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Active clinical trials for "Liver Cirrhosis"

Results 321-330 of 1394

Safety and Efficacy of Simtuzumab (SIM, GS-6624) in Adults With Advanced Liver Fibrosis But Not...

Liver Fibrosis Due to NASH

The primary objective of this study is to evaluate whether SIM (formerly referred to as GS-6624) is effective at preventing the histologic progression of liver fibrosis and the clinical progression to cirrhosis in participants with NASH. It will consist of 2 phases: Randomized Double-Blind Phase Open-Label Phase (optional)

Terminated28 enrollment criteria

Simtuzumab (SIM, GS-6624) in the Treatment of Cirrhosis Due to NASH

Liver Fibrosis Due to NASH

The primary objective of this study is to evaluate the safety and efficacy of SIM (formerly referred to as GS-6624) in adults with compensated cirrhosis due to Non-Alcoholic Steatohepatitis (NASH). It will consist of 2 phases: Randomized Double-Blind Phase Open-Label Phase (optional)

Terminated29 enrollment criteria

Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency

Alpha-1-antitrypsin DeficiencyLiver Cirrhosis

The primary objective is to determine if the medication Carbamazepine, can be used as a therapy for patients with severe liver disease due to Alpha-1-Antitrypsin Deficiency .

Terminated5 enrollment criteria

Preoperative Portal and Splanchnic Flow Measurement Using MRI

Liver Cirrhoses

This study aims to assess the alteration of portal and splanchnic flow using MRI after liver transplantation in patients with splenomegaly or splenic varix.

Active4 enrollment criteria

Early Cycle Ergometry for Critically-Ill Liver Failure Patients in a Transplant Intensive Care Unit...

Liver CirrhosesLiver Failure1 more

Critically-ill patients with liver disease are at high risk of developing sarcopenia and intensive care unit (ICU)-acquired weakness, which are associated with mortality and other poor outcomes. Early physical rehabilitation has shown benefit in ICU settings, but has not been studied in ICU patients with acute and chronic liver failure. Cycle ergometry, or stationary cycling in passive and active modes, may be especially beneficial to such patients due to their high prevalence of severe physical deconditioning and variable mentation. The aim of this study is to examine the feasibility, safety, and benefit of cycle ergometry over standard physical and occupational therapy (PT/OT) in critically-ill patients who have acute or chronic liver disease.

Terminated7 enrollment criteria

Liver Fibrosis in Zambian HIV-HBV Co-infected Patients

Human Immunodeficiency VirusHBV7 more

In this study the investigators will determine risk factors for liver fibrosis among HIV-HBV co-infected patients in Lusaka, Zambia, and assess the long-term effectiveness of antiretroviral drugs in the prevention and/or reduction of liver disease.

Active6 enrollment criteria

Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary...

Liver CirrhosisBiliary

Primary Biliary Cholangitis (PBC) is a serious, life-threatening, bile acid related liver disease of unknown cause. Without treatment, it frequently progresses to liver fibrosis and eventual cirrhosis requiring liver transplantation or resulting in death. The investigational drug, Obeticholic Acid (OCA) is a modified bile acid and FXR agonist that is derived from the primary human bile acid chenodeoxycholic acid. The key mechanisms of action of OCA, including its choleretic, anti-inflammatory, and anti-fibrotic properties, underlie its hepatoprotective effects and result in attenuation of injury and improved liver function in a cholestatic liver disease such as PBC. The study will assess the effect of OCA compared to placebo, combined with stable standard care, on clinical outcomes in PBC participants.

Terminated37 enrollment criteria

To Evaluate the Safety and Efficacy of Sofosbuvir and Ribavirin in Patients With HCV (Genotype 3)...

HCV Related Cirrhosis

In this prospective randomized trial, A Minimum of 300 consecutive patients of decompensated HCV (Hepatitis C Virus) related cirrhosis, presenting to the Institute of Liver and Biliary Sciences hospital will be included and those patients meeting the entry criteria received treatment with 400 mg of Sofosbuvir, administered orally once daily, and Ribavirin administered orally twice daily, with doses determined according to body weight(600 mg daily in patients with a body weight of ≤60 kg,800 mg daily in patients weighing >60 and ≤80 kg, and1000 mg daily in patients with a body weight of >80 kg). Based on the treatment duration, patients would be randomized in either of the 3 treatment groups - Group 1 - Sofosbuvir + Ribavirin x 24 weeks Group 2 - Sofosbuvir + Ribavirin x 36 weeks Group 3 - Sofosbuvir + Ribavirin x 48 weeks

Terminated15 enrollment criteria

Treatment of Sodium Retention in Liver Cirrhosis With Dexamethasone

Liver Cirrhosis

Accumulation of salt and water in patients with liver disease (so called liver cirrhosis) is possibly related to the increased effect of steroid hormones on salt reabsorption in the kidney. By reducing overall steroid production with the dexamethasone the accumulation of salt and water could be prevented.

Terminated14 enrollment criteria

Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular Carcinoma...

Hepatocellular CarcinomaLiver Cirrhosis

The purpose of this study is to assess the safety of transarterial radioembolization prior to surgical resection or radiofrequency in cirrhotic patients with hepatocellular carcinoma

Terminated19 enrollment criteria
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