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Active clinical trials for "Hemostatic Disorders"

Results 381-390 of 450

Observational Study on the Use of NovoSeven® for Haemostatic Treatment of Bleeding Episodes in Patients...

Acquired Bleeding DisorderAcquired Haemophilia

This study is conducted in Europe. The aim of this prospective, observational study are to describe the different clinical practice and detailed haemostatic management of activated recombinant human factor VII (NovoSeven®) in patients with acquired haemophilia in France. The secondary aim is to assess the primary haemostasis disorder associated with the coagulation disorders, if available.

Completed5 enrollment criteria

Evaluation of the Reasons and Consequences of Bleeding in Late Teens and Early Adulthood Patients...

Hematologic DiseaseBlood Coagulation Disorders

Understanding how often the bleeding events occur in the subjects who voluntarily decide to switch from prophylaxis to on-demand and in those subjects who remain on prophylaxis. Also look into the consequences of switching treatment in QoL (quality of life), development of target joints, activity level and reasons that might influence the desire to switch.

Completed8 enrollment criteria

Modified Ultrafiltration in Cardiac Surgery

CoagulopathyRethoracotomy2 more

The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.

Completed2 enrollment criteria

Assessment of Bleeding Symptoms in Normal Individuals Using a Comprehensive History Phenotyping...

Bleeding Disorder

A wide variety of individuals are at risk for bleeding, but even though bleeding symptoms are common it is difficult to compare different people's symptoms. Recent research has found that carefully designed surveys can be used to calculate a bleeding score that is useful for diagnosing bleeding disorders, but normal individuals have not been specifically studied in large numbers with a comprehensive survey. Whether factors like race, ethnicity, age, sex, aspirin use, and previous trauma and surgery influence bleeding scores is also unknown. The primary goal of this study is to use a comprehensive computerized questionnaire to record the bleeding symptoms of normal individuals and then assess the range and severity of bleeding symptoms in this normal population. Secondary goals include determining whether race, ethnicity, age, sex, aspirin use, and previous trauma and surgery correlate with bleeding symptoms.

Completed7 enrollment criteria

Goal-orientated Therapy of Perioperative Disturbance in Hemostasis in Cardiac Surgery

Coronary Artery Bypass Graft Triple VesselBlood Coagulation Disorders

Aim of this study is to investigate whether patients preoperatively treated with acetylsalicylic acid and/or clopidogrel have fewer perioperative bleeding and lower amounts of blood substitution when managed by ROTEM (whole blood coagulation analyzer) and MULTIPLATE (thrombocyte function analyzer).

Completed2 enrollment criteria

Coagulation Changes Associated With COVID-19 Infection

COVIDDisseminated Intravascular Coagulation1 more

This study will study the potential utility of the Quantra QPlus System in patients inflicted with COVID-19 disease.

Completed9 enrollment criteria

Bleeding in Hospitalized Patients With Liver Disease Undergoing Invasive Procedures

BleedingProcedural Complication4 more

Patients with cirrhosis are frequently hospitalized and often undergo procedures. Knowledge surrounding bleeding risk is sparse and practice patterns vary across centers in regards to bleeding prophylaxis. The goal of this study to is to obtain more knowledge regarding risk factors for procedural related bleeding in patients with cirrhosis and to develop a predictive model to risk stratify patients before undergoing procedures. Through collaboration from centers across the world this study should provide information on prevalence of bleeding and variation in practice patterns for prophylaxis.

Completed7 enrollment criteria

Blood Gas and Bleeding Disorders in Healthy Volunteers Exposed to Nitroglycerin and Nitrogen Compounds...

Disorder of Blood GasBleeding Disorder

The aim of the study was to investigate the possible relationship about blood gas and bleeding disorders in healthy volunteers of blasters and no blasters groups of the Italian National Mountain and Cave Rescue who handled nitrogen compounds and nitroglycerine and then they were exposed to combustion products from an accidental uncontrolled detonation of micro-charges during a cave unblocking procedure.

Completed4 enrollment criteria

Inflammatory Bowel Disease and Thromboembolic Events

Inflammatory Bowel DiseasesThromboembolism1 more

The main objective was to demonstrate the existence and importance of hypercoagulability in patients with IBD, by determining the prevalence of changes in coagulation parameters and evaluating the impact of these changes on the occurrence of thromboembolic events.

Completed2 enrollment criteria

Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical Infections...

Disseminated Intravascular CoagulationCritical Illness5 more

Inflammation and abnormalities in laboratory coagulation tests are inseparably tied. For example, coagulation abnormalities are nearly universal in septic patients. Coagulation disorders have also been reported in many patients with severe courses of Coronavirus disease 2019 (Covid-19). But it is difficult to assess these changes. Global coagulation tests have been shown to incorrectly assess in vivo coagulation in patients admitted to intensive care units. But other tests are available. Thrombin generation assay (TGA) is a laboratory test which allows the assessment of an individual's potential to generate thrombin. But also in conventional TGA the protein C system is hardly activated because of the absence of endothelial cells (containing natural thrombomodulin) in the plasma sample. Therefore the investigators add recombinant human thrombomodulin to a conventional TGA. Thereby the investigators hope to be able to depict in vivo coagulation more closely than global coagulation tests do.

Completed13 enrollment criteria
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