
Misoprostol for Treatment of Postpartum Haemorrhage (PPH) in Home Births
Postpartum Hemorrhage (PPH)Misoprostol, a prostaglandin E1 that induces uterine contractions, has been proposed as a low cost, easy-to-use option for prevention and treatment of Postpartum Haemorrhage (PPH), especially in settings where injectable uterotonics are not yet available or feasible to use. A double-blinded individual randomized controlled study of misoprostol versus placebo in home deliveries in four districts in the Badakshan Province in Afghanistan. The study will recruit pregnant women who are likely to deliver at home. All women enrolled in the study will receive 600 mcg misoprostol to be self-administered as prophylaxis for PPH after delivery of their baby (ies) and before delivery of the placenta. Women who experience a PPH will be randomized to receive either: a) standard of care + 800 mcg misoprostol (four 200 mcg tablets) or b) standard of care + four placebo tablets resembling misoprostol. In this setting, standard of care is referral.

Safety and Preliminary Efficacy of Activated Recombinant Human Factor VII for Preventing Early Hematoma...
Acquired Bleeding DisorderIntracerebral HaemorrhageThis trial is conducted in the United States of America (USA). The aim of this trial is to evaluate the safety and preliminary efficacy of activated recombinant human factor VII (NovoSeven®) for preventing early hematoma growth in acute Intracerebral Hemorrhage (ICH).

Safety and Efficacy of Activated Recombinant Human Factor VII in Patients Undergoing Orthotopic...
Acquired Bleeding DisorderBleeding During/Following SurgeryThis trial is conducted in Europe, North America and Oceania. The aim of this trial is to evaluate the haemostatic efficacy of activated recombinant human factor VII in subjects undergoing orthotopic liver transplantation surgery.

Short Course Terlipressin for Control of Acute Variceal Bleeding
HemorrhageEsophageal Varices1 moreThe purpose of this study is to determine whether 24 hours of Terlipressin is as effective as 72 hours of Terlipressin in preventing re-bleed once esophageal variceal bleed has been controlled with endoscopic therapy (variceal band ligation or sclerotherapy) in low to moderate risk variceal bleed patients and hence can save cost and may decrease length of hospital stay especially in the I.C.U or high dependency units.

Factor VIIa in Acute Intracerebral Haemorrhage
Acquired Bleeding DisorderIntracerebral HaemorrhageThis trial is conducted in Japan. The purpose of this trial is to evaluate the safety and preliminary efficacy of Activated Recombinant Factor VII (NN-007) in patients with acute intracerebral haemorrhage.

Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage
Vitreous HemorrhageDiabetic RetinopathyThe purpose of this study is to determine if intravitreal injection of Vitrase (ovine hyaluronidase) clears vitreous hemorrhage

Treatment of Non-Gestational Acute Uterine Bleeding: A Randomized Trial
Uterine HemorrhageMenorrhagiaTo determine the relative efficacy of multidose medroxyprogesterone acetate (MPA, Provera) and a multidose, monophasic combination oral contraceptive in the treatment of hemodynamically stable women with non-gestational, acute uterine bleeding.

Effect of Rosuvastatin in Intracerebral Hemorrhage
Intracerebral HemorrhageStrokeThe purpose of this study is to determine whether rosuvastatin is effective in the management of acute phase of intracerebral hemorrhage and if it impact outcome by NIHSS.

N-Butyl-2-Cyanoacrylate Injection Versus Band Ligation for Gastric Variceal Hemorrhage
Gastric Variceal HemorrhageThe purpose of this study was to test the hypothesis by comparing the efficacy of cyanoacrylate injection (GVO) and band ligation (GVL) in the treatment of acute GVH in liver cirrhotic patients with or without concomitant hepatocellular carcinoma (HCC).

Efficacy and Safety Study for the Treatment of Dysfunctional Uterine Bleeding
MetrorrhagiaThe purpose of this study is to determine whether the study drug is safe and effective in the treatment of dysfunctional uterine bleeding.