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Active clinical trials for "Liver Cirrhosis"

Results 291-300 of 1394

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications...

Liver DiseasesLiver Cirrhosis2 more

Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-threatening complications in the donor.

Recruiting8 enrollment criteria

Integrated Diagnostics for Early Diagnosis of Liver Disease

Non-Alcoholic Fatty Liver DiseaseNon-alcoholic Steatohepatitis2 more

This is an observational study that will explore the hypothesis that by combining data from patients with liver disease with novel blood biomarkers, single nucleotide polymorphism (SNP) analysis and faecal microbiome analysis. The Investigators will improve diagnosis of liver fibrosis compared to the current available diagnostic tools.

Recruiting9 enrollment criteria

Characterization and Pathogenesis of ACLF

Liver CirrhosisAcute-On-Chronic Liver Failure1 more

This single-center prospective observational study aims at characterization of pathogenesis of ACLF. There will be three different cohorts investigated with the main endpoint mortality in these groups. SAPIENT = Sepsis ACLF patients, to investigate the differences between ACLF and sepsis in cirrhosis PROACT = Portal mediators as ACLF Targets, to assess portal venous biomarkers in patients receiving TIPS leading to ACLF and identify potential treatment targets ELITE = prEdictors of beneficial LIver Tx in ACFL patiEnts, to assess in ACLF-patients receiving liver transplantation predictors of survival, which may improve selection of ACLF-patients for liver transplantation Secondary endpoints will be different in the three different cohorts and biological material will be collected for separate ancillary studies.

Recruiting4 enrollment criteria

Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1...

Nonalcoholic Fatty LiverNonalcoholic Steatohepatitis2 more

This pilot study will evaluate conventional and investigational MR imaging and spectroscopic sequences and collect data to help plan more definitive future studies.

Recruiting9 enrollment criteria

Cirrhosis Registry of Hospitalized Patients

CirrhosisLiver4 more

Cirrhosis registry of consecutive adult consenting patients hospitalized with liver cirrhosis in the tertiary liver unit

Recruiting4 enrollment criteria

Cirrhotic Cardiomyopathy Based on Point-of-care Echocardiography, Biomarkers and Histology

Cirrhotic CardiomyopathyCirrhosis2 more

Cirrhotic cardiomyopathy is associated with increased risk of complications like hepatorenal syndrome, refractory ascites, impaired response to stressors including sepsis, bleeding or transplantation, poor health related quality of life and increased morbidity and mortality. Left ventricular diastolic dysfunction (LVDD) is associated with risk of hepatorenal syndrome (HRS) , septic shock. , heart failure in the perioperative period following liver transplantation, and after trans-jugular intrahepatic portosystemic shunt (TIPS) insertion . The echocardiographic E/e' ratio is a predictor of survival in LVDD, with multiple studies, including prospective data from our Centre.

Recruiting11 enrollment criteria

ALTA TIPS: A 5-year Longitudinal Observational Study of Patients Undergoing TIPS Placement

CirrhosisLiver1 more

ALTA is a multicenter consortium focused on the management of portal hypertension. ALTA TIPS is a longitudinal observational study of patients who are undergoing transjugular intrahepatic portosystemic shunt (TIPS) placement. ALTA will create a database that will provide clinical parameters and outcomes of patients undergoing TIPS as part of their standard of care in hopes of answering key clinical questions.

Recruiting6 enrollment criteria

TIPS in Patients With Decompensated Liver Cirrhosis

Decompensated Liver Cirrhosis

This is a single center patient registry of patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) at Hannover Medical School. By collecting and analyzing clinical data as well as blood samples, the overall aim is to optimize TIPS therapy (e.g. specify selection criteria).

Recruiting8 enrollment criteria

Predictive Models of Hepatic Decompensation and Survival Outcomes in Pediatric Patients With Cirrhosis...

CirrhosisBiliary Atresia5 more

The aim of this study was to developed and validated models to predict hepatic decompensation and survivals in pediatric patients with cirrhosis and compared these models with currently available models.

Recruiting5 enrollment criteria

Natural Course and Prognosis of Hospitalized Patients With Cirrhosis

Liver Cirrhosis

The aim of this prospective study is to evaluate the natural course and prognosis of hospitalized patients with liver cirrhosis.

Recruiting4 enrollment criteria
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