To determine the relative toxicities, engraftment potential, kinetics of engraftment, degree of chimerism and disease control achieved with the combination of fludarabine and busulfan at different dose levels and different dose schedules in patients undergoing allogeneic stem cell transplant (SCT). Determine pharmacokinetics, and toxicity of intravenous busulfan given at equal total dose levels given four times daily, or once daily. In vivo determination of fludarabine inhibitory effects on DNA repair.

Completed11 enrollment criteria

Phase I-II Study to Determine the Maximum Tolerated Dose (MTD) of AUY922 in Advanced Solid Malignancies,...

Breast CancerHematologic Neoplasms

This is a phase I/II, open-label, multicenter study of AUY922 administered intravenously in patients with advanced solid malignancies to determine the maximum tolerated dose. Phase II expansion arms will investigate efficacy in patients with either HER2 positive or ER positive locally advanced or metastatic breast cancer. Additional patients with advanced solid malignancies will also be investigated in a separate expansion arm. Safety, pharmacokinetics and pharmacodynamics will be assessed.

Completed42 enrollment criteria

Cloretazine (VNP40101M) With Hematopoietic Cell Transplantation for Hematologic Malignancies

Hematologic Malignancies

Primary: Define the maximal tolerated dose (MTD) of VNP40401M when given with hematopoietic cell transplantation (HCT) Secondary: Describe the change in pharmacokinetic (PK) parameters with increasing doses of drug. Describe and estimate the frequency of > Grade 3 non-hematologic/non-infectious toxicities at the MTD. Report the efficacy of the regimen. Evaluate the rate of engraftment for the regimen.

Completed15 enrollment criteria

STA-5312 Administered on Alternate Weekdays Every Two Weeks to Patients With Hematologic Malignancies...

Hematological MalignanciesLeukemia2 more

The purpose of this study is to determine the safety, toxicity and patient tolerance of STA-5312 administered intravenously to patients with relapsed or refractory hematological malignancies and patients with solid tumors.

Completed31 enrollment criteria

T-Cell-Depleted Allogeneic Stem Cell Transplantation After Immunoablative Induction Chemotherapy...

Chronic Myeloproliferative DisordersLeukemia4 more

RATIONALE: Donor peripheral stem cell transplantation may be able to replace bone marrow and immune cells that were destroyed by chemotherapy. Sometimes the transplanted cells from a donor are rejected by the body's normal cells. Eliminating the T cells from the donor cells before transplanting them and giving cyclosporine may prevent this from happening. PURPOSE: This phase I trial is studying the side effects of T-cell-depleted allogeneic stem cell transplantation after immunoablative induction chemotherapy and reduced-intensity transplantation conditioning (chemotherapy) in treating patients with hematologic malignancies.

Completed114 enrollment criteria

Phase II Study of ZIO-101 in Advanced Blood and Bone Marrow Cancers

Hematologic NeoplasmsBone Marrow Neoplasms1 more

The study of safety of a new organic arsenic compound in the treatment of hematological malignancies.

Completed20 enrollment criteria

Pegfilgrastim Versus Filgrastim After High-dose Chemotherapy

Hematological NeoplasmsTumors

The primary objective of the study is to evaluate the efficacy and the safety of pegfilgrastim versus filgrastim, administered after high-dose chemotherapy and peripheral stem cell reinfusion.

Completed5 enrollment criteria

Tacrolimus, Sirolimus and Methotrexate as Graft Versus Host Disease Prophylaxis After Blood Stem...

Graft Versus Host DiseaseHematologic Malignancies

The purpose of this study is to determine if the incidence of Graft vs. Host Disease (GVHD) after non-myeloablative transplantation can be reduced by using a combination of three immune suppressive medication; sirolimus, tacrolimus and methotrexate.

Completed12 enrollment criteria
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