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Active clinical trials for "Digestive System Diseases"

Results 191-200 of 521

Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic...

Pancreatic InsufficiencyCystic Fibrosis3 more

The purpose of this Randomized, Double-blind, Multicenter, Two-period Crossover Study is to Assess the Efficacy and Tolerability of Burlulipase (NM-BL) in Patients with Exocrine Pancreatic Insufficiency due to Cystic Fibrosis

Completed12 enrollment criteria

A Phase I Study to Evaluate the Oral Absorption of Nepadutant in Infants

Infantile ColicInfantile Functional Gastrointestinal Disorders

The purpose of the study is to evaluate the gastrointestinal absorption of nepadutant after single dose as oral solution (and the effect of age on its oral absorption) in infants. Oral absorption is evaluated through the drug recovery in urine.

Completed12 enrollment criteria

A Study of Crofelemer to Treat Diarrhea Irritable Bowel Syndrome

Irritable Bowel SyndromeColonic Diseases2 more

This study is designed to evaluate the safety and effectiveness of an investigational drug, TRN-002 (crofelemer) to relieve the symptoms of diarrhea-predominant irritable bowel syndrome (IBS).

Completed7 enrollment criteria

The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes...

Cytomegalovirus RetinitisHIV Infections1 more

To evaluate the safety and efficacy of oral ganciclovir for prophylaxis against cytomegalovirus (CMV) retinal and gastrointestinal mucosal disease in HIV-infected patients with severe immunosuppression. The most recent treatments against CMV disease have been ganciclovir and foscarnet. Until recently, both drugs required intravenous administration. An oral form of ganciclovir, if shown to be effective therapy against CMV, would be a more suitable method of administration for prophylaxis.

Completed46 enrollment criteria

An Observational Study of Patients With Chronic Gastrointestinal Disease

Gastrointestinal Diseases

TARGET-GASTRO is an observational research study to conduct a comprehensive review of outcomes for patients with the chronic gastrointestinal (GI) diseases: eosinophilic gastrointestinal disease (EGID), ulcerative colitis (UC) or Crohn's disease (CD).

Not yet recruiting12 enrollment criteria

Bee Honey and Functional Dyspepsia in Children

Functional Gastrointestinal Disorders

Functional dyspepsia is a constellation of diverse gastrointestinal disturbing symptoms with multifactorial feature, varying from upper abdominal bloating to nausea and vomiting, that are not attributable to organic causes after proper medical assessment. Treatment options are unsatisfactory due to the lack of identifiable pathophysiology as well as the pharmacological therapy are less effective, so using an additional reliable non-pharmacological therapy would be promising. Bee honey has not only being used as food but also it has being used as an alternative medicine for its several benefits in different health aspects. This study will address the use of bee honey as an adjuvant therapy to functional dyspepsia in children under proper follow-up periods.

Completed12 enrollment criteria

Essentiale® Paste in Patients With Gastrointestinal Symptoms in Acute or Chronic Liver Diseases...

Hepatic and Hepatobiliary Disorders

Primary Objective: To assess safety of Phosphatidylcholine paste 600 mg (ESSENTIALE® paste) oral 3 times a day for 12 weeks in patients with gastrointestinal symptoms in acute and chronic liver diseases. Secondary Objectives: To assess effectiveness on symptomatic improvement in patients with gastrointestinal symptoms in acute and chronic liver diseases. To monitor compliance.

Completed47 enrollment criteria

Efficacy and Tolerability of Buscopan Plus in Painful Gastric or Intestinal Spasms

Gastrointestinal Diseases

Study to evaluate efficacy and tolerability of Buscopan® plus versus Buscopan®, paracetamol, and placebo in patients with painful gastric or intestinal spasms.

Completed35 enrollment criteria

Internet-delivered CBT for Children With Functional Gastrointestinal Disorders - an Open Pilot Study...

Functional Gastrointestinal Disorders

This pilot-study aims to evaluate the effect size and feasibility of internet-delivered cognitive behavior therapy (ICBT) for children (age 8-12 years) with pain-predominant functional gastrointestinal disorders (e.g. irritable bowel syndrome, functional abdominal pain and functional dyspepsia according to the Rome III criteria). The main component investigated in this study is exposure for gastrointestinal symptoms and for feared stimuli and situations. Children will participate along with one of their parents in the treatment. The parents will also receive specific modules with information on how to support their child in the treatment.

Completed5 enrollment criteria

A Double-blinded,Double-dummy Clinical Trial of Chinese Herbal Medicine (MaZiRenWan) for Functional...

Functional ConstipationGastrointestinal Disorders

The objective of this study is to evaluate the efficacy and safety of a Chinese herbal proprietary medicine, MaZiRenWan (MZRW), by comparing with stimulant laxative western medicine (WM), senna, and placebo for patients with functional constipation (FC) in excessive TCM syndrome.

Completed14 enrollment criteria
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