search

Active clinical trials for "Chemical and Drug Induced Liver Injury"

Results 41-50 of 59

Immune Responses in Hepatocellular Carcinoma Patients After Treatment With Direct Acting Antiviral...

Drug-Induced Liver Injury

Case control Study to assess the difference of immune cell responses between patients with chronic HCV- related liver cirrhosis who develop HCC after treatment with DAAs and those who do not develop HCC

Completed5 enrollment criteria

A Retrospective Study on Drug Induced Liver Injury in China

Drug-Induced Liver Injury

This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences among all the hospitalized patient, among patients in department of hepatic diseases, digestive diseases, oncology, hematology etc., individually; 2) epidemiologic characteristics of drug-induced liver injury, including suspected medications, clinical types, histological characteristics, severity and outcomes.

Completed5 enrollment criteria

Discrimination of DILI and AIH by Artificial Intelligence

Drug-induced Liver InjuryAutoimmune Hepatitis

A retrospective, multi-center, non-interventional cohort study has been going to explore whether artificial intelligence can discriminate Drug-induced liver injury and Autoimmune hepatitis. A machine learning-based tool will be developed and validated to help clinicians to differentiate between Drug-induced liver injury and Autoimmune hepatitis

Completed31 enrollment criteria

Clarify of Predictive Risk Factors of Chemotherapy-induced Liver Injury

Liver InjuryDrug-Induced

The most common toxicity of TP (docetaxel and cisplatin) chemotherapy is chemotherapy-induced liver injury. However, patients don't always experience same chemotherapy-induced liver injury for the same drugs. Therefore, the investigators designed the present study to clarify risk factors associated with the development of severe hepatotoxicity after therapy with docetaxel and cisplatin for nasopharyngeal carcinoma (NPC).

Unknown status8 enrollment criteria

Assessing Antibiotic Induced Liver Injury for Stratification of Tuberculosis Patients

Drug-Induced Liver InjuryAnti-Tuberculous Drug Reaction1 more

A panel of highly sensitive circulating biomarkers for acute liver injury have been identified and demonstrated to identify liver injury on first presentation to hospital before standard tests are elevated in patients with paracetamol overdose. The investigators wish to test these biomarkers in patients with active and latent tuberculosis to see if they can be used to stratify patients undertaking anti-tuberculosis drug therapy. Anti-tuberculosis drug induced liver injury is the most frequent side-effect of anti-tuberculosis therapy, affecting 2-5% of tuberculosis patients seen at the Royal Infirmary Edinburgh and hindering their effective treatment. Patients will be recruited from the TB out-patient clinic at the Royal Infirmary Edinburgh. Blood samples will be taken every time the patient visits the clinic and also retrieved from the biochemistry lab. The biomarkers in the blood samples will be analysed to determine if they rise in patients who develop liver injury.

Unknown status5 enrollment criteria

Hepatotoxicity of Antituberculosis Therapy (HAT) Study

Chemical and Drug Induced Liver Injury

Drug-induced liver injury (DILI) is a common side effect in antituberculosis therapy, which interuputs the treatment of TB and leads to a higher proportion of Multidrug-Resistence TB(MDR-TB).The study primalily aims to observe the proportion of DILI in antituberculosis therapy. Furthermore, the secondary objective is to study the proportion of liver injury of based liver disase,liver failure and adjustment of chemotherapy in the obersevational study.

Unknown status3 enrollment criteria

A Diagnostic Study on Patients With Drug-induced Liver Injury

Acute Drug-induced Liver InjuryChronic Liver Disease

This study is a multi-center, prospective, non-interventional cohort study with an estimated enrollment of 600 patients with acute DILI. According to the inclusion and exclusion criteria, the RUCAM scale and/or expert evaluation, patients with a clinical diagnosis of acute DILI will be included in the study to establish a multi-center, prospective DILI cohort. Depending on the presence or absence of associated chronic liver disease, the patients will be divided into the basic DILI group with chronic liver disease and basic DILI group without chronic liver disease. All enrolled patients should complete at least six months of follow-up.

Unknown status10 enrollment criteria

A Prospective Cohort Study on Drug-induced Liver Injury in China(DILI-P)

Drug-induced Liver Injury

This is a multi-center, prospective, non-interventional cohort study . Its primary objectives are: assess DILI patients' clinical characteristics, disease progression and influencing factors in clinical practice; learn about suspected drug caused DILI,rechallenging, liver biochemical abnormalities mode, etc.

Unknown status4 enrollment criteria

Surveillance for Early Liver Injuries Caused by Xianlin Gubao Granule

Drug-Induced Liver Injury

This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Granule (XLGB Granule) through a non-intervention observational way. And attempt to establish a predictive model to screen susceptibilities to XLGB Granule.

Unknown status11 enrollment criteria

Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects...

Drug-Induced Liver InjuryLiver Failure

The objectives are to: validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries investigate the physiological range of the circulating miRNA panel in Healthy Subjects and under stress investigate the dysregulation of circulating miRNA panel and their prognostic and predictive values in clinical outcomes in identifying patients at high risk for mortality and acute liver failure. This trial involves peripheral blood sampling from subjects at their earliest presentation and remaining stays in the hospitalization in the emergency department. The investigators will develop panels of miRNAs that are specific indicator of early onset of major organ failures, and correlate clinical outcomes with these miRNAs.

Unknown status4 enrollment criteria
1...456

Need Help? Contact our team!


We'll reach out to this number within 24 hrs